His primary areas of investigation include Cell biology, Molecular biology, Biochemistry, Vascular smooth muscle and Receptor. His studies in Cell biology integrate themes in fields like Cell migration, Cyclin-dependent kinase, Cyclin D1, Cell cycle and Chemotaxis. His studies deal with areas such as Endothelins, Interleukin-21 receptor, Endothelin receptor type A, Peptide sequence and Signal transduction as well as Molecular biology.
In the field of Biochemistry, his study on Sphingosine-1-phosphate, Inositol trisphosphate, Phospholipase C and Inositol overlaps with subjects such as Alkaline phosphatase. The Vascular smooth muscle portion of his research involves studies in Endocrinology and Internal medicine. The various areas that he examines in his Myosin light-chain kinase study include Muscle contraction and Rho-associated protein kinase.
His primary scientific interests are in Cell biology, Internal medicine, Endocrinology, Vascular smooth muscle and Molecular biology. His work deals with themes such as Receptor, Sphingosine-1-phosphate and Cell migration, which intersect with Cell biology. The Sphingosine-1-phosphate study combines topics in areas such as Cancer research, Angiogenesis and Lipid signaling.
His Cell migration study combines topics from a wide range of disciplines, such as Protein kinase B and Chemotaxis. Phospholipase C is closely connected to Protein kinase C in his research, which is encompassed under the umbrella topic of Endocrinology. As a part of the same scientific family, he mostly works in the field of Vascular smooth muscle, focusing on Myosin light-chain kinase and, on occasion, Rho-associated protein kinase, Vascular smooth muscle contraction and Contraction.
Yoh Takuwa mainly focuses on Cell biology, Internal medicine, Endocrinology, Sphingosine-1-phosphate and Sphingosine-1-phosphate receptor. His Cell biology research incorporates themes from Receptor, Lipid signaling and Angiogenesis. He has researched Angiogenesis in several fields, including Biochemistry and Endocytosis.
His Internal medicine research includes themes of Endothelial stem cell and Rho-associated protein kinase. His Endocrinology research incorporates elements of Myosin light-chain kinase and RHOA. His Sphingosine-1-phosphate research is multidisciplinary, relying on both G protein-coupled receptor, Oncology, Function and Predictive biomarker.
His main research concerns Cell biology, Internal medicine, Endocrinology, Angiogenesis and Receptor. His Cell biology research is multidisciplinary, incorporating perspectives in Sphingosine-1-phosphate and Internalization. His study in Sphingosine-1-phosphate is interdisciplinary in nature, drawing from both Cancer research and Immunology.
The concepts of his Internal medicine study are interwoven with issues in Myosin-light-chain phosphatase and Rho-associated protein kinase. His studies in Endocrinology integrate themes in fields like Myosin light-chain kinase, Wortmannin and Phosphoinositide 3-kinase. His study looks at the intersection of Receptor and topics like Downregulation and upregulation with Scavenger receptor and Apolipoprotein E.
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Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor.
Takeshi Sakurai;Masashi Yanagisawa;Yoh Takuwa;Hitoshi Miyazaki.
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.
Takehiko Yokomizo;Takashi Izumi;Kyungho Chang;Yoh Takuwa.
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.
Jingsong Xu;Fei Wang;Alexandra Van Keymeulen;Alexandra Van Keymeulen;Paul Herzmark.
Protein kinase C in the regulation of smooth muscle contraction.
Howard Rasmussen;Yoh Takuwa;Susanna Park.
The FASEB Journal (1987)
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.
A. Inoue;Masashi Yanagisawa;Y. Takuwa;Y. Mitsui.
Journal of Biological Chemistry (1989)
A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts
N. Takuwa;Y. Takuwa;Masashi Yanagisawa;K. Yamashita.
Journal of Biological Chemistry (1989)
Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.
Katsutoshi Goto;Yoshitoshi Kasuya;Norio Matsuki;Yoh Takuwa.
Proceedings of the National Academy of Sciences of the United States of America (1989)
Cloning and functional expression of human cDNA for the ETB endothelin receptor
Aiji Sakamoto;Aiji Sakamoto;Masashi Yanagisawa;Takeshi Sakurai;Yoh Takuwa.
Biochemical and Biophysical Research Communications (1991)
EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition.
Hiroyuki Okamoto;Noriko Takuwa;Koichi Gonda;Hiroshi Okazaki.
Journal of Biological Chemistry (1998)
Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3.
Hiroyuki Okamoto;Noriko Takuwa;Takehiko Yokomizo;Naotoshi Sugimoto.
Molecular and Cellular Biology (2000)
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