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Toshimitsu Uede

Toshimitsu Uede

D-Index & Metrics

Microbiology

D-Index
55
Citations
13213
World Ranking
3790
National Ranking
152

Overview

Toshimitsu Uede is affiliated with Hokkaido University in Japan and focuses research efforts primarily in the domains of medicine and biochemistry, genetics, and molecular biology. The work encompasses several interrelated subfields, including rheumatology, genetics, molecular biology, and physiology.

The core scientific inquiry revolves around bone and dental protein studies, digestive system and related health, bone metabolism and diseases, and diet and metabolism studies. The concentration on these topics reflects a multidisciplinary approach to understanding metabolic disorders and their physiological underpinnings.

Recent scholarly output includes publications in recognized scientific journals. These are:

  • Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice, 2020, Journal of Cell Communication and Signaling
  • Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent Manner, 2022, mBio

Frequently collaborating co-authors include Machiko Honda, Chiemi Kimura, Shigeyuki Kon, Jianing Chen, and Ping Zeng. These co-authorships indicate active participation in collaborative research projects focused on the key scientific themes.

Scientific contributions have been disseminated mainly through journals such as the Journal of Cell Communication and Signaling and mBio, with each venue featuring multiple publications. This reflects a consistent research output over time within specialized academic forums.

Best Publications

  • Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

    Takeshi Takahashi;Tomoyuki Tagami;Sayuri Yamazaki;Toshimitsu Uede

  • Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

    Shigeki Chiba;Muhammad Baghdadi;Hisaya Akiba;Hironori Yoshiyama

  • CD44 Variants but not CD44s Cooperate with β1-containing Integrins to Permit Cells to Bind to Osteopontin Independently of Arginine-glycine-aspartic Acid, thereby Stimulating Cell Motility and Chemotaxis

    Yohko U. Katagiri;Jonathan Sleeman;Hideki Fujii;Peter Herrlich

  • Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

    Kenji Yumoto;Muneaki Ishijima;Susan R. Rittling;Kunikazu Tsuji

  • TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor

    Ju-Qiang Wang;Junko Kon;Chihiro Mogi;Masayuki Tobo

  • Osteopontin as a Mediator of NKT Cell Function in T Cell-Mediated Liver Diseases

    Hongyan Diao;Shigeyuki Kon;Kazuya Iwabuchi;Chiemi Kimura

  • Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritis.

    Nobuchika Yamamoto;Fumihiko Sakai;Shigeyuki Kon;Junko Morimoto

  • Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype.

    Andreas C. Renkl;Julia Wussler;Thomas Ahrens;Käthe Thoma

  • Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice

    Keiko Danzaki;Yutaka Matsui;Masahiro Ikesue;Daichi Ohta

  • Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases

    Toshimitsu Uede

  • Role of osteopontin in the pathogenesis of bleomycin-induced pulmonary fibrosis

    Fumiyuki Takahashi;Kazuhisa Takahashi;Tatsuma Okazaki;Kayo Maeda

  • Expression of osteopontin in Kupffer cells and hepatic macrophages and Stellate cells in rat liver after carbon tetrachloride intoxication: a possible factor for macrophage migration into hepatic necrotic areas.

    Rumiko Kawashima;Satoshi Mochida;Atsushi Matsui;YuSuFu YouLuTuZ

  • Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.

    Ayako Nakamura-Ishizu;Yuji Okuno;Yoshiki Omatsu;Keisuke Okabe

  • Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer.

    Alison L. Allan;Rosamma George;Rosamma George;Sharon A. Vantyghem;Mark W. Lee;Mark W. Lee

  • Enhanced local production of osteopontin in rheumatoid joints

    Shiro Ohshima;Norihiko Yamaguchi;Katsuhiro Nishioka;Toru Mima

  • Enhanced Expression of Osteopontin in Human Diabetic Artery and Analysis of Its Functional Role in Accelerated Atherogenesis

    Minoru Takemoto;Koutaro Yokote;Motonobu Nishimura;Takashi Shigematsu

  • High Plasma Osteopontin Level and Its Relationship with Interleukin-12–mediated Type 1 T Helper Cell Response in Tuberculosis

    Yoshinobu Koguchi;Kazuyoshi Kawakami;Kaori Uezu;Kiyoyasu Fukushima

  • Vascular endothelial growth factor and osteopontin in tumor biology.

    N Shijubo;T Uede;S Kon;M Nagata

  • Functions and development of red pulp macrophages.

    Daisuke Kurotaki;Toshimitsu Uede;Tomohiko Tamura

  • Osteopontin is produced by mast cells and affects IgE‐mediated degranulation and migration of mast cells

    Akiko Nagasaka;Hiroyuki Matsue;Hiroyuki Matsue;Hironori Matsushima;Rui Aoki

  • Osteopontin, a coordinator of host defense system : A cytokine or an extracellular adhesive protein?

    Toshimitsu Uede;Yohko Katagiri;Junko Iizuka;Masaaki Murakami

  • Induction of immunologic tolerance to cardiac allograft by simultaneous blockade of inducible co-stimulator and cytotoxic T-lymphocyte antigen 4 pathway.

    Hisanori Kosuge;Jun-Ichi Suzuki;Ryo Gotoh;Noritaka Koga

  • Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes

    Hiroshi Ueno;Masaaki Murakami;Masahiro Okumura;Tsuyoshi Kadosawa

  • Development of autoimmune insulitis is prevented in Eαd but not in Aβk NOD transgenic mice

    Masahiro Uehira;Masashi Uno;Thomas Kürner;Hitoshi Kikutani

  • Antibodies to different peptides in osteopontin reveal complexities in the various secreted forms

    Shigeyuki Kon;Masahiro Maeda;Tatsuya Segawa;Yoshiaki Hagiwara

  • α9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis

    Masashi Kanayama;Daisuke Kurotaki;Junko Morimoto;Tsuyoshi Asano

  • Transcriptional repression and differential splicing of Fas mRNA by early transposon (ETn) insertion in autoimmune lpr mice.

    S. Kobayashi;T. Hirano;M. Kakinuma;T. Uede

  • A CD153+CD4+ T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

    Suhail Tahir;Yuji Fukushima;Keiko Sakamoto;Kyosuke Sato

  • Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies.

    Junko Iizuka;Yohko Katagiri;Norihiro Tada;Masaaki Murakami

  • Critical function of T cell death‐associated gene 8 in glucocorticoid‐induced thymocyte apoptosis

    Noriko Tosa;Masaaki Murakami;Wen Yi Jia;Minesuke Yokoyama

Frequent Co-Authors

Masaaki Murakami
Masaaki Murakami Hokkaido University
Ann F. Chambers
Ann F. Chambers University of Western Ontario
David T. Denhardt
David T. Denhardt Rutgers, The State University of New Jersey
Masahiro Maeda
Masahiro Maeda Osaka University
Susan R. Rittling
Susan R. Rittling Harvard University
Mitsuaki Isobe
Mitsuaki Isobe Tokyo Medical and Dental University
Satoru Todo
Satoru Todo Hokkaido University
Ikuo Saiki
Ikuo Saiki University of Toyama
Shigeaki Ohno
Shigeaki Ohno Hokkaido University
Lanjuan Li
Lanjuan Li Zhejiang University

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