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Akira Yamaguchi

Akira Yamaguchi

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
32706
World Ranking
3806
National Ranking
245

Overview

Akira Yamaguchi is affiliated with Tokyo Dental College in Japan. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to related subfields such as Molecular Biology, Rheumatology, Immunology, Genetics, and Endocrinology, Diabetes and Metabolism.

Their work encompasses a range of topics related to bone biology and oral health. These include:

  • Alkaline Phosphatase Research Studies
  • Heterotopic Ossification and Related Conditions
  • Bone and Joint Diseases
  • Bone Metabolism and Diseases
  • Fibroblast Growth Factor Research
  • Bone health and treatments
  • Oral microbiology and periodontitis research

Yamaguchi has published several research papers in peer-reviewed scientific journals. Notable publications include:

  • "Tissue-nonspecific alkaline phosphatase promotes the osteogenic differentiation of osteoprogenitor cells," 2020, Biochemical and Biophysical Research Communications
  • "The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis," 2024, International Journal of Oral Science
  • "Hedgehog Activation Regulates Human Osteoblastogenesis," 2020, Stem Cell Reports
  • "High-Level Expression of Alkaline Phosphatase by Adeno-Associated Virus Vector Ameliorates Pathological Bone Structure in a Hypophosphatasia Mouse Model," 2020, Calcified Tissue International
  • "Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture," 2022, Bone Reports

Frequently publishing in journals such as Biochemical and Biophysical Research Communications, International Journal of Oral Science, Stem Cell Reports, Calcified Tissue International, and Bone Reports, Yamaguchi contributes consistently to scientific discourse on bone-related diseases and cellular mechanisms.

Collaborative research is a characteristic aspect of Yamaguchi's career. Common co-authors include Takashi Nakamura, Toshifumi Azuma, Satoru Matsunaga, Shinichi Abe, and Shoko Onodera, with multiple joint publications highlighting sustained partnerships within their research community.

Best Publications

  • Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

    T Komori;H Yagi;S Nomura;A Yamaguchi

  • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

    Kojiro Sato;Ayako Suematsu;Kazuo Okamoto;Akira Yamaguchi

  • Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.

    T Katagiri;A Yamaguchi;M Komaki;E Abe

  • IL-6 is produced by osteoblasts and induces bone resorption.

    Y Ishimi;C Miyaura;C H Jin;T Akatsu

  • OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

    N Takahashi;T Akatsu;N Udagawa;T Sasaki

  • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1.

    Akira Yamaguchi;Toshihisa Komori;Tatsuo Suda

  • Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

    A Yamaguchi;T Katagiri;T Ikeda;J M Wozney

  • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

    Shigeru Kotake;Kazuto Sato;Kang Jung Kim;Naoyuki Takahashi

  • The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2.

    Takenobu Katagiri;Akira Yamaguchi;Tohru Ikeda;Shusaku Yoshiki

  • Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures.

    Wenguang Liu;Satoru Toyosawa;Tatsuya Furuichi;Naoko Kanatani

  • BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation

    Takuma Matsubara;Kumiko Kida;Akira Yamaguchi;Kenji Hata

  • Cbfa1 isoforms exert functional differences in osteoblast differentiation.

    Hideyuki Harada;Shuzo Tagashira;Masanori Fujiwara;Shinji Ogawa

  • The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells.

    Nobuyuki Udagawa;Naoyuki Takahashi;Takuhiko Akatsu;Takahisa Sasaki

  • Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

    Hideki Nishitoh;Hidenori Ichijo;Michio Kimura;Tomoaki Matsumoto

  • Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6.

    Akira Yamaguchi;Toshinori Ishizuya;Naoki Kintou;Naoki Kintou;Yasuhiro Wada

  • Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells.

    Toshinori Ishizuya;Satoshi Yokose;Masayuki Hori;Toshiharu Noda

  • Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.

    Kojiro Sato;Ayako Suematsu;Tomoki Nakashima;Sayaka Takemoto-Kimura

  • Induction of Osteogenic Differentiation by Hedgehog Proteins

    Takashi Nakamura;Tomonao Aikawa;Motomi Iwamoto-Enomoto;Masahiro Iwamoto

  • Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow

    S. Nishida;A. Yamaguchi;T. Tanizawa;N. Endo

  • Role of prostaglandins in interleukin‐1‐induced bone resorption in mice in vitro

    Takuhiko Akatsu;Naoyuki Takahashi;Nobuyuki Udagawa;Kazunobu Imamura

Frequent Co-Authors

Tatsuo Suda
Tatsuo Suda Saitama Medical University
Toshihisa Komori
Toshihisa Komori Nagasaki University
Naoyuki Takahashi
Naoyuki Takahashi Matsumoto Dental University
Yoshio Miki
Yoshio Miki Tokyo Medical and Dental University
Shigehisa Hirose
Shigehisa Hirose Tokyo Institute of Technology
Takehiko Koji
Takehiko Koji Nagasaki University
Toshiyuki Yoneda
Toshiyuki Yoneda Osaka University
Riko Nishimura
Riko Nishimura Osaka University
Vicki Rosen
Vicki Rosen Harvard University
Nobuyuki Udagawa
Nobuyuki Udagawa Matsumoto Dental University

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