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Biology and Biochemistry

D-Index
53
Citations
10747
World Ranking
16111
National Ranking
1150

Overview

Kunikazu Tsuji is affiliated with Tokyo Medical and Dental University in Japan. Their research primarily focuses on Medicine, with significant contributions to several subfields including Surgery, Rheumatology, Genetics, Urology, and Molecular Biology.

Their scientific work covers a range of topics related to orthopaedics and regenerative medicine. The main areas of study include:

  • Osteoarthritis Treatment and Mechanisms
  • Knee injuries and reconstruction techniques
  • Mesenchymal stem cell research
  • Periodontal Regeneration and Treatments
  • Total Knee Arthroplasty Outcomes
  • Tendon Structure and Treatment
  • Orthopaedic implants and arthroplasty

Tsuji has frequently published in journals such as:

  • Journal of Orthopaedic Research®
  • Osteoarthritis and Cartilage
  • Biochemical and Biophysical Research Communications
  • Scientific Reports
  • Research Square

Among their recent papers are:

  • Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model, 2020, The American Journal of Sports Medicine
  • Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain, 2020, Journal of Orthopaedic Research®
  • Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci, 2021, Stem Cell Research & Therapy
  • Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model, 2020, Osteoarthritis and Cartilage
  • Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF, 2020, Stem Cell Reviews and Reports

Tsuji collaborates frequently with several researchers including Hideyuki Koga, Ichiro Sekiya, Kazumasa Miyatake, Yusuke Nakagawa, and Hiroki Katagiri. These collaborations have produced numerous publications in their field.

Best Publications

  • BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

    Kunikazu Tsuji;Amitabha Bandyopadhyay;Brian D Harfe;Karen Cox

  • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis.

    Amitabha Bandyopadhyay;Kunikazu Tsuji;Karen Ann Cox;Brian D Harfe

  • SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.

    Ichiro Sekiya;Kunikazu Tsuji;Peter Koopman;Hideto Watanabe

  • Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property

    R Salingcarnboriboon;H Yoshitake;K Tsuji;M Obinata

  • Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin.

    Muneaki Ishijima;Susan R. Rittling;Teruhito Yamashita;Kunikazu Tsuji

  • Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

    Kenji Yumoto;Muneaki Ishijima;Susan R. Rittling;Kunikazu Tsuji

  • Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone.

    Yoshinori Asou;Susan R. Rittling;Hiroyuki Yoshitake;Kunikazu Tsuji

  • Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis

    Ichiro Sekiya;Miyoko Ojima;Shiro Suzuki;Mika Yamaga

  • Osteopontin Expression in Osteoblasts and Osteocytes During Bone Formation Under Mechanical Stress in the Calvarial Suture In Vivo

    Mikihiko Morinobu;Muneaki Ishijima;Susan R Rittling;Kunikazu Tsuji

  • Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model.

    D. Hatsushika;T. Muneta;T. Nakamura;M. Horie

  • Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats.

    N. Ozeki;T. Muneta;H. Koga;Y. Nakagawa

  • Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits.

    Takashi Miyamoto;Takeshi Muneta;Takashi Tabuchi;Kenji Matsumoto

  • Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin.

    Hideyo Ihara;David T. Denhardt;Koichi Furuya;Teruhito Yamashita

  • Expression of the PEBP2αA/AML3/CBFA1 Gene is Regulated by BMP4/7 Heterodimer and Its Overexpression Suppresses Type I Collagen and Osteocalcin Gene Expression in Osteoblastic and Nonosteoblastic Mesenchymal Cells

    K Tsuji;Y Ito;M Noda

  • Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells.

    Kunikazu Tsuji;Miyoko Ojima;Koji Otabe;Masafumi Horie

  • Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs

    Yusuke Nakagawa;Takeshi Muneta;S. Kondo;Mitsuru Mizuno

  • Mesenchymal Stem Cells in Synovial Fluid Increase After Meniscus Injury

    Yu Matsukura;Takeshi Muneta;Kunikazu Tsuji;Hideyuki Koga

  • Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs

    Tomomasa Nakamura;Ichiro Sekiya;Takeshi Muneta;Daisuke Hatsushika

  • Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems

    M. Udo;T. Muneta;K. Tsuji;N. Ozeki

  • Osteopontin Deficiency Reduces Experimental Tumor Cell Metastasis to Bone and Soft Tissues

    Hiroyuki Nemoto;Susan R. Rittling;Hiroyuki Yoshitake;Koichi Furuya

Frequent Co-Authors

Ichiro Sekiya
Ichiro Sekiya Tokyo Medical and Dental University
Takeshi Muneta
Takeshi Muneta Tokyo Medical and Dental University
Masaki Noda
Masaki Noda Tokyo Medical and Dental University
Susan R. Rittling
Susan R. Rittling Harvard University
David T. Denhardt
David T. Denhardt Rutgers, The State University of New Jersey
Vicki Rosen
Vicki Rosen Harvard University
Toshihisa Komori
Toshihisa Komori Nagasaki University
Aris N. Economides
Aris N. Economides Regeneron (United States)
Eiji Kobayashi
Eiji Kobayashi Keio University
Peter Koopman
Peter Koopman University of Queensland

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