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Immunology

D-Index
83
Citations
24981
World Ranking
1443
National Ranking
96

Overview

Alma Zernecke is affiliated with the University of Würzburg in Germany. Their research contributes primarily to the fields of medicine and immunology and microbiology, with a substantial body of work also intersecting molecular biology, cardiology and cardiovascular medicine, oncology, and surgery.

The main topics of their research focus on atherosclerosis and cardiovascular diseases, immune cells in cancer, single-cell and spatial transcriptomics, immune cell function and interaction, cardiac fibrosis and remodeling, T-cell and B-cell immunology, and phagocytosis and immune regulation.

Frequent coauthors in their work include Clément Cochain, Antoine-Emmanuel Saliba, Giuseppe Rizzo, Sarah Schäfer, and Sourish Reddy Bandi.

Zernecke has published extensively in several scientific venues. The most common publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Cardiovascular Research, Nature Communications, Circulation Research, and Blood.

Among the notable recent publications authored by Alma Zernecke are:

  • Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas, 2020, Circulation Research
  • Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis, 2022, Cardiovascular Research

Other significant papers in related fields include:

  • Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction, 2020, Circulation Research (coauthor)
  • Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming, 2023, Nature Communications (coauthor)
  • Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq, 2021, Cardiovascular Research (coauthor)

Zernecke's research involves advanced methodologies including single-cell and spatial transcriptomics, which facilitate deeper understanding of immune cell diversity and function within cardiovascular and oncological contexts. Their work often addresses cellular heterogeneity in disease states such as atherosclerosis and myocardial infarction.

Best Publications

  • Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection

    Alma Zernecke;Kiril Bidzhekov;Heidi Noels;Erdenechimeg Shagdarsuren

  • MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

    Jürgen Bernhagen;Regina Krohn;Hongqi Lue;Julia L Gregory

  • The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

    Christian Weber;Alma Zernecke;Peter Libby

  • Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis

    Clément Cochain;Ehsan Vafadarnejad;Panagiota Arampatzi;Jaroslav Pelisek

  • JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.

    Georg Ostermann;Kim S. C. Weber;Alma Zernecke;Andreas Schröder

  • CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

    Limor Landsman;Liat Bar-On;Alma Zernecke;Ki-Wook Kim

  • Neutrophil secretion products pave the way for inflammatory monocytes

    Oliver Soehnlein;Alma Zernecke;Einar E. Eriksson;Antonio Gigliotti Rothfuchs

  • Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

    Holger Winkels;Erik Ehinger;Melanie Vassallo;Konrad Buscher

  • Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

    Alma Zernecke;Ilze Bot;Yassin Djalali-Talab;Erdenechimeg Shagdarsuren

  • Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.

    Rory R Koenen;Philipp von Hundelshausen;Irina V Nesmelova;Alma Zernecke

  • Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

    Yvonne Döring;Helga D. Manthey;Maik Drechsler;Dirk Lievens

  • Platelet Microparticles: A Transcellular Delivery System for RANTES Promoting Monocyte Recruitment on Endothelium

    Sebastian F. Mause;Philipp von Hundelshausen;Alma Zernecke;Rory R. Koenen

  • SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells

    Alma Zernecke;Andreas Schober;Ilze Bot;Philipp von Hundelshausen

  • Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

    Christoph Kleinschnitz;Peter Kraft;Angela Dreykluft;Ina Hagedorn

  • Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice

    Ilize Bot;Saskia C. A. De Jager;Aima Zernecke;Ken A. Lindstedt

  • Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

    Henning W. Zimmermann;Sebastian Seidler;Jacob Nattermann;Nikolaus Gassler

  • Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.

    Alma Zernecke;Holger Winkels;Clément Cochain;Jesse W. Williams

  • Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

    Vincent Braunersreuther;Alma Zernecke;Claire Arnaud;Elisa A. Liehn

  • Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

    Dirk Lievens;Dirk Lievens;Alma Zernecke;Tom Seijkens;Oliver Soehnlein

  • Chemokines. Key Regulators of Mononuclear Cell Recruitment in Atherosclerotic Vascular Disease

    Christian Weber;Andreas Schober;Alma Zernecke

  • Macrophage Migration Inhibitory Factor in Cardiovascular Disease

    Alma Zernecke;Jürgen Bernhagen;Christian Weber

  • CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

    Christian Weber;Svenja Meiler;Yvonne Döring;Miriam Koch

  • Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

    Esther Lutgens;Esther Lutgens;Dirk Lievens;Dirk Lievens;Linda Beckers;Erwin Wijnands

  • Targeted Disruption of cd73/Ecto-5′-Nucleotidase Alters Thromboregulation and Augments Vascular Inflammatory Response

    Patrycja Koszalka;Burcin Özüyaman;Yuqing Huo;Alma Zernecke

  • Chemokines in the vascular inflammatory response of atherosclerosis

    Alma Zernecke;Alma Zernecke;Christian Weber;Christian Weber

  • Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

    Pieter Goossens;Marion J.J. Gijbels;Alma Zernecke;Wouter Eijgelaar

  • Chemokines in Atherosclerosis Proceedings Resumed

    Alma Zernecke;Christian Weber

Frequent Co-Authors

Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Oliver Soehnlein
Oliver Soehnlein University of Münster
Esther Lutgens
Esther Lutgens Ludwig-Maximilians-Universität München
Mat J.A.P. Daemen
Mat J.A.P. Daemen University of Amsterdam
Tilman M. Hackeng
Tilman M. Hackeng Maastricht University
Menno P.J. de Winther
Menno P.J. de Winther University of Amsterdam
Bernhard Nieswandt
Bernhard Nieswandt University of Würzburg
Erik A.L. Biessen
Erik A.L. Biessen Maastricht University
Joachim Jankowski
Joachim Jankowski RWTH Aachen University
Christoph Kleinschnitz
Christoph Kleinschnitz University of Duisburg-Essen

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