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Neuroscience

D-Index
54
Citations
9379
World Ranking
4961
National Ranking
286

Overview

Andis Klegeris is affiliated with the University of British Columbia in Canada and has contributed extensively to research focused on neuroscience, immunology, and medicine. Their scholarly output covers a broad range of topics including neuroinflammation, neurodegeneration mechanisms, and immune response in the context of brain disorders.

Their research portfolio includes recent publications such as:

  • Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells, 2020, Molecular and Cellular Neuroscience
  • Glia-Driven Neuroinflammation and Systemic Inflammation in Alzheimer's Disease, 2020, Current Neuropharmacology
  • Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis, 2022, Frontiers in Immunology
  • Potential neurotoxic activity of diverse molecules released by microglia, 2021, Neurochemistry International
  • Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns, 2020, Neural Regeneration Research

Klegeris's work has been featured frequently in these publication venues:

  • Molecular and Cellular Neuroscience
  • Neural Regeneration Research
  • Reviews in the Neurosciences
  • Frontiers in Immunology
  • Molecules

Their research spans several main fields of study:

  • Neuroscience
  • Immunology and Microbiology
  • Medicine

Subfields within their work include:

  • Neurology
  • Immunology
  • Physiology
  • Molecular Biology
  • Biological Psychiatry

Klegeris has explored several core topics in their research:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Immune Response and Inflammation
  • Immune cells in cancer
  • Tryptophan and brain disorders
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Fatty Acid Research and Health

They collaborate regularly with several frequent co-authors including Tyler J. Wenzel, Taryn E. Murray, Julien Gibon, Christy M. Richards, and Seamus A. McRae.

Best Publications

  • Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid‐type CB2 receptor

    Andis Klegeris;Christopher J Bissonnette;Patrick L McGeer

  • α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

    Andis Klegeris;Steven Pelech;Benoit I. Giasson;John Maguire

  • Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells.

    Tyler J. Wenzel;Ellen J. Gates;Athena L. Ranger;Andis Klegeris

  • Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases.

    Lindsay Joy Spielman;Deanna Lynn Gibson;Andis Klegeris

  • Impact of problem-based learning in a large classroom setting: student perception and problem-solving skills.

    Andis Klegeris;Heather Hurren

  • Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide

    Sadayuki Hashioka;Andis Klegeris;Akira Monji;Takahiro Kato

  • Therapeutic approaches to inflammation in neurodegenerative disease.

    Andis Klegeris;Edith G McGeer;Patrick L McGeer

  • Activation of Macrophages by Alzheimer β Amyloid Peptide

    A. Klegeris;D.G. Walker;P.L. Mcgeer

  • LRRK2 Expression in Normal and Pathologic Human Brain and in Human Cell Lines

    Judith Miklossy;Tetsuaki Arai;Jian-Ping Guo;Andis Klegeris

  • Inflammation, the complement system and the diseases of aging

    Edith G. McGeer;Andis Klegeris;Patrick L. McGeer

  • Thrombin and Prothrombin Are Expressed by Neurons and Glial Cells and Accumulate in Neurofibrillary Tangles in Alzheimer Disease Brain

    Tetsuaki Arai;Judith Miklossy;Andis Klegeris;Jian-Ping Guo

  • Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

    Lindsay J. Spielman;Jonathan P. Little;Andis Klegeris

  • Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

    Gunnar R Leitner;Tyler J Wenzel;Nick Marshall;Ellen J Gates

  • beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate.

    Andis Klegeris;Patrick L. McGeer

  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Other Anti- Inflammatory Agents in the Treatment of Neurodegenerative Disease

    Andis Klegeris;Patrick L McGeer

  • Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells

    Andis Klegeris;Benoit I. Giasson;Hong Zhang;John Maguire

  • Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α

    Andis Klegeris;Douglas G Walker;Patrick L McGeer

  • Physical activity and exercise attenuate neuroinflammation in neurological diseases.

    Lindsay Joy Spielman;Jonathan Peter Little;Andis Klegeris

  • Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity

    Andis Klegeris;Patrick L McGeer

  • Inflammation in transgenic mouse models of neurodegenerative disorders.

    Claudia Schwab;Andis Klegeris;Patrick. L. McGeer

  • Autoxidation of dopamine: a comparison of luminescent and spectrophotometric detection in basic solutions.

    Andis Klegeris;Ljudmila G. Korkina;Susan A. Greenfield

  • Interferon-γ-dependent cytotoxic activation of human astrocytes and astrocytoma cells

    Sadayuki Hashioka;Andis Klegeris;Claudia Schwab;Patrick L. McGeer

Frequent Co-Authors

Edith G. McGeer
Edith G. McGeer University of British Columbia
Douglas G. Walker
Douglas G. Walker Arizona State University
James G. McLarnon
James G. McLarnon University of British Columbia
Bruce A. Vallance
Bruce A. Vallance University of British Columbia
Steven F. Maier
Steven F. Maier University of Colorado Boulder

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