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Biology and Biochemistry

D-Index
59
Citations
15725
World Ranking
12369
National Ranking
5294

Overview

Asha S. Multani is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with focused subfields including molecular biology, oncology, genetics, cancer research, and immunology.

Multani's scientific contributions cover key topics such as cancer-related molecular pathways, cancer genomics and diagnostics, epigenetics and DNA methylation, interferon and immune responses, RNA modifications and cancer, genomics and phylogenetic studies, and single-cell and spatial transcriptomics.

They have published notable research articles including:

  • 3D genomics across the tree of life reveals condensin II as a determinant of architecture type, 2021, Science
  • Breast tumours maintain a reservoir of subclonal diversity during expansion, 2021, Nature
  • Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma, 2020, Cancer Cell
  • The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling, 2020, Gastroenterology
  • APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis, 2021, Nature Cancer

Multani frequently collaborates with other researchers, including Sen Pathak, Olga Dudchenko, David Weisz, Arina D. Omer, and Ruqayya Khan.

Their work has appeared in several prominent scientific venues, with multiple publications in Cancer Research, Nature, bioRxiv (Cold Spring Harbor Laboratory), Science, and Cancer Cell.

Best Publications

  • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

    Sunil R. Hingorani;Lifu Wang;Asha S. Multani;Chelsea Combs

  • Clonal evolution in breast cancer revealed by single nucleus genome sequencing

    Yong Wang;Jill Waters;Marco L. Leung;Anna Unruh

  • CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

    Hui Ling;Riccardo Spizzo;Yaser Atlasi;Milena Nicoloso

  • Essential role of limiting telomeres in the pathogenesis of Werner syndrome.

    Sandy Chang;Asha S Multani;Noelia G Cabrera;Maria L Naylor

  • Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.

    Ling Wu;Asha S. Multani;Hua He;Wilfredo Cosme-Blanco

  • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.

    Geng Liu;John M Parant;Gene Lang;Patty Chau

  • Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence

    Wilfredo Cosme-Blanco;Mei Feng Shen;Alexander J.F. Lazar;Sen Pathak

  • Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

    Ana C. Decarvalho;Hoon Kim;Laila M. Poisson;Mary E. Winn

  • Control of chromosome stability by the β-TrCP-REST-Mad2 axis

    Daniele Guardavaccaro;David Frescas;N. Valerio Dorrello;Angelo Peschiaroli

  • Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

    Purnima R. Laud;Asha S. Multani;Susan M. Bailey;Ling Wu

  • Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

    Vasudevan Achuthan;Jill M. Perreira;Gregory A. Sowd;Maritza Puray-Chavez

  • Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer.

    Said Akli;Ping Ju Zheng;Asha S. Multani;Hannah F. Wingate;Hannah F. Wingate

  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.

    Jiang Shou;Francis Ali-Osman;Asha S Multani;Sen Pathak

  • Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

    Boyko S. Atanassov;Yvonne A. Evrard;Asha S. Multani;Zhijing Zhang

  • The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

    Rekha Rai;Hong Zheng;Hua He;Ying Luo

  • BRIT1 regulates early DNA damage response, chromosomal integrity,and cancer

    Rekha Rai;Hui Dai;Asha S. Multani;Kaiyi Li

  • Androgen receptor–negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms

    Zhi Gang Li;Paul Mathew;Jun Yang;Michael W. Starbuck

  • 3D genomics across the tree of life reveals condensin II as a determinant of architecture type

    Claire Hoencamp;Olga Dudchenko;Olga Dudchenko;Ahmed M.O. Elbatsh;Sumitabha Brahmachari

  • KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.

    Klaus W. Wagner;Hunain Alam;Shilpa S. Dhar;Uma Giri

  • Breast tumours maintain a reservoir of subclonal diversity during expansion

    Darlan C. Minussi;Michael D. Nicholson;Hanghui Ye;Alexander Davis

Frequent Co-Authors

Sen Pathak
Sen Pathak The University of Texas MD Anderson Cancer Center
Sandy Chang
Sandy Chang Yale University
Funda Meric-Bernstam
Funda Meric-Bernstam The University of Texas MD Anderson Cancer Center
Leland W.K. Chung
Leland W.K. Chung Cedars-Sinai Medical Center
Carlos E. Bueso-Ramos
Carlos E. Bueso-Ramos The University of Texas MD Anderson Cancer Center
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Mien Chie Hung
Mien Chie Hung China Medical University
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Haiyen E. Zhau
Haiyen E. Zhau Cedars-Sinai Medical Center
Ken Chen
Ken Chen The University of Texas MD Anderson Cancer Center

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