World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
14094
World Ranking
15437
National Ranking
1092

Research.com Recognitions

  • 1991 - Paul Ehrlich and Ludwig Darmstaedter Prize

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Internal medicine

Michio Ui mainly focuses on Biochemistry, Pertussis toxin, Cyclase, Receptor and GTP'. Michio Ui has researched Pertussis toxin in several fields, including Chemotaxis, Arachidonic acid, Inositol, Phospholipase C and Membrane protein. Michio Ui interconnects Molecular biology, Adenylate kinase and Peptide in the investigation of issues within Cyclase.

His study looks at the intersection of Molecular biology and topics like Adrenergic receptor with Muscarinic acetylcholine receptor. In his study, Sphingosine-1-phosphate receptor, Endocrinology, Internal medicine and Sphingolipid is strongly linked to Transfection, which falls under the umbrella field of Receptor. His GTP' research includes themes of Alpha, Beta and G alpha subunit.

His most cited work include:

  • A new micromethod for the colorimetric determination of inorganic phosphate. (695 citations)
  • COLORIMETRIC DETERMINATION OF FREE FATTY ACIDS IN BIOLOGICAL FLUIDS. (630 citations)
  • An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue (617 citations)

What are the main themes of his work throughout his whole career to date?

Biochemistry, Internal medicine, Endocrinology, Pertussis toxin and Cyclase are his primary areas of study. Michio Ui connects Biochemistry with Biological activity in his research. His Endocrinology research focuses on Serotonin and how it connects with Carbohydrate metabolism.

His Pertussis toxin research is classified as research in Receptor. His study on Receptor is mostly dedicated to connecting different topics, such as Cell biology. His work in Cyclase addresses issues such as Adenylate kinase, which are connected to fields such as Agonist.

He most often published in these fields:

  • Biochemistry (34.62%)
  • Internal medicine (30.77%)
  • Endocrinology (30.77%)

What were the highlights of his more recent work (between 1998-2017)?

  • Cell biology (13.85%)
  • Receptor (18.46%)
  • Sphingosine (6.92%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Cell biology, Receptor, Sphingosine, Sphingosine-1-phosphate and Biochemistry. His Receptor study combines topics from a wide range of disciplines, such as Endocrinology and High-throughput screening. His Sphingosine research incorporates elements of Molecular biology, Signal transduction, Phospholipase C and Inositol phosphate.

His studies in Sphingosine-1-phosphate integrate themes in fields like Phospholipase, Inositol trisphosphate and Intracellular, Second messenger system. His Forskolin research is multidisciplinary, incorporating perspectives in Rolipram, Tyrosine, Adenylate kinase and GTP'. His work on Glycogen phosphorylase, Cerebral cortex, Cyclase and Cyclase activity as part of general Internal medicine study is frequently linked to Desipramine, therefore connecting diverse disciplines of science.

Between 1998 and 2017, his most popular works were:

  • Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. (343 citations)
  • Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells (242 citations)
  • Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. (211 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Internal medicine
  • Biochemistry

His primary scientific interests are in Sphingosine, Cell biology, Signal transduction, Inositol phosphate and Receptor. His Sphingosine research is under the purview of Biochemistry. His Biochemistry study frequently links to related topics such as Pharmacology.

His Signal transduction research integrates issues from Sphingosine-1-phosphate receptor, Angiogenesis and Forskolin. His Inositol phosphate study integrates concerns from other disciplines, such as Sphingolipid, Transfection and Chinese hamster ovary cell. His research on Receptor often connects related areas such as Endocrinology.

Best Publications

  • A new micromethod for the colorimetric determination of inorganic phosphate.

    Koichi Itaya;Michio Ui

  • COLORIMETRIC DETERMINATION OF FREE FATTY ACIDS IN BIOLOGICAL FLUIDS.

    Koichi Itaya;Michio Ui

  • An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

    Miyuki Honma;Tomokazu Satoh;Junichi Takezawa;Michio Ui

  • Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

    Michio Ui

  • Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

    H Kurose;T Katada;T Amano;M Ui

  • Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.

    Naoya Murata;Koichi Sato;Junko Kon;Hideaki Tomura

  • Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

    T Katada;M Oinuma;M Ui

  • Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells

    Takao Kimura;Koichi Sato;Atsushi Kuwabara;Hideaki Tomura

  • Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

    F Okajima;T Katada;M Ui

  • Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis.

    Tomohiro Hirahashi;Misako Matsumoto;Kaoru Hazeki;Yoshiko Saeki

  • A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells.

    M Tamura;K Nogimori;M Yajima;K Ase

  • Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

    Junko Kon;Koichi Sato;Tomoko Watanabe;Hideaki Tomura

  • Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

    T Katada;M Oinuma;M Ui

  • Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

    H Ohta;F Okajima;M Ui

  • Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.

    Takao Kimura;Tomoko Watanabe;Koichi Sato;Junko Kon

  • The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein

    Toshiaki Katada;Makoto Tamura;Michio Ui

  • A role of phosphofructokinase in pH-dependent regulation of glycolysis

    Michio Ui

  • A new GTP-binding protein in brain tissues serving as the specific substrate of islet-activating protein, pertussis toxin

    Toshiaki Katada;Masayuki Oinuma;Kayoko Kusakabe;Michio Ui

  • In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora.

    E Koyama;K Kitazawa;Y Ohori;O Izawa

  • Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells

    T Katada;T Amano;M Ui

Frequent Co-Authors

Fumikazu Okajima
Fumikazu Okajima Aomori University
Koichi Sato
Koichi Sato Gunma University
Hideaki Tomura
Hideaki Tomura Meiji University
Toshiaki Katada
Toshiaki Katada Musashino University
Akira Ito
Akira Ito Nagoya University
Tsukasa Seya
Tsukasa Seya Hokkaido University
Yoshiro Inoue
Yoshiro Inoue Hokkaido University
Misako Matsumoto
Misako Matsumoto Aomori University
Yoshiro Saito
Yoshiro Saito Tohoku University
Hiroshi Itoh
Hiroshi Itoh Yamaguchi University

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