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Biology and Biochemistry

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81
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3917
National Ranking
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Medicine

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Overview

Yasuhide Hayashi is affiliated with Gunma Children's Medical Center in Japan and has contributed extensively to medical research, with a focus on hematology and molecular biology among other fields. Their research portfolio includes over fifty publications primarily in medicine and biochemistry, genetics, and molecular biology.

Their subfields of study emphasize hematology, molecular biology, and genetics, supplemented by research in public health, environmental and occupational health, and cancer research.

Hayashi's key research topics include acute myeloid leukemia research, myeloproliferative neoplasms, acute lymphoblastic leukemia research, epigenetics and DNA methylation, protein degradation and inhibitors, histone deacetylase inhibitors research, and chronic myeloid leukemia treatments.

Frequent co-authors collaborating with Hayashi encompass Genki Yamato, Norio Shiba, Daisuke Tomizawa, Kenichi Yoshida, and Takashi Taga.

The scientist's work appears often in several prominent journals, including Blood, Genes Chromosomes and Cancer, Leukemia, Haematologica, and the British Journal of Haematology.

Representative recent publications by Hayashi include:

  • Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets (2020) in npj Precision Oncology
  • Impact of immunophenotypic characteristics on genetic subgrouping in childhood acute lymphoblastic leukemia: Tokyo Children's Cancer Study Group (TCCSG) study L04-16 (2020) in Genes Chromosomes and Cancer
  • Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia (2021) in Haematologica
  • Predictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome (2021) in Leukemia
  • UBTF-internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia (2022) in Genes Chromosomes and Cancer

Best Publications

  • Oncogenic mutations of ALK kinase in neuroblastoma.

    Yuyan Chen;Junko Takita;Young Lim Choi;Motohiro Kato

  • Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ

    Chunjie Zhao;Junko Takita;Yosuke Tanaka;Mitsutoshi Setou

  • Frequent inactivation of A20 in B-cell lymphomas

    Motohiro Kato;Masashi Sanada;Itaru Kato;Yasuharu Sato

  • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

    Masashi Sanada;Takahiro Suzuki;Lee-Yung Shih;Makoto Otsu

  • The landscape of somatic mutations in Down syndrome-related myeloid disorders

    Kenichi Yoshida;Tsutomu Toki;Yusuke Okuno;Rika Kanezaki

  • LCX, Leukemia-associated Protein with a CXXC Domain, Is Fused to MLL in Acute Myeloid Leukemia with Trilineage Dysplasia Having t(10;11)(q22;q23)

    Ryoichi Ono;Tomohiko Taki;Takeshi Taketani;Masafumi Taniwaki

  • An RNA-binding Protein Gene, TLS/FUS , Is Fused to ERG in Human Myeloid Leukemia with t(16;21) Chromosomal Translocation

    Hitoshi Ichikawa;Kimiko Shimizu;Yasuhide Hayashi;Misao Ohki

  • Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13).

    Kohmei Ida;Issay Kitabayashi;Tomohiko Taki;Masafumi Taniwaki

  • The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene.

    Tomohiko Taki;Masahiro Sako;Masahiro Tsuchida;Yasuhide Hayashi

  • FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

    Takeshi Taketani;Tomohiko Taki;Kanji Sugita;Yoshiyuki Furuichi

  • An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

    Tanja A. Gruber;Amanda Larson Gedman;Jinghui Zhang;Cary S. Koss

  • The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family

    Toshie Gamou;Eiko Kitamura;Fumie Hosoda;Kimiko Shimizu

  • Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children.

    F. Xu;T. Taki;H. W. Yang;R. Hanada

  • Spontaneous regression of localized neuroblastoma detected by mass screening.

    Keiko Yamamoto;Ryoji Hanada;Akira Kikuchi;Masataka Ichikawa

  • KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group

    Akira Shimada;Tomohiko Taki;Ken Tabuchi;Akio Tawa

  • Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia

    Takeyuki Sato;Akira Fuse;Mitsuoki Eguchi;Yasuhide Hayashi

  • The inv(11)(p15q22) Chromosome Translocation of De Novo and Therapy-Related Myeloid Malignancies Results in Fusion of the Nucleoporin Gene, NUP98, With the Putative RNA Helicase Gene, DDX10

    Yasuhito Arai;Fumie Hosoda;Hirofumi Kobayashi;Kyoko Arai

  • Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome.

    Gang Xu;Masumi Nagano;Rika Kanezaki;Tsutomu Toki

  • Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein–Taybi syndrome

    Takashi Murata;Riki Kurokawa;Anna Krones;Ken Tatsumi

  • Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

    Sahoko Matsuoka;Yuichi Oike;Yuichi Oike;Ichiro Onoyama;Atsushi Iwama

Frequent Co-Authors

Tomohiko Taki
Tomohiko Taki Kyorin University
Seishi Ogawa
Seishi Ogawa Kyoto University
Souichi Adachi
Souichi Adachi Shiga Prefectural General Hospital
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University
Yuichi Shiraishi
Yuichi Shiraishi University of Tokyo
Masashi Sanada
Masashi Sanada Kyoto University
Etsuro Ito
Etsuro Ito Hirosaki University
Akira Kikuchi
Akira Kikuchi Osaka University
Seiji Kojima
Seiji Kojima Nagoya University
kenichi yoshida
kenichi yoshida Kyoto University

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