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Fumikazu Okajima

Fumikazu Okajima

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
14295
World Ranking
6799
National Ranking
455

Overview

Fumikazu Okajima is affiliated with Aomori University in Japan and has contributed significantly to research primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans several specialized subfields including Molecular Biology, Physiology, Rheumatology, Immunology and Allergy, and Endocrinology, Diabetes and Metabolism.

The scientist's research covers a diverse array of topics, with a focus on mechanisms underlying neuroinflammation and neurodegeneration, sphingolipid metabolism and signaling, nitric oxide and endothelin effects, bone and dental protein studies, cell adhesion molecules, metabolism related to diabetes and cancer, and the regulation of growth hormone and insulin-like growth factors.

Fumikazu Okajima has authored several recent papers, detailing findings in various biomedical areas. Notable publications include:

  • The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model, 2020, Scientific Reports
  • A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism, 2020, Biochemical and Biophysical Research Communications
  • Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells, 2020, Journal of Reproduction and Development
  • Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice, 2021, Evidence-based Complementary and Alternative Medicine
  • Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone, 2021, Journal of Inflammation Research

The venues where these works were published include Scientific Reports, Biochemical and Biophysical Research Communications, Journal of Reproduction and Development, Evidence-based Complementary and Alternative Medicine, and Journal of Inflammation Research.

Throughout their career, Okajima has collaborated extensively with several researchers. Frequent coauthors include Kōichi Sato, Chihiro Mogi, Hideaki Tomura, Dong-Soon Im, and Shiori Musha, with several joint publications documented.

Best Publications

  • Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.

    Naoya Murata;Koichi Sato;Junko Kon;Hideaki Tomura

  • Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

    Yosuke M. Morizawa;Yosuke M. Morizawa;Yuri Hirayama;Noubuhiko Ohno;Shinsuke Shibata

  • Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

    Hideo Ohta;Koichi Sato;Naoya Murata;Alatangaole Damirin

  • Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells

    Takao Kimura;Koichi Sato;Atsushi Kuwabara;Hideaki Tomura

  • Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

    F Okajima;T Katada;M Ui

  • Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

    Fumikazu Okajima

  • Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

    Junko Kon;Koichi Sato;Tomoko Watanabe;Hideaki Tomura

  • Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

    H Ohta;F Okajima;M Ui

  • TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor

    Ju-Qiang Wang;Junko Kon;Chihiro Mogi;Masayuki Tobo

  • P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

    F Okajima;Y Tokumitsu;Y Kondo;M Ui

  • Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.

    Takao Kimura;Tomoko Watanabe;Koichi Sato;Junko Kon

  • High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors

    Takao Kimura;Koichi Sato;Enkhzol Malchinkhuu;Hideaki Tomura

  • Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.

    Takao Kimura;Hideaki Tomura;Chihiro Mogi;Atsushi Kuwabara

  • Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors.

    Hideaki Tomura;Chihiro Mogi;Koichi Sato;Fumikazu Okajima

  • Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.

    Koichi Sato;Enkhzol Malchinkhuu;Yuta Horiuchi;Chihiro Mogi

  • Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma.

    Haruka Aoki;Takeshi Hisada;Tamotsu Ishizuka;Mitsuyoshi Utsugi

  • Regulation of inflammation by extracellular acidification and proton-sensing GPCRs.

    Fumikazu Okajima

  • Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1

    Takayuki Yamada;Koichi Sato;Mayumi Komachi;Enkhzol Malchinkhuu

  • Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.

    Yuji Yamazaki;Junko Kon;Koichi Sato;Hideaki Tomura

  • Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.

    Chihiro Mogi;Masayuki Tobo;Hideaki Tomura;Naoya Murata

Frequent Co-Authors

Koichi Sato
Koichi Sato Gunma University
Hideaki Tomura
Hideaki Tomura Meiji University
Hitoshi Kurose
Hitoshi Kurose University of Tokushima
Michio Ui
Michio Ui Tokyo Metropolitan Institute of Medical Science
Masatomo Mori
Masatomo Mori Gunma University
Hae Young Chung
Hae Young Chung Pusan National University
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Masahiko Kurabayashi
Masahiko Kurabayashi Gunma University
Toshiaki Katada
Toshiaki Katada Musashino University
Leonard D. Kohn
Leonard D. Kohn National Institutes of Health

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