Fumikazu Okajima spends much of his time researching Receptor, Sphingosine, Biochemistry, Cell biology and Sphingosine-1-phosphate. His studies deal with areas such as Extracellular, Molecular biology and Phosphatidylinositol as well as Receptor. Fumikazu Okajima studied Sphingosine and Chinese hamster ovary cell that intersect with Sphingosine-1-phosphate receptor, Radioligand Assay, Chromatography, Immediate early protein and Ligand binding assay.
His Sphingosine-1-phosphate research is multidisciplinary, incorporating elements of Plasma protein binding, Umbilical vein, Lipoprotein and High-density lipoprotein. His Lipoprotein study falls within the topics of Internal medicine and Endocrinology. The Pertussis toxin study combines topics in areas such as Purinergic receptor, Adenosine, Phospholipase C and Inositol.
His primary areas of study are Receptor, Endocrinology, Internal medicine, Cell biology and Biochemistry. His Receptor study frequently draws parallels with other fields, such as Extracellular. His studies deal with areas such as Cell growth and Pertussis toxin as well as Endocrinology.
His study in the field of Signal transduction, Protein kinase A, Protein kinase B and Wortmannin also crosses realms of Mechanism. His work on Sphingolipid is typically connected to Lysophosphatidylcholine as part of general Biochemistry study, connecting several disciplines of science. His research investigates the connection between Sphingosine and topics such as Lipoprotein that intersect with issues in High-density lipoprotein.
Fumikazu Okajima mostly deals with Receptor, Immunology, Cell biology, Biochemistry and Extracellular. His Receptor study is related to the wider topic of Internal medicine. His Cell biology research is multidisciplinary, incorporating perspectives in Sphingosine and Mast cell.
His Sphingosine research focuses on Neurite and how it relates to Lysophosphatidic acid. His Extracellular study which covers Signal transduction that intersects with Mutation. His Apolipoprotein B study in the realm of Endocrinology connects with subjects such as Club cell.
His main research concerns Receptor, Biochemistry, Immunology, Cell biology and Inflammation. His research in the fields of Antagonist overlaps with other disciplines such as Lead. In the field of Immunology, his study on Chemokine receptor, Immunoglobulin E and C-C chemokine receptor type 7 overlaps with subjects such as Ionotropic effect and Goblet cell.
His study in Cell biology is interdisciplinary in nature, drawing from both Sphingosine and M2 Macrophage. His research in Inflammation intersects with topics in TRPV1, Immune system, Metabotropic receptor, Bronchoconstriction and Acid-sensing ion channel. His Extracellular research is multidisciplinary, incorporating elements of cAMP-dependent pathway, Kinase, Protein kinase A, Forskolin and Cell type.
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Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.
Naoya Murata;Koichi Sato;Junko Kon;Hideaki Tomura.
Biochemical Journal (2000)
Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors
Hideo Ohta;Koichi Sato;Naoya Murata;Alatangaole Damirin.
Molecular Pharmacology (2003)
Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells
Takao Kimura;Koichi Sato;Atsushi Kuwabara;Hideaki Tomura.
Journal of Biological Chemistry (2001)
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
Biochimica et Biophysica Acta (2002)
Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells
Junko Kon;Koichi Sato;Tomoko Watanabe;Hideaki Tomura.
Journal of Biological Chemistry (1999)
Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.
H Ohta;F Okajima;M Ui.
Journal of Biological Chemistry (1985)
P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.
F Okajima;Y Tokumitsu;Y Kondo;M Ui.
Journal of Biological Chemistry (1987)
Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.
Takao Kimura;Tomoko Watanabe;Koichi Sato;Junko Kon.
Biochemical Journal (2000)
High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors
Takao Kimura;Koichi Sato;Enkhzol Malchinkhuu;Hideaki Tomura.
Arteriosclerosis, Thrombosis, and Vascular Biology (2003)
Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.
Takao Kimura;Hideaki Tomura;Chihiro Mogi;Atsushi Kuwabara.
Journal of Biological Chemistry (2006)
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