What is he best known for?
The fields of study he is best known for:
Thomas J. Gardella mainly focuses on Receptor, Parathyroid hormone, Parathyroid hormone receptor, Signal transduction and Internal medicine.
His Receptor research entails a greater understanding of Biochemistry.
His biological study spans a wide range of topics, including Molecular biology and Ligand.
His study looks at the relationship between Signal transduction and fields such as Paracrine signalling, as well as how they intersect with chemical problems.
His Internal medicine research incorporates elements of Endocrinology, Amino acid sequence homology, COS cells, Binding site and Binding selectivity.
His study in the fields of Calcitonin under the domain of Endocrinology overlaps with other disciplines such as Ligand.
His most cited work include:
- Sustained cyclic AMP production by parathyroid hormone receptor endocytosis (374 citations)
- Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis (243 citations)
- A mutant Escherichia coli σ70 subunit of RNA polymerase with altered promoter specificity (235 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Parathyroid hormone, Receptor, Endocrinology, Internal medicine and Parathyroid hormone receptor.
His work carried out in the field of Parathyroid hormone brings together such families of science as Agonist, Extracellular, Biochemistry and Transmembrane domain.
His studies in Receptor integrate themes in fields like Signal transduction, Cell biology and Peptide.
In his study, Plasma protein binding is strongly linked to Stereochemistry, which falls under the umbrella field of Peptide.
His study in Endocrinology is interdisciplinary in nature, drawing from both Calcium metabolism and Inverse agonist.
His study on Calcitonin, Hypercalciuria, Peptide hormone and Bone resorption is often connected to Osteocyte as part of broader study in Internal medicine.
He most often published in these fields:
- Parathyroid hormone (72.26%)
- Receptor (71.53%)
- Endocrinology (45.26%)
What were the highlights of his more recent work (between 2016-2021)?
- Receptor (71.53%)
- Parathyroid hormone (72.26%)
- Internal medicine (45.26%)
In recent papers he was focusing on the following fields of study:
Receptor, Parathyroid hormone, Internal medicine, Endocrinology and G protein-coupled receptor are his primary areas of study.
His work on Ligand as part of general Receptor research is often related to Parathyroid hormone receptor, thus linking different fields of science.
Thomas J. Gardella interconnects Calcium metabolism and Hormone in the investigation of issues within Parathyroid hormone.
His work on Inverse agonist, Hypoparathyroidism and Hypercalciuria as part of general Internal medicine study is frequently linked to Context, therefore connecting diverse disciplines of science.
His work on Osteomalacia, Hypophosphatemia, Hyperparathyroidism and Osteoporosis as part of general Endocrinology study is frequently linked to Osteocyte, bridging the gap between disciplines.
Thomas J. Gardella has researched G protein-coupled receptor in several fields, including Biophysics, Adenylyl cyclase, Allosteric regulation and Cell signaling.
Between 2016 and 2021, his most popular works were:
- Structure and dynamics of the active human parathyroid hormone receptor-1. (66 citations)
- Parathyroid hormone(1–34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A–CRTC3 signaling (24 citations)
- Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors (18 citations)
In his most recent research, the most cited papers focused on:
Thomas J. Gardella spends much of his time researching Receptor, Parathyroid hormone, G protein-coupled receptor, Peptide and Biophysics.
Receptor and Endocrinology are frequently intertwined in his study.
Thomas J. Gardella has included themes like Hormone and Kinase, Cell biology in his Parathyroid hormone study.
His Cell biology research is multidisciplinary, incorporating perspectives in Parathyroid hormone-related protein and RANKL.
As part of the same scientific family, he usually focuses on Peptide, concentrating on In vivo and intersecting with Calcitriol and Kidney.
His Biophysics research is multidisciplinary, incorporating elements of Plasma protein binding, Cell signaling and Transmembrane domain.
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