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Pierre-Yves Renard

Pierre-Yves Renard

Centre national de la recherche scientifique, CNRS
France

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Enzyme
  • Catalysis

His scientific interests lie mostly in Combinatorial chemistry, Acetylcholinesterase, Linker, Nerve agent and Stereochemistry. His Combinatorial chemistry research is multidisciplinary, relying on both BODIPY, Catalysis, Monoclonal antibody, Peptide and Solubility. Acetylcholinesterase is the subject of his research, which falls under Enzyme.

Protease, Organic chemistry and Biochemistry are fields of study that intersect with his Linker study. His research in Nerve agent intersects with topics in Hydrolysis, Aché, Pharmacology and Reactivity. Pierre-Yves Renard studies Moiety which is a part of Stereochemistry.

His most cited work include:

  • Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents (208 citations)
  • Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. (185 citations)
  • Water-Soluble BODIPY Derivatives (139 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Organic chemistry, Combinatorial chemistry, Acetylcholinesterase, Stereochemistry and Moiety. Pierre-Yves Renard merges Organic chemistry with Linker in his research. His study in Combinatorial chemistry is interdisciplinary in nature, drawing from both Reactivity, Molecule, Nucleophile and Peptide.

His Acetylcholinesterase study is focused on Enzyme in general. Pierre-Yves Renard works mostly in the field of Stereochemistry, limiting it down to concerns involving Monoclonal antibody and, occasionally, Immunoassay. His research integrates issues of Ketone, Quinoline and Biochip in his study of Moiety.

He most often published in these fields:

  • Organic chemistry (60.00%)
  • Combinatorial chemistry (47.14%)
  • Acetylcholinesterase (28.93%)

What were the highlights of his more recent work (between 2016-2021)?

  • Acetylcholinesterase (28.93%)
  • Pharmacology (10.36%)
  • Nerve agent (22.50%)

In recent papers he was focusing on the following fields of study:

Pierre-Yves Renard mainly investigates Acetylcholinesterase, Pharmacology, Nerve agent, Combinatorial chemistry and Stereochemistry. His studies in Acetylcholinesterase integrate themes in fields like Nicotinic Receptors and Active site. His Nerve agent research focuses on subjects like Oxime, which are linked to Paraoxon.

Pierre-Yves Renard studies Combinatorial chemistry, focusing on Bioconjugation in particular. His Stereochemistry research incorporates themes from Pyridinium, Structure–activity relationship and Phosphorylation. In his study, which falls under the umbrella issue of Covalent bond, Moiety is strongly linked to Substituent.

Between 2016 and 2021, his most popular works were:

  • Azo-Based Fluorogenic Probes for Biosensing and Bioimaging: Recent Advances and Upcoming Challenges. (40 citations)
  • Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies (35 citations)
  • Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration. (27 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Enzyme
  • Catalysis

Acetylcholinesterase, Stereochemistry, Oxime, Aché and Pharmacology are his primary areas of study. His Acetylcholinesterase study is concerned with the field of Enzyme as a whole. His work is dedicated to discovering how Enzyme, In vitro are connected with Pharmacophore and other disciplines.

His Stereochemistry research is multidisciplinary, incorporating perspectives in Bifunctional, Lectin and Isothiocyanate. His Oxime study incorporates themes from Morpholine and Paraoxon. His research investigates the connection between Aché and topics such as Drug that intersect with problems in Zeta potential.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Julien Renou;Julien Renou;Maria Kliachyna.
Accounts of Chemical Research (2012)

316 Citations

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

Florian Nachon;Eugénie Carletti;Cyril Ronco;Marie Trovaslet.
Biochemical Journal (2013)

294 Citations

Water-Soluble BODIPY Derivatives

Song Lin Niu;Gilles Ulrich;Raymond Ziessel;Agneta Kiss.
Organic Letters (2009)

242 Citations

Design and synthesis of chemiluminescent probes for the detection of cholinesterase activity.

Stéphane Sabelle;Pierre-Yves Renard;Karine Pecorella;Sophie de Suzzoni-Dézard.
Journal of the American Chemical Society (2002)

179 Citations

High-throughput screening of enantioselective catalysts by immunoassay.

Frédéric Taran;Cécile Gauchet;Barbara Mohar;Stéphane Meunier.
Angewandte Chemie (2002)

167 Citations

Novel water-soluble near-infrared cyanine dyes: synthesis, spectral properties, and use in the preparation of internally quenched fluorescent probes.

Cédric Bouteiller;Guillaume Clavé;Aude Bernardin;Bertrand Chipon.
Bioconjugate Chemistry (2007)

137 Citations

Water‐Soluble Red‐Emitting Distyryl‐Borondipyrromethene (BODIPY) Dyes for Biolabeling

Song-lin Niu;Cédrik Massif;Gilles Ulrich;Pierre-Yves Renard;Pierre-Yves Renard;Pierre-Yves Renard.
Chemistry: A European Journal (2012)

118 Citations

7-Hydroxycoumarin−Hemicyanine Hybrids: A New Class of Far-Red Emitting Fluorogenic Dyes

Jean-Alexandre Richard;Marc Massonneau;Pierre-Yves Renard;Anthony Romieu.
Organic Letters (2008)

117 Citations

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

Guillaume Mercey;Guillaume Mercey;Tristan Verdelet;Tristan Verdelet;Géraldine Saint-André;Emilie Gillon.
Chemical Communications (2011)

114 Citations

Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?

Constantinos Pantos;Iordanis Mourouzis;Theodosios Saranteas;Guillaume Clavé.
Basic Research in Cardiology (2009)

108 Citations

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