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Biology and Biochemistry

D-Index
53
Citations
18290
World Ranking
15912
National Ranking
6611

Overview

Barbara Fingleton is affiliated with Vanderbilt University in the United States. Their research spans multiple interconnected fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. The scientist is active across several subfields such as Immunology, Molecular Biology, Oncology, Cancer Research, and Biotechnology.

Fingleton's work focuses on key topics within cancer biology, emphasizing Cancer Research and Treatments, Cancer, Hypoxia, and Metabolism, as well as Cancer Immunotherapy and Biomarkers. Additional research interests include RNA modifications and cancer, Neuroinflammation and Neurodegeneration Mechanisms, Immune cells in cancer, and Glycosylation and Glycoproteins Research.

Their publication record includes contributions to a variety of journals, with frequent appearances in Cancer Research, Frontiers in Oncology, Clinical & Experimental Metastasis, International Journal of Molecular Sciences, and Nature Biomedical Engineering.

  • The therapeutic potential of TREM2 in cancer (2022, Frontiers in Oncology)
  • Glycosylation as a regulator of site-specific metastasis (2021, Cancer and Metastasis Reviews)
  • Sex Hormones in Breast Cancer Immunity (2022, Cancer Research)
  • Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates (2025, Nature Biomedical Engineering)
  • Development of a novel murine model of lymphatic metastasis (2020, Clinical & Experimental Metastasis)

Frequent coauthors of Fingleton include Ebony Hargrove-Wiley, Wendy Bindeman, Demond Williams, Jacob A. Beckstead, and Alyssa H. Hasty.

Best Publications

  • Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

    Lisa M. Coussens;Barbara Fingleton;Lynn M. Matrisian

  • Matrix Metalloproteinases: Biologic Activity and Clinical Implications

    Amy R. Nelson;Barbara Fingleton;Mace L. Rothenberg;Lynn M. Matrisian

  • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

    Li Yang;Laura M. DeBusk;Koari Fukuda;Barbara Fingleton

  • The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

    Howard C. Crawford;Barbara M. Fingleton;Laura A. Rudolph-Owen;Kathleen J. Heppner Goss;Kathleen J. Heppner Goss

  • Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

    Veerle Noë;Barbara Fingleton;Kathleen Jacobs;Howard C. Crawford

  • The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

    William C. Powell;Barbara Fingleton;Carole L. Wilson;Mark Boothby

  • Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption

    Hirotaka Haro;Howard C. Crawford;Barbara Fingleton;Kenichi Shinomiya

  • MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL

    Conor C. Lynch;Atsuya Hikosaka;Heath B. Acuff;Michelle D. Martin

  • Moving targets: Emerging roles for MMPs in cancer progression and metastasis.

    Gemma Shay;Conor C. Lynch;Barbara Fingleton

  • Matrix metalloproteinases: roles in cancer and metastasis.

    Barbara Fingleton

  • Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

    Fazilat F Mohammed;David S Smookler;Suzanne E M Taylor;Barbara Fingleton

  • MMPs as therapeutic targets—Still a viable option?

    Barbara Fingleton

  • Matrix metalloproteinases as valid clinical targets

    Barbara Fingleton

  • Matrix metalloproteinase-3–dependent generation of a macrophage chemoattractant in a model of herniated disc resorption

    Hirotaka Haro;Howard C. Crawford;Barbara Fingleton;John R. MacDougall

  • Matrix metalloproteinases as regulators of inflammatory processes.

    Barbara Fingleton

  • Epithelial NF-κB activation promotes urethane-induced lung carcinogenesis

    Georgios T. Stathopoulos;Taylor P. Sherrill;Dong-Sheng Cheng;Robert M. Scoggins

  • Matrix Metalloproteinase-9 from Bone Marrow–Derived Cells Contributes to Survival but not Growth of Tumor Cells in the Lung Microenvironment

    Heath B. Acuff;Kathy J. Carter;Barbara Fingleton;D. Lee Gorden

  • The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

    Howard C. Crawford;Barbara Fingleton;Mark D. Gustavson;Natasza Kurpios

  • Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.

    Barbara Fingleton;Tracy Vargo-Gogola;Howard C. Crawford;Lynn M. Matrisian

  • Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity

    J. Oliver McINTYRE;Barbara Fingleton;K. Sam Wells;David W. Piston

Frequent Co-Authors

Lynn M. Matrisian
Lynn M. Matrisian Vanderbilt University
Howard C. Crawford
Howard C. Crawford University of Michigan–Ann Arbor
Timothy S. Blackwell
Timothy S. Blackwell University of Michigan–Ann Arbor
Fiona E. Yull
Fiona E. Yull Vanderbilt University
Keith T. Wilson
Keith T. Wilson Vanderbilt University Medical Center
James R. Goldenring
James R. Goldenring Vanderbilt University
Ambra Pozzi
Ambra Pozzi Vanderbilt University Medical Center
Rupesh Chaturvedi
Rupesh Chaturvedi Jawaharlal Nehru University
David W. Piston
David W. Piston Washington University in St. Louis
Richard M. Peek
Richard M. Peek Vanderbilt University Medical Center

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