Thomas J. Gardella

Overview

Best Publications

• Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

  Sébastien Ferrandon;Timothy N Feinstein;Marian Castro;Bin Wang

  586
  Citations

• A mutant Escherichia coli σ70 subunit of RNA polymerase with altered promoter specificity

  Thomas James Gardella;Henry Moyle;Miriam M. Susskind

  413
  Citations

• Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis

  Thomas Gardella;Peter Medveczky;Takeshi Sairenji;Carel Mulder

  397
  Citations

• Parathyroid hormone and parathyroid hormone-related peptide, and their receptors

  Robert C. Gensure;Thomas J. Gardella;Harald Jüppner

  372
  Citations

• Receptors for PTH and pTHrP: their biological importance and functional properties

  Michael Mannstadt;Harald Jüppner;Thomas J. Gardella

  362
  Citations

• Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.

  Gary Hattersley;Thomas Dean;Braden A. Corbin;Hila Bahar

  308
  Citations

• Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism.

  Andrew Arnold;Susan A. Horst;Thomas J. Gardella;Hisamitsu Baba

  296
  Citations

• Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction.

  Clemens Bergwitz;Thomas J. Gardella;Merrilee R. Flannery;John T. Potts

  253
  Citations

• Retromer terminates the generation of cAMP by internalized PTH receptors

  Timothy N Feinstein;Vanessa L Wehbi;Juan A Ardura;David S Wheeler

  238
  Citations

• Altered Selectivity of Parathyroid Hormone (PTH) and PTH-Related Protein (PTHrP) for Distinct Conformations of the PTH/PTHrP Receptor

  Thomas Dean;Jean-Pierre Vilardaga;John T. Potts;Thomas James Gardella

  233
  Citations

• PTH receptor-1 signalling—mechanistic insights and therapeutic prospects

  Ross W. Cheloha;Samuel H. Gellman;Jean-Pierre Vilardaga;Thomas J. Gardella

  231
  Citations

• Endosomal generation of cAMP in GPCR signaling

  Jean-Pierre Vilardaga;Frederic G Jean-Alphonse;Thomas J Gardella

  220
  Citations

• Structure and dynamics of the active human parathyroid hormone receptor-1.

  L.H. Zhao;S. Ma;I. Sutkeviciute;D.D. Shen

  218
  Citations

• Molecular properties of the PTH/PTHrP receptor.

  Thomas J Gardella;Harald Jüppner

  210
  Citations

• Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

  Makoto Okazaki;Sebastien Ferrandon;Jean-Pierre Vilardaga;Mary L. Bouxsein

  173
  Citations

• The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).

  H Jüppner;E Schipani;F R Bringhurst;I McClure

  166
  Citations

• Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides

  Augen A. Pioszak;Naomi R. Parker;Thomas J. Gardella;H. Eric Xu

  164
  Citations

• Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist

  Thomas J. Gardella;Michael D. Luck;Geoff S. Jensen;Ted B. Usdin

  161
  Citations

• Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands.

  H. Takasu;T. J. Gardella;M. D. Luck;J. T. Potts

  157
  Citations

• International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors

  Thomas J. Gardella;Jean-Pierre Vilardaga

  109
  Citations