Teepu Siddique focuses on Amyotrophic lateral sclerosis, Genetics, SOD1, Mutation and Genetic linkage. His work on TARDBP and UBQLN2 as part of general Amyotrophic lateral sclerosis research is frequently linked to RNA-Binding Protein FUS, thereby connecting diverse disciplines of science. His study explores the link between Genetics and topics such as Frontotemporal dementia that cross with problems in Penetrance and Haplotype.
His SOD1 research incorporates elements of Genetically modified mouse and Hyaline inclusion. His Mutation research incorporates themes from Internal medicine, Neurodegeneration, Endocrinology and Age of onset. He focuses mostly in the field of Genetic linkage, narrowing it down to topics relating to Chromosome 21 and, in certain cases, Linkage, Lod score, Paralysis, Pediatrics and Alzheimer's disease.
His primary scientific interests are in Amyotrophic lateral sclerosis, Genetics, SOD1, Neuroscience and Gene. His Amyotrophic lateral sclerosis study incorporates themes from Mutation and Neurodegeneration. His work deals with themes such as UBQLN2 and Protein degradation, which intersect with Mutation.
Locus, Genetic linkage, Gene mapping, Genetic marker and Genetic heterogeneity are the primary areas of interest in his Genetics study. His studies deal with areas such as Chromosome and Candidate gene as well as Locus. Within one scientific family, Teepu Siddique focuses on topics pertaining to Cell biology under SOD1, and may sometimes address concerns connected to Pathogenesis.
His main research concerns Amyotrophic lateral sclerosis, Genetics, Disease, Pathology and Cell biology. His Amyotrophic lateral sclerosis research is multidisciplinary, incorporating elements of C9orf72 and Neuroscience. Many of his research projects under Genetics are closely connected to Table with Table, tying the diverse disciplines of science together.
Teepu Siddique has included themes like Psychiatry and Bioinformatics in his Disease study. The various areas that Teepu Siddique examines in his Pathology study include Dermatology, Retinal, Central nervous system, Retina and Optic nerve. His studies in Cell biology integrate themes in fields like Transfection, Pathogenesis and LRRK2.
Teepu Siddique mainly focuses on Amyotrophic lateral sclerosis, Neuroscience, C9orf72, Disease and Genetics. His research integrates issues of Neuromuscular disease and Age of onset in his study of Amyotrophic lateral sclerosis. His Neuroscience research includes elements of Mutation, Alzheimer's disease, Epigenetics and Proteasome.
His C9orf72 research is multidisciplinary, relying on both Neurodegeneration, Charged multivesicular body protein 2B, Proband and SOD1. The various areas that Teepu Siddique examines in his Disease study include Therapeutic strategy, Neurology, Intracellular and Bioinformatics. His work deals with themes such as Molecular biology and Pathogenesis, which intersect with Genetics.
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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
T. J. Kwiatkowski;D. A. Bosco;D. A. Bosco;A. L. LeClerc;A. L. LeClerc;E. Tamrazian.
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
Han Xiang Deng;Afif Hentati;John A. Tainer;Zafar Iqbal.
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng;Wenjie Chen;Seong‐Tshool Hong;Seong‐Tshool Hong;Kym M Boycott.
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
Ian R.A. Mackenzie;Eileen H. Bigio;Paul G. Ince;Felix Geser.
Annals of Neurology (2007)
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.
Yi Yang;Afif Hentati;Han Xiang Deng;Omar Dabbagh.
Nature Genetics (2001)
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.
Faisal Fecto;Jianhua Yan;S. Pavan Vemula;Erdong Liu.
JAMA Neurology (2011)
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.
Jenny S. Henkel;Joseph I. Engelhardt;László Siklós;Ericka P. Simpson.
Annals of Neurology (2004)
Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity.
T Siddique;D A Figlewicz;D A Figlewicz;M A Pericak-Vance;J L Haines.
The New England Journal of Medicine (1991)
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
Han Xiang Deng;Yong Shi;Yoshiaki Furukawa;Hong Zhai.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3
Caroline Vance;Ammar Al-Chalabi;Deborah Ruddy;Bradley N. Smith.
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