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Molecular Biology

D-Index
66
Citations
14352
World Ranking
1624
National Ranking
127

Overview

Geoffrey P. Margison is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a particular focus on molecular biology at the subfield level.

The scientist's work encompasses key topics including DNA repair mechanisms, DNA and nucleic acid chemistry, epigenetics and DNA methylation, carcinogens and genotoxicity assessment, cancer therapeutics and mechanisms, computational drug discovery methods, and cancer genomics and diagnostics.

Recent publications by Geoffrey P. Margison include the following papers:

  • QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency (2023, Pharmaceutics)
  • Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O6-Alkylguanine Adductome (2023, Chemical Research in Toxicology)
  • The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions (2023, International Journal of Molecular Sciences)
  • Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1 (2020, Nucleosides Nucleotides & Nucleic Acids)
  • Abstract 5780: Developing a screen for O6-alkylguanines in human DNA using the damage-specific binding protein, Atl1 (2020, Cancer Research)

Geoffrey P. Margison has frequently collaborated with other researchers, including:

  • David M. Williams
  • Andrew Povey
  • Pattama Senthong
  • Oliver J. Wilkinson
  • Andrew C. Povey

The scientist's work has appeared in varied publication venues, reflecting the interdisciplinary nature of their research:

  • Pharmaceutics
  • Chemical Research in Toxicology
  • International Journal of Molecular Sciences
  • Nucleosides Nucleotides & Nucleic Acids
  • Cancer Research

Best Publications

  • Mechanisms of carcinogenesis induced by alkylating agents.

    Roy Saffhill;Geoffrey P Margison;Peter J O'Connor

  • hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents

    R Brown;G L Hirst;W M Gallagher;A J McIlwrath

  • Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.

    Jennifer M. Varley;Gail McGown;Mary Thorncroft;Louise A. James

  • Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine.

    Geoffrey P. Margison;Mauro F. Santibáñez Koref;Andrew C. Povey

  • O6‐alkylguanine‐DNA alkyltransferase: Role in carcinogenesis and chemotherapy

    Geoffrey P. Margison;Mauro F. Santibáñez-Koref

  • Variability and regulation of O6-alkylguanine–DNA alkyltransferase

    Geoffrey P. Margison;Andrew C. Povey;Bernd Kaina;Mauro F. Santibáñez Koref

  • Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.

    J. C. Baer;A. A. Freeman;E. S. Newlands;A. J. Watson

  • Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine–DNA methyltransferase in hematopoietic cells

    Axel Schambach;Jens Bohne;Saurabh Chandra;Elke Will

  • Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli.

    P M Potter;M C Wilkinson;J Fitton;Francis J Carr

  • Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

    Neil J. Toft;Douglas J. Winton;Jane Kelly;Louise A. Howard

  • Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer

    Shane C White;Paul C Lorigan;Geoffrey P Margison;Jennifer M Margison

  • Lomeguatrib, a Potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors

    Malcolm R Ranson;Mark R Middleton;John Bridgewater;Siow Ming Lee

  • Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

    B Hang;B Singer;Geoffrey P Margison;Rhoderick H Elder

  • Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

    Sameer Agnihotri;Aaron S. Gajadhar;Christian Ternamian;Thierry Gorlia

  • Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy

    Bernd Kaina;Geoffrey P. Margison;Markus Christmann

  • O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy

    Barbara Verbeek;Thomas D. Southgate;David E. Gilham;Geoffrey P. Margison

  • Cloning of the E. coli O6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay

    Geoffrey P. Margison;Donald P. Cooper;John Brennand

  • Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene

    John Brennand;Geoffrey P. Margison

  • A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours

    O A Khan;M Gore;Paul C Lorigan;J Stone

  • Expression of Ku70 correlates with survival in carcinoma of the cervix.

    C R Wilson;Susan E Davidson;Geoffrey P Margison;S P Jackson

Frequent Co-Authors

Mark R. Middleton
Mark R. Middleton University of Oxford
Nick Thatcher
Nick Thatcher University of Manchester
Mauro Santibanez-Koref
Mauro Santibanez-Koref Newcastle University
Philip M. Potter
Philip M. Potter St. Jude Children's Research Hospital
Christopher Baum
Christopher Baum Charité - University Medicine Berlin
Ruggero Montesano
Ruggero Montesano International Agency For Research On Cancer
Anthony E. Pegg
Anthony E. Pegg Pennsylvania State University
David A. Williams
David A. Williams Boston Children's Hospital
Anthony Howell
Anthony Howell University of Manchester
Axel Schambach
Axel Schambach Hannover Medical School

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