D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 61 Citations 10,856 149 World Ranking 5133 National Ranking 352

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Biochemistry

Fumikazu Okajima spends much of his time researching Receptor, Sphingosine, Biochemistry, Cell biology and Sphingosine-1-phosphate. His studies deal with areas such as Extracellular, Molecular biology and Phosphatidylinositol as well as Receptor. Fumikazu Okajima studied Sphingosine and Chinese hamster ovary cell that intersect with Sphingosine-1-phosphate receptor, Radioligand Assay, Chromatography, Immediate early protein and Ligand binding assay.

His Sphingosine-1-phosphate research is multidisciplinary, incorporating elements of Plasma protein binding, Umbilical vein, Lipoprotein and High-density lipoprotein. His Lipoprotein study falls within the topics of Internal medicine and Endocrinology. The Pertussis toxin study combines topics in areas such as Purinergic receptor, Adenosine, Phospholipase C and Inositol.

His most cited work include:

  • Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. (343 citations)
  • Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors (338 citations)
  • Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells (242 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Receptor, Endocrinology, Internal medicine, Cell biology and Biochemistry. His Receptor study frequently draws parallels with other fields, such as Extracellular. His studies deal with areas such as Cell growth and Pertussis toxin as well as Endocrinology.

His study in the field of Signal transduction, Protein kinase A, Protein kinase B and Wortmannin also crosses realms of Mechanism. His work on Sphingolipid is typically connected to Lysophosphatidylcholine as part of general Biochemistry study, connecting several disciplines of science. His research investigates the connection between Sphingosine and topics such as Lipoprotein that intersect with issues in High-density lipoprotein.

He most often published in these fields:

  • Receptor (44.33%)
  • Endocrinology (37.63%)
  • Internal medicine (37.63%)

What were the highlights of his more recent work (between 2012-2020)?

  • Receptor (44.33%)
  • Immunology (10.82%)
  • Cell biology (32.47%)

In recent papers he was focusing on the following fields of study:

Fumikazu Okajima mostly deals with Receptor, Immunology, Cell biology, Biochemistry and Extracellular. His Receptor study is related to the wider topic of Internal medicine. His Cell biology research is multidisciplinary, incorporating perspectives in Sphingosine and Mast cell.

His Sphingosine research focuses on Neurite and how it relates to Lysophosphatidic acid. His Extracellular study which covers Signal transduction that intersects with Mutation. His Apolipoprotein B study in the realm of Endocrinology connects with subjects such as Club cell.

Between 2012 and 2020, his most popular works were:

  • Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway (120 citations)
  • Regulation of inflammation by extracellular acidification and proton-sensing GPCRs. (111 citations)
  • Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. (42 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Cytokine

His main research concerns Receptor, Biochemistry, Immunology, Cell biology and Inflammation. His research in the fields of Antagonist overlaps with other disciplines such as Lead. In the field of Immunology, his study on Chemokine receptor, Immunoglobulin E and C-C chemokine receptor type 7 overlaps with subjects such as Ionotropic effect and Goblet cell.

His study in Cell biology is interdisciplinary in nature, drawing from both Sphingosine and M2 Macrophage. His research in Inflammation intersects with topics in TRPV1, Immune system, Metabotropic receptor, Bronchoconstriction and Acid-sensing ion channel. His Extracellular research is multidisciplinary, incorporating elements of cAMP-dependent pathway, Kinase, Protein kinase A, Forskolin and Cell type.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.

Naoya Murata;Koichi Sato;Junko Kon;Hideaki Tomura.
Biochemical Journal (2000)

527 Citations

Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

Hideo Ohta;Koichi Sato;Naoya Murata;Alatangaole Damirin.
Molecular Pharmacology (2003)

401 Citations

Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells

Takao Kimura;Koichi Sato;Atsushi Kuwabara;Hideaki Tomura.
Journal of Biological Chemistry (2001)

372 Citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

Fumikazu Okajima.
Biochimica et Biophysica Acta (2002)

307 Citations

Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

Junko Kon;Koichi Sato;Tomoko Watanabe;Hideaki Tomura.
Journal of Biological Chemistry (1999)

304 Citations

Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

H Ohta;F Okajima;M Ui.
Journal of Biological Chemistry (1985)

290 Citations

P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

F Okajima;Y Tokumitsu;Y Kondo;M Ui.
Journal of Biological Chemistry (1987)

286 Citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.

Takao Kimura;Tomoko Watanabe;Koichi Sato;Junko Kon.
Biochemical Journal (2000)

272 Citations

High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors

Takao Kimura;Koichi Sato;Enkhzol Malchinkhuu;Hideaki Tomura.
Arteriosclerosis, Thrombosis, and Vascular Biology (2003)

263 Citations

Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.

Takao Kimura;Hideaki Tomura;Chihiro Mogi;Atsushi Kuwabara.
Journal of Biological Chemistry (2006)

244 Citations

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