Thomas J. Gardella mainly focuses on Receptor, Parathyroid hormone, Parathyroid hormone receptor, Signal transduction and Internal medicine. His Receptor research entails a greater understanding of Biochemistry. His biological study spans a wide range of topics, including Molecular biology and Ligand.
His study looks at the relationship between Signal transduction and fields such as Paracrine signalling, as well as how they intersect with chemical problems. His Internal medicine research incorporates elements of Endocrinology, Amino acid sequence homology, COS cells, Binding site and Binding selectivity. His study in the fields of Calcitonin under the domain of Endocrinology overlaps with other disciplines such as Ligand.
His primary scientific interests are in Parathyroid hormone, Receptor, Endocrinology, Internal medicine and Parathyroid hormone receptor. His work carried out in the field of Parathyroid hormone brings together such families of science as Agonist, Extracellular, Biochemistry and Transmembrane domain. His studies in Receptor integrate themes in fields like Signal transduction, Cell biology and Peptide.
In his study, Plasma protein binding is strongly linked to Stereochemistry, which falls under the umbrella field of Peptide. His study in Endocrinology is interdisciplinary in nature, drawing from both Calcium metabolism and Inverse agonist. His study on Calcitonin, Hypercalciuria, Peptide hormone and Bone resorption is often connected to Osteocyte as part of broader study in Internal medicine.
Receptor, Parathyroid hormone, Internal medicine, Endocrinology and G protein-coupled receptor are his primary areas of study. His work on Ligand as part of general Receptor research is often related to Parathyroid hormone receptor, thus linking different fields of science. Thomas J. Gardella interconnects Calcium metabolism and Hormone in the investigation of issues within Parathyroid hormone.
His work on Inverse agonist, Hypoparathyroidism and Hypercalciuria as part of general Internal medicine study is frequently linked to Context, therefore connecting diverse disciplines of science. His work on Osteomalacia, Hypophosphatemia, Hyperparathyroidism and Osteoporosis as part of general Endocrinology study is frequently linked to Osteocyte, bridging the gap between disciplines. Thomas J. Gardella has researched G protein-coupled receptor in several fields, including Biophysics, Adenylyl cyclase, Allosteric regulation and Cell signaling.
Thomas J. Gardella spends much of his time researching Receptor, Parathyroid hormone, G protein-coupled receptor, Peptide and Biophysics. Receptor and Endocrinology are frequently intertwined in his study. Thomas J. Gardella has included themes like Hormone and Kinase, Cell biology in his Parathyroid hormone study.
His Cell biology research is multidisciplinary, incorporating perspectives in Parathyroid hormone-related protein and RANKL. As part of the same scientific family, he usually focuses on Peptide, concentrating on In vivo and intersecting with Calcitriol and Kidney. His Biophysics research is multidisciplinary, incorporating elements of Plasma protein binding, Cell signaling and Transmembrane domain.
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Sustained cyclic AMP production by parathyroid hormone receptor endocytosis
Sébastien Ferrandon;Timothy N Feinstein;Marian Castro;Bin Wang.
Nature Chemical Biology (2009)
Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis
Thomas Gardella;Peter Medveczky;Takeshi Sairenji;Carel Mulder.
Journal of Virology (1984)
A mutant Escherichia coli σ70 subunit of RNA polymerase with altered promoter specificity
Thomas James Gardella;Henry Moyle;Miriam M. Susskind.
Journal of Molecular Biology (1989)
Parathyroid hormone and parathyroid hormone-related peptide, and their receptors
Robert C. Gensure;Thomas J. Gardella;Harald Jüppner.
Biochemical and Biophysical Research Communications (2005)
Receptors for PTH and pTHrP: their biological importance and functional properties
Michael Mannstadt;Harald Jüppner;Thomas J. Gardella.
American Journal of Physiology-renal Physiology (1999)
Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism.
Andrew Arnold;Susan A. Horst;Thomas J. Gardella;Hisamitsu Baba.
Journal of Clinical Investigation (1990)
Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction.
Clemens Bergwitz;Thomas J. Gardella;Merrilee R. Flannery;John T. Potts.
Journal of Biological Chemistry (1996)
Molecular properties of the PTH/PTHrP receptor.
Thomas J Gardella;Harald Jüppner.
Trends in Endocrinology and Metabolism (2001)
Retromer terminates the generation of cAMP by internalized PTH receptors
Timothy N Feinstein;Vanessa L Wehbi;Juan A Ardura;David S Wheeler.
Nature Chemical Biology (2011)
Altered Selectivity of Parathyroid Hormone (PTH) and PTH-Related Protein (PTHrP) for Distinct Conformations of the PTH/PTHrP Receptor
Thomas Dean;Jean-Pierre Vilardaga;John T. Potts;Thomas James Gardella.
Molecular Endocrinology (2008)
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