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5949
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9423
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Overview

John F. Smiley is affiliated with the Nathan Kline Institute for Psychiatric Research in the United States. Their research spans several interdisciplinary fields, primarily focusing on Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. This work encompasses both broad and specialized subfields including Pediatrics, Perinatology and Child Health, Molecular Biology, Physiology, Cognitive Neuroscience, and Cellular and Molecular Neuroscience.

The scientist's research topics cover multiple core areas such as Alzheimer's disease research and treatments, prenatal substance exposure effects, retinal development and disorders, cellular transport and secretion, sleep and wakefulness research, birth, development, and health, as well as neuroscience and neuropharmacology research.

John F. Smiley has contributed to the academic community with a range of publications. Selected recent papers include:

  • Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease (2020, Cell Reports)
  • Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration (2022, Nature Communications)
  • Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission (2020, Molecular Psychiatry)
  • Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals (2021, Alcohol)
  • Reduced Motivation in Perinatal Fluoxetine-Treated Mice: A Hypodopaminergic Phenotype (2021, Journal of Neuroscience)

Frequent collaborators in their research include:

  • Cynthia Bleiwas
  • Donald A. Wilson
  • Mariko Saito
  • Shivakumar Subbanna
  • Philip Stavrides

John F. Smiley's work has been published in several respected journals, with multiple papers appearing in Frontiers in Neuroscience, Journal of Neuroscience, Cell Reports, Nature Communications, and Neuroscience & Biobehavioral Reviews.

Best Publications

  • Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain.

    Clare Bergson;Ladislav Mrzljak;John F. Smiley;Mariamma Pappy

  • D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines

    John F. Smiley;Allan I. Levey;Brian J. Ciliax;Patricia S. Goldman-Rakic

  • Somatosensory input to auditory association cortex in the macaque monkey.

    Charles E. Schroeder;Robert W. Lindsley;Colleen Specht;Alvin Marcovici

  • Auditory Cortical Neurons Respond to Somatosensory Stimulation

    Kai-Ming G. Fu;Taylor A. Johnston;Ankoor S. Shah;Lori Arnold

  • Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy

    John F. Smiley;Patricia S. Goldman-Rakic

  • The anatomy of dopamine in monkey and human prefrontal cortex.

    P. S. Goldman-Rakic;M. S. Lidow;J. F. Smiley;M. S. Williams

  • Anatomical mechanisms and functional implications of multisensory convergence in early cortical processing

    Charles E. Schroeder;John Smiley;Kaiming G. Fu;Kaiming G. Fu;Tammy McGinnis

  • Multisensory convergence in auditory cortex, I. Cortical connections of the caudal superior temporal plane in macaque monkeys.

    John F. Smiley;Troy A. Hackett;Istvan Ulbert;Istvan Ulbert;George Karmas;George Karmas

  • A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease.

    Nupur Ghoshal;John F. Smiley;Anthony J. DeMaggio;Merl F. Hoekstra

  • Light and electron microscopic characterization of dopamine-immunoreactive axons in human cerebral cortex.

    John F. Smiley;S. Mark Williams;Klara Szigeti;Patricia S. Goldman‐Rakic

  • Multisensory convergence in auditory cortex, II. Thalamocortical connections of the caudal superior temporal plane

    Troy A. Hackett;Lisa A. De La Mothe;Istvan Ulbert;George Karmos

  • Projection from Visual Areas V2 and Prostriata to Caudal Auditory Cortex in the Monkey

    Arnaud Falchier;Charles E. Schroeder;Charles E. Schroeder;Troy A. Hackett;Peter Lakatos

  • Monoaminergic–cholinergic interactions in the primate basal forebrain

    J. F. Smiley;M. Subramanian;Marek-Marsel Mesulam

  • Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

    Ying Jiang;Ying Jiang;Andrew Rigoglioso;Corrinne M. Peterhoff;Monika Pawlik

  • Timing and laminar profile of eye-position effects on auditory responses in primate auditory cortex.

    Kai-Ming G. Fu;Ankoor S. Shah;Monica N. O'Connell;Tammy McGinnis

  • Microarray Analysis of Gene Expression in Rat Hippocampus After Chronic Ethanol Treatment

    Mariko Saito;John Smiley;Reka Toth;Csaba Vadasz

  • Cholinergic Synapses in Human Cerebral Cortex: An Ultrastructural Study in Serial Sections

    John F. Smiley;Frank Morrell;Marek Marsel Mesulam

  • Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.

    Anna Pensalfini;Anna Pensalfini;Seonil Kim;Seonil Kim;Shivakumar Subbanna;Cynthia Bleiwas

  • Multisensory connections of monkey auditory cerebral cortex

    John F. Smiley;Arnaud Falchier

  • Sources of somatosensory input to the caudal belt areas of auditory cortex.

    Troy A Hackett;John F Smiley;Istvan Ulbert;George Karmos

  • Continuous Phencyclidine Treatment Induces Schizophrenia-Like Hyperreactivity of Striatal Dopamine Release

    Andrea Balla;Rajeth Koneru;John Smiley;Henry Sershen;Henry Sershen

Frequent Co-Authors

Daniel C. Javitt
Daniel C. Javitt Columbia University
Charles E. Schroeder
Charles E. Schroeder Nathan Kline Institute for Psychiatric Research
Donald A. Wilson
Donald A. Wilson Nathan Kline Institute for Psychiatric Research
Peter Lakatos
Peter Lakatos Nathan Kline Institute for Psychiatric Research
Troy A. Hackett
Troy A. Hackett Vanderbilt University Medical Center
Gorazd Rosoklija
Gorazd Rosoklija Columbia University
Ralph A. Nixon
Ralph A. Nixon Nathan Kline Institute for Psychiatric Research
István Ulbert
István Ulbert Pázmány Péter Catholic University
Henry Sershen
Henry Sershen New York University
Balapal S. Basavarajappa
Balapal S. Basavarajappa Nathan Kline Institute for Psychiatric Research

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