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Biology and Biochemistry

D-Index
64
Citations
17559
World Ranking
9530
National Ranking
181

Overview

Juana M. Flores is affiliated with the Complutense University of Madrid in Spain. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on molecular biology, physiology, oncology, pulmonary and respiratory medicine, and infectious diseases.

The scientist's work concentrates on several key topics including telomeres, telomerase, and senescence; sexual function and dysfunction studies; employee performance and management; employee performance and leadership; genetics, aging, and longevity in model organisms; immune cells in cancer; and prostate cancer treatment and research.

Juana M. Flores has published multiple articles in respected scientific journals. Their recent papers include:

  • The mTOR pathway is necessary for survival of mice with short telomeres (2020, Nature Communications)
  • Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment (2022, Journal of Clinical Investigation)
  • SOX9 promotes tumor progression through the axis BMI1-p21CIP (2020, Scientific Reports)
  • Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer (2020, The Journal of Experimental Medicine)
  • The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis (2020, Scientific Reports)

Frequent publication venues for the scientist include:

  • Nature Communications
  • Scientific Reports
  • Actas Urológicas Españolas (English Edition)
  • European Urology Open Science
  • The Journal of Sexual Medicine

Collaboration plays a role in their work, with frequent co-authors being María A. Blasco, Paula Martínez, Rosa Serrano, Sarita Saraswati, and Arkaitz Carracedo.

Best Publications

  • Tumour biology: Senescence in premalignant tumours

    Manuel Collado;Jesús Gil;Alejo Efeyan;Carmen Guerra

  • The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

    Angeles Duran;Juan F. Linares;Anita S. Galvez;Kathryn Wikenheiser

  • "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.

    Isabel García-Cao;Marta García-Cao;Juan Martín-Caballero;Luis M. Criado

  • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

    Eloísa Herrera;Enrique Samper;Juan Martín-Caballero;Juana M. Flores

  • Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

    Antonia Tomás-Loba;Ignacio Flores;Pablo J. Fernández-Marcos;María L. Cayuela

  • Delayed ageing through damage protection by the Arf/p53 pathway

    Ander Matheu;Antonio Maraver;Peter Klatt;Ignacio Flores

  • Tumor susceptibility of p21waf1/cip1-deficient mice

    Juan Martín-Caballero;Juana M. Flores;Pilar García-Palencia;Manuel Serrano

  • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

    Eva González-Suárez;Enrique Samper;Angel Ramírez;Juana M. Flores

  • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

    Eva González-Suárez;Enrique Samper;Juana M. Flores;María A. Blasco

  • Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

    Paula Martínez;Maria Thanasoula;Purificación Muñoz;Chunyan Liao

  • PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

    Domingo F Barber;Almira Bartolomé;Carmen Hernandez;Juana M Flores

  • The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

    Angeles Durán;Manuel Serrano;Michael Leitges;Juana M Flores

  • Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

    Angelina Rodriguez;Angeles Durán;Mohammed Selloum;Marie-France Champy

  • Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc -/- mice with short telomeres

    Enrique Samper;Juana M Flores;María A Blasco

  • Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis

    Esther Latres;Marcos Malumbres;Marcos Malumbres;Rocío Sotillo;Rocío Sotillo;Javier Martín;Javier Martín

  • XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

    Purificación Muñoz;Raquel Blanco;Juana M Flores;María A Blasco

  • Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals

    Fermín A. Goytisolo;Enrique Samper;Juan Martín-Caballero;Paul Finnon

  • SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells

    David Olmeda;Gema Moreno-Bueno;Juana María Flores;Àngels Fabra

  • The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

    Dimitrios Balomenos;Juan Martín-Caballero;Maria I. García;Ignacio Prieto

  • Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: clinical and pathologic associations and prognostic significance.

    A. Nieto;L. Peña;M. D. Pérez-Alenza;M. A. Sánchez

Frequent Co-Authors

Maria A. Blasco
Maria A. Blasco Spanish National Cancer Research Centre
Manuel Serrano
Manuel Serrano Institució Catalana de Recerca i Estudis Avançats
Antonio Gonzalez-Bulnes
Antonio Gonzalez-Bulnes Complutense University of Madrid
Peter Klatt
Peter Klatt Spanish National Research Council
Carlos Martínez-A
Carlos Martínez-A Spanish National Research Council
Arkaitz Carracedo
Arkaitz Carracedo University of the Basque Country
Lisardo Boscá
Lisardo Boscá Autonomous University of Madrid
Ana C. Carrera
Ana C. Carrera Spanish National Research Council
Mariano Barbacid
Mariano Barbacid Spanish National Cancer Research Centre
Guillermo Velasco
Guillermo Velasco Complutense University of Madrid

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