World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
46
Citations
9767
World Ranking
2800
National Ranking
1344

Overview

Kai Tan is affiliated with the Children's Hospital of Philadelphia in the United States. Their research contributions span multiple areas within medicine, with a strong focus on molecular biology, immunology, oncology, hematology, and genetics. These fields are reflected in their extensive publication record and multi-disciplinary approach to biomedical research.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their subfields of study emphasize:

  • Molecular Biology
  • Immunology
  • Oncology
  • Hematology
  • Genetics

The core topics addressed in their work feature:

  • Single-cell and spatial transcriptomics
  • Acute Myeloid Leukemia Research
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Acute Lymphoblastic Leukemia research
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics

Kai Tan has contributed to several recent publications of note, including:

  • "Decade-long leukaemia remissions with persistence of CD4+ CAR T cells," 2022, published in Nature
  • "The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution," 2020, published in Cell
  • "Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy," 2021, published in Cancer Discovery
  • "Developmental trajectory of prehematopoietic stem cell formation from endothelium," 2020, published in Blood
  • "Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging," 2024, published in Cell

The venues where Kai Tan most frequently publishes include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature
  • Nature Communications

Collaborations are a significant part of their research, with frequent co-authors including:

  • Changya Chen
  • Yasin Uzun
  • Wenbao Yu
  • Shovik Bandyopadhyay
  • Jason Xu

Best Publications

  • An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

    Timothy Ravasi;Harukazu Suzuki;Carlo Vittorio Cannistraci;Shintaro Katayama

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

    Harukazu Suzuki;Alistair R.R. Forrest;Erik Van Nimwegen;Carsten O. Daub

  • A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution

    Jonathan S. Packer;Qin Zhu;Chau Huynh;Priya Sivaramakrishnan

  • Global view of enhancer-promoter interactome in human cells.

    Bing He;Changya Chen;Li Teng;Kai Tan

  • Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

    Yan Li;Virginie Esain;Li Teng;Jian Xu

  • Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

    Xiongwei Cai;Long Gao;Li Teng;Jingping Ge

  • H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

    Dario Nicetto;Greg Donahue;Tanya Jain;Tao Peng

  • TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4 + T cell fate and interact with Runx3 to silence Cd4 in CD8 + T cells

    Farrah C. Steinke;Shuyang Yu;Xinyuan Zhou;Bing He

  • Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy.

    Gregory M. Chen;Changya Chen;Rajat K. Das;Peng Gao

  • Discover regulatory DNA elements using chromatin signatures and artificial neural network

    Hiram A. Firpi;Duygu Ucar;Kai Tan

  • EnhancerAtlas: a resource for enhancer annotation and analysis in 105 human cell/tissue types

    Tianshun Gao;Bing He;Sheng Liu;Heng Zhu

  • A Comparative Genomics Approach to Prediction of New Members of Regulons

    Kai Tan;Gabriel Moreno-Hagelsieb;Julio Collado-Vides;Gary D. Stormo

  • Developmental trajectory of prehematopoietic stem cell formation from endothelium

    Qin Zhu;Peng Gao;Joanna Tober;Laura Bennett

  • 4DGenome: a comprehensive database of chromatin interactions.

    Li Teng;Bing He;Jiahui Wang;Kai Tan

  • CytoTalk: De novo construction of signal transduction networks using single-cell transcriptomic data

    Yuxuan Hu;Tao Peng;Lin Gao;Kai Tan;Kai Tan

  • A microfluidic device for epigenomic profiling using 100 cells

    Zhenning Cao;Changya Chen;Bing He;Kai Tan

  • Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.

    Deshun Lu;K. Futterer;S. Korolev;Xinglong Zheng

  • SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data

    Tao Peng;Qin Zhu;Penghang Yin;Kai Tan

  • An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man (vol 140, pg 744, 2010)

    Timothy Ravasi;Harukazu Suzuki;Carlo Vittorio Cannistraci;Shintaro Katayama

Frequent Co-Authors

Nancy A. Speck
Nancy A. Speck University of Pennsylvania
David M. Barrett
David M. Barrett Children's Hospital of Philadelphia
Jesper Tegnér
Jesper Tegnér King Abdullah University of Science and Technology
Timothy Ravasi
Timothy Ravasi Okinawa Institute of Science and Technology
Winston Hide
Winston Hide Harvard Medical School
Sarah A. Teichmann
Sarah A. Teichmann University of Cambridge
Trey Ideker
Trey Ideker University of California, San Diego
Oliver Hofmann
Oliver Hofmann University of Melbourne
Julian Gough
Julian Gough University of Bristol
Sean M. Grimmond
Sean M. Grimmond University of Melbourne

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