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Rosemary O'Connor

Rosemary O'Connor

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
9308
World Ranking
16722
National Ranking
65

Overview

Rosemary O'Connor is affiliated with University College Cork in Ireland, contributing to research principally in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Molecular Biology, Immunology, Endocrinology, Diabetes and Metabolism, Genetics, and Oncology.

The primary topics covered in O'Connor's research include Growth Hormone and Insulin-like Growth Factors, Immune cells in cancer, Epigenetics and DNA Methylation, Metabolism, Diabetes, and Cancer, Autophagy in Disease and Therapy, Histone Deacetylase Inhibitors Research, and Cellular transport and secretion.

Notable recent publications by O'Connor include:

  • IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway, 2020, Cells
  • Controlled Signaling-Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments, 2021, Frontiers in Endocrinology
  • IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr 1250 and Tyr 1251, 2020, Science Signaling
  • Prognosticating patients with necrotising otitis externa based on response to treatment, 2021, Annals of The Royal College of Surgeons of England
  • Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity, 2024, Glia

Frequent coauthors collaborating with O'Connor include Leonie Rieger, Órla T. Cox, Stéphanie Ward, Sandra O'Shea, and Grant Godsmark.

O'Connor's research has been published in a range of journals, with multiple contributions to Cancer Research, Cells, Frontiers in Endocrinology, Science Signaling, and Annals of The Royal College of Surgeons of England.

Best Publications

  • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

    Aileen M. Moloney;Rebecca J. Griffin;Suzanne Timmons;Rosemary O’Connor

  • Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

    Suzanne A. Eccles;Eric O. Aboagye;Simak Ali;Annie S. Anderson

  • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.

    Rebecca J. Griffin;Aileen Moloney;Mary Kelliher;Janet A Johnston

  • Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis

    R O'Connor;A Kauffmann-Zeh;Y Liu;S Lehar

  • Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)

    C.P. Duffy;C.J. Elliott;R.A. O'Connor;M.M. Heenan

  • Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

    Toshihiko Torigoe;Rosemary O’Connor;Daniela Santoli;John C. Reed

  • RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.

    Patrick A. Kiely;Anagha Sant;Rosemary O'Connor

  • Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts.

    Deirdre A. Buckley;Alan Cheng;Patrick A. Kiely;Michel L. Tremblay

  • PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response.

    V Ayllón;R O'Connor

  • Homing and progression patterns of childhood acute lymphoblastic leukemias in severe combined immunodeficiency mice.

    A Cesano;R O'Connor;B Lange

  • A cell viability assay based on monitoring respiration by optical oxygen sensing.

    Tomás C. O'Riordan;Deirdre Buckley;Vladimir Ogurtsov;Rosemary O'Connor

  • The Insulin-like Growth Factor-I–mTOR Signaling Pathway Induces the Mitochondrial Pyrimidine Nucleotide Carrier to Promote Cell Growth

    Suzanne Floyd;Cedric Favre;Francesco M. Lasorsa;Madeline Leahy

  • Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and β1 Integrin To Promote Cell Migration

    Patrick A. Kiely;Denise O'Gorman;Ken Luong;Dorit Ron

  • Regulation of IGF-I receptor signaling in tumor cells.

    R O'Connor

  • Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

    Patrick A. Kiely;George S. Baillie;Robert Barrett;Deirdre A. Buckley

  • Fluorescence-based cell viability screening assays using water-soluble oxygen probes.

    James Hynes;Suzanne Floyd;Aleksi E. Soini;Rosemary O'Connor

  • Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

    Donia P Macartney-Coxson;Kylie A Hood;Hong-jun Shi;Teresa Ward

  • Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth

    Gary Loughran;Nollaig C. Healy;Patrick A. Kiely;Merei Huigsloot

  • RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251

    Patrick A. Kiely;Madeline Leahy;Denise O'Gorman;Rosemary O'Connor

  • Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.

    E Kerr;C Holohan;K M McLaughlin;J Majkut

Frequent Co-Authors

Dmitri B. Papkovsky
Dmitri B. Papkovsky University College Cork
Thomas G. Cotter
Thomas G. Cotter University College Cork
Hans-Konrad Müller-Hermelink
Hans-Konrad Müller-Hermelink University of Würzburg
Rivka Ravid
Rivka Ravid Netherlands Institute for Neuroscience
George S. Baillie
George S. Baillie University of Glasgow
Martin Clynes
Martin Clynes Dublin City University
Giovanni Rovera
Giovanni Rovera University of Turin
John M. Lambert
John M. Lambert ImmunoGen (United States)
Renato Baserga
Renato Baserga Thomas Jefferson University
Fergal O'Gara
Fergal O'Gara University College Cork

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