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Genetics

D-Index
73
Citations
36263
World Ranking
2001
National Ranking
911

Overview

Teepu Siddique is affiliated with Northwestern University in the United States. Their research primarily focuses on Medicine, with significant contributions to Biochemistry, Genetics, and Molecular Biology. Siddique's work has explored various subfields including Neurology, Molecular Biology, Genetics, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's research covers important topics such as Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, Parkinson's Disease Mechanisms and Treatments, Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Muscle Physiology and Disorders, and Neurological Diseases and Metabolism.

Some of the recent papers authored or co-authored by Siddique include:

  • "Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity" (2020, Neuron)
  • "ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function" (2020, Proceedings of the National Academy of Sciences)
  • "The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration" (2022, Nature Communications)
  • "Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS" (2021, Communications Biology)
  • "Autologous Hematopoietic Stem Cell Transplantation for Stiff-Person Spectrum Disorder" (2020, Neurology)

The frequent co-authors working with Siddique include Nailah Siddique, Christopher E. Shaw, Kelly L. Williams, Lyndal Henden, and Garth A. Nicholson.

Siddique's publications appear regularly in several scientific venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The American Journal of Human Genetics
  • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  • Neurology Genetics

Best Publications

  • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.

    Mark E. Gurney;Haifeng Pu;Arlene Y. Chiu;Mauro C. Dal Canto

  • Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

    T. J. Kwiatkowski;D. A. Bosco;D. A. Bosco;A. L. LeClerc;A. L. LeClerc;E. Tamrazian

  • Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

    Han Xiang Deng;Afif Hentati;John A. Tainer;Zafar Iqbal

  • Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

    Han-Xiang Deng;Wenjie Chen;Seong‐Tshool Hong;Seong‐Tshool Hong;Kym M Boycott

  • Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

    Ian R.A. Mackenzie;Eileen H. Bigio;Paul G. Ince;Felix Geser

  • The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.

    Yi Yang;Afif Hentati;Han Xiang Deng;Omar Dabbagh

  • SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.

    Faisal Fecto;Jianhua Yan;S. Pavan Vemula;Erdong Liu

  • Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.

    Jenny S. Henkel;Joseph I. Engelhardt;László Siklós;Ericka P. Simpson

  • Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

    Han Xiang Deng;Yong Shi;Yoshiaki Furukawa;Hong Zhai

  • Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity.

    T Siddique;D A Figlewicz;D A Figlewicz;M A Pericak-Vance;J L Haines

  • Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3

    Caroline Vance;Ammar Al-Chalabi;Deborah Ruddy;Bradley N. Smith

  • Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22

    Betsy A. Hosler;Teepu Siddique;Peter C. Sapp;Peter C. Sapp;Wen Sailor;Wen Sailor

  • Intense Superoxide Dismutase-1 Immunoreactivity in Intracytoplasmic Hyaline Inclusions of Familial Amyotrophic Lateral Sclerosis with Posterior Column Involvement

    Noriyuki Shibata;Asao Hirano;Makio Kobayashi;Teepu Siddique

  • Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.

    Gabriele Grenningloh;Volker Schmieden;Peter R. Schofield;Peter H. Seeburg

  • Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4.

    Han Xiang Deng;Christopher J. Klein;Jianhua Yan;Yong Shi

  • Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33–q35

    Afif Hentati;Khemissa Bejaoui;Margaret A. Pericak-Vance;Faycal Hentati

  • Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice.

    Yoshiaki Furukawa;Ronggen Fu;Han Xiang Deng;Teepu Siddique

  • Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

    Afif Hentati;Karim Ouahchi;Margaret A. Pericak-Vance;Deepak Nijhawan

  • Increased persistent Na+ current and its effect on excitability in motoneurones cultured from mutant SOD1 mice

    J. J. Kuo;T. Siddique;R. Fu;C. J. Heckman

  • Genetics of amyotrophic lateral sclerosis.

    Teepu Siddique;Han Xiang Deng

Frequent Co-Authors

Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami
Jonathan L. Haines
Jonathan L. Haines Case Western Reserve University
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital
Raymond P. Roos
Raymond P. Roos University of Chicago
Christopher Shaw
Christopher Shaw King's College London
Marcy C. Speer
Marcy C. Speer Duke University
Ammar Al-Chalabi
Ammar Al-Chalabi King's College London
Jeffery M. Vance
Jeffery M. Vance University of Miami
Charles J. Heckman
Charles J. Heckman Northwestern University
Peter M Andersen
Peter M Andersen Umeå University

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