Thomas Spies

What is he best known for?

The fields of study he is best known for:

• Gene
• DNA
• Immune system

Thomas Spies spends much of his time researching Cell biology, NKG2D, Natural killer cell, Major histocompatibility complex and Immunology. Thomas Spies has included themes like Natural killer T cell, MHC class I and Antigen presentation in his Cell biology study. NKG2D is a subfield of Cytotoxic T cell that Thomas Spies investigates.

His work carried out in the field of Natural killer cell brings together such families of science as CD8 and Effector. He regularly ties together related areas like Molecular biology in his Major histocompatibility complex studies. His work in the fields of Immunology, such as Interleukin 21 and CTL*, overlaps with other areas such as Mica, Ligand and Monomer.

His most cited work include:

• Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. (2501 citations)
• Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation (1266 citations)
• An activating immunoreceptor complex formed by NKG2D and DAP10. (929 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in NKG2D, MHC class I, Major histocompatibility complex, Genetics and Immunology. His NKG2D research is multidisciplinary, relying on both Natural killer cell, Interleukin 21, IL-2 receptor and Lymphocyte. His MHC class I research incorporates themes from Molecular biology and Cell biology.

His work focuses on many connections between Cell biology and other disciplines, such as CD8, that overlap with his field of interest in Immune receptor. He has researched Major histocompatibility complex in several fields, including Peptide sequence, Internal medicine and Histocompatibility. His research integrates issues of Cancer, Cancer research and Interleukin 15 in his study of Immunology.

He most often published in these fields:

• NKG2D (34.19%)
• MHC class I (33.33%)
• Major histocompatibility complex (29.91%)

What were the highlights of his more recent work (between 2006-2017)?

• NKG2D (34.19%)
• Immunology (29.06%)
• Cell biology (28.21%)

In recent papers he was focusing on the following fields of study:

Thomas Spies mostly deals with NKG2D, Immunology, Cell biology, Cancer research and Immune system. His NKG2D study combines topics in areas such as Natural killer cell, Molecular biology, Cytolysis, Regulation of gene expression and Effector. His study in Natural killer cell is interdisciplinary in nature, drawing from both Adenoviridae, Viral vector and CD8.

His biological study spans a wide range of topics, including Cytotoxic T cell and Interleukin 15. His Cell biology research is multidisciplinary, incorporating elements of Major histocompatibility complex and Nkg2d ligands. The Major histocompatibility complex study combines topics in areas such as Protein structure and Internal medicine.

Between 2006 and 2017, his most popular works were:

• Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands (298 citations)
• Promoter Region Architecture and Transcriptional Regulation of the Genes for the MHC Class I-Related Chain A and B Ligands of NKG2D (165 citations)
• Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus (89 citations)

In his most recent research, the most cited papers focused on:

• Gene
• DNA
• Immune system

His primary scientific interests are in NKG2D, Immunology, Cytotoxic T cell, Major histocompatibility complex and Cell biology. His NKG2D research is multidisciplinary, incorporating perspectives in Promoter, Regulation of gene expression, Transcriptional regulation and Molecular biology. Many of his research projects under Immunology are closely connected to Phospholipase A2 with Phospholipase A2, tying the diverse disciplines of science together.

As part of his studies on Cytotoxic T cell, Thomas Spies often connects relevant subjects like T cell. His Major histocompatibility complex research includes elements of Natural killer cell, Adenoviridae, Cell culture and Virology. His work on Effector, Endoplasmic reticulum and Protein disulfide-isomerase as part of general Cell biology research is frequently linked to Population, thereby connecting diverse disciplines of science.