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Genetics

D-Index
45
Citations
8980
World Ranking
4218
National Ranking
477

Overview

David Strutt is a researcher affiliated with the University of Sheffield in the United Kingdom, working primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields including Cell Biology, Molecular Biology, Biophysics, Cellular and Molecular Neuroscience, and Biomedical Engineering.

Their research focuses on various topics within cellular and molecular systems, with key areas including:

  • Cellular Mechanics and Interactions
  • Hippo pathway signaling and YAP/TAZ
  • Wnt/β-catenin signaling in development and cancer
  • Developmental Biology and Gene Regulation
  • Advanced Fluorescence Microscopy Techniques
  • Microtubule and mitosis dynamics
  • Cellular transport and secretion

David Strutt has published extensively, contributing to the following research venues on multiple occasions:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Current Biology
  • Cell Reports
  • Zenodo (CERN European Organization for Nuclear Research)
  • eLife

Selected recent publications include:

  • "How do the Fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?" (2021, Open Biology)
  • "Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins" (2020, Biochemical Society Transactions)
  • "QuantifyPolarity, a new tool-kit for measuring planar polarized protein distributions and cell properties in developing tissues" (2021, Development)
  • "Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides" (2024, The Journal of Cell Biology)
  • "Molecular symmetry breaking in the Frizzled-dependent planar polarity pathway" (2023, Current Biology)

Frequent collaborators in their research include:

  • Helen Strutt
  • Samantha J. Warrington
  • Su Tan
  • Ashley J. Cadby
  • Robert Hunton

Their combined contributions cover a considerable number of publications in cell biology and related molecular mechanisms. Their research often addresses fundamental processes of cellular polarity, signaling pathways, and advanced imaging techniques to understand cellular behavior and development at the molecular level.

Best Publications

  • Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

    Michael Boutros;Nuria Paricio;David I Strutt;Marek Mlodzik

  • The role of RhoA in tissue polarity and Frizzled signalling.

    David I. Strutt;Ursula Weber;Marek Mlodzik

  • Principles of planar polarity in animal development.

    Lisa V. Goodrich;David Strutt

  • Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning.

    Rebecca Bastock;Helen Strutt;David Strutt

  • Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing.

    David I Strutt

  • Frizzled signalling and cell polarisation in Drosophila and vertebrates.

    David Strutt

  • Polarized Transport of Frizzled along the Planar Microtubule Arrays in Drosophila Wing Epithelium

    Yuko Shimada;Shigenobu Yonemura;Hiroyuki Ohkura;David Strutt

  • Nonautonomous Planar Polarity Patterning in Drosophila: Dishevelled-Independent Functions of Frizzled

    Helen Strutt;David Strutt

  • Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye.

    Manolis Fanto;Manolis Fanto;Ursula Weber;Ursula Weber;David I. Strutt;David I. Strutt;Marek Mlodzik;Marek Mlodzik

  • Targets of homeotic gene control in Drosophila.

    Alex P. Gould;Jenny J. Brookman;David I. Strutt;Robert A. H. White

  • Polarity determination in the Drosophila eye: a novel role for Unpaired and JAK/STAT signaling

    Martin P. Zeidler;Norbert Perrimon;David I. Strutt

  • Differential Stability of Flamingo Protein Complexes Underlies the Establishment of Planar Polarity

    Helen Strutt;David Strutt

  • Asymmetric Localization of Frizzled and the Determination of Notch-Dependent Cell Fate in the Drosophila Eye

    David Strutt;Ruth I. Johnson;Katherine Cooper;Sarah J. Bray

  • Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat.

    Amy L. Brittle;Ada Repiso;Ada Repiso;José Casal;Peter A. Lawrence;Peter A. Lawrence

  • Dynamics of Core Planar Polarity Protein Turnover and Stable Assembly into Discrete Membrane Subdomains

    Helen Strutt;Samantha J. Warrington;David Strutt

  • The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification

    Martin P. Zeidler;Norbert Perrimon;David I. Strutt

  • Multiple roles for four-jointed in planar polarity and limb patterning.

    Martin P Zeidler;Norbert Perrimon;Norbert Perrimon;David I Strutt

  • Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous.

    Amy Brittle;Chloe Thomas;David Strutt

  • Asymmetric localisation of planar polarity proteins: Mechanisms and consequences

    Helen Strutt;David Strutt

  • Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A.

    David I. Strutt;Volker Wiersdorff;Marek Mlodzik

Frequent Co-Authors

Marek Mlodzik
Marek Mlodzik Icahn School of Medicine at Mount Sinai
Norbert Perrimon
Norbert Perrimon Harvard University
Peter A. Lawrence
Peter A. Lawrence University of Cambridge
Andrew P. Jackson
Andrew P. Jackson University of Edinburgh
Philip W. Ingham
Philip W. Ingham University of Bath
Michael Boutros
Michael Boutros German Cancer Research Center
Ralf Schnabel
Ralf Schnabel Technische Universität Braunschweig
Enrico Coen
Enrico Coen John Innes Centre
Timothy P. Levine
Timothy P. Levine University College London
Jean-Paul Vincent
Jean-Paul Vincent The Francis Crick Institute

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