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Neuroscience

D-Index
52
Citations
8092
World Ranking
5392
National Ranking
457

Overview

Carsten Saft is affiliated with Ruhr University Bochum in Germany and focuses on research primarily in the fields of medicine, neuroscience, and biochemistry, genetics, and molecular biology. Their work concentrates on neurology and cellular and molecular neuroscience, with significant contributions in molecular biology as well. The scientist's research spans multiple subfields including endocrinology, diabetes and metabolism, and epidemiology.

The main topics covered by Saft's research include genetic neurodegenerative diseases, neurological disorders and treatments, mitochondrial function and pathology, and botulinum toxin and related neurological disorders. Additional areas of study include Parkinson's disease mechanisms and treatments, neurological and metabolic disorders, and ubiquitin and proteasome pathways.

Saft has published articles in various journals, with frequent contributions in the following venues:

  • Brain Sciences
  • Brain and Behavior
  • The Lancet Neurology
  • Neurological Research and Practice
  • Journal of Huntington s Disease

Recent papers authored or co-authored by Saft include:

  • "Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1," 2020, Human Molecular Genetics
  • "NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62," 2023, Nature Communications
  • "Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study," 2024, The Lancet Neurology
  • "Association of CAG Repeat Length in the Huntington Gene With Cognitive Performance in Young Adults," 2021, Neurology
  • "Symptomatic treatment options for Huntington's disease (guidelines of the German Neurological Society)," 2023, Neurological Research and Practice

Saft collaborates frequently with several researchers, including Jannis Achenbach, Sarah Hein, Huu Phuc Nguyen, Ralf Reilmann, and Klaus Seppi.

Best Publications

  • Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

    Davina J Hensman Moss;Antonio F Pardiñas;Douglas Langbehn;Kitty Lo

  • Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study

    J Kassubek;F D Juengling;T Kioschies;K Henkel

  • Response inhibition subprocesses and dopaminergic pathways: Basal ganglia disease effects

    Christian Beste;Rita Willemssen;Carsten Saft;Michael Falkenstein

  • Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease.

    Carsten Saft;Jochen Zange;Jiirgen Andrich;Klaus Müller

  • Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease

    Gisa Ellrichmann;Elisabeth Petrasch-Parwez;De-Hyung Lee;Christiane Reick

  • Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial

    Justo Garcia de Yebenes;Bernhard Landwehrmeyer;Ferdinando Squitieri;Ralf Reilmann

  • The Role of the Immune System in Huntington’s Disease

    Gisa Ellrichmann;Christiane Reick;Carsten Saft;Ralf A. Linker

  • Treating the whole body in Huntington's disease

    Jeffrey B Carroll;Gillian P Bates;Joan Steffan;Carsten Saft

  • An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

    Sigurd D. Süssmuth;Salman Haider;G. Bernhard Landwehrmeyer;Ruth Farmer

  • PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

    Elahe Taherzadeh-Fard;Carsten Saft;Denis A Akkad;Stefan Wieczorek

  • NR2A and NR2B receptor gene variations modify age at onset in Huntington disease.

    Larissa Arning;Peter H. Kraus;Sandra Valentin;Carsten Saft

  • PGC-1alpha as modifier of onset age in Huntington disease

    Elahe Taherzadeh-Fard;Carsten Saft;Jürgen Andrich;Stefan Wieczorek

  • Autonomic nervous system function in Huntington's disease

    J Andrich;T Schmitz;C Saft;T Postert

  • Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation.

    Ferdinando Squitieri;Milena Cannella;Gianluca Sgarbi;Vittorio Maglione

  • Response inhibition in Huntington's disease-a study using ERPs and sLORETA.

    Christian Beste;Carsten Saft;Jürgen Andrich;Ralf Gold

  • Patterns of CAG repeat instability in the central nervous system and periphery in Huntington’s disease and in spinocerebellar ataxia type 1

    Ricardo Mouro Pinto;Larissa Arning;James V. Giordano;Pedram Razghandi

  • Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study.

    Ralf Reilmann;Ralf Reilmann;Andrew McGarry;Igor D Grachev;Juha-Matti Savola

  • A randomized, placebo‐controlled trial of AFQ056 for the treatment of chorea in Huntington's disease

    Ralf Reilmann;Marie-Laure Rouzade-Dominguez;Carsten Saft;Sigurd D. Süssmuth

  • Error processing in normal aging and in basal ganglia disorders.

    C. Beste;R. Willemssen;C. Saft;M. Falkenstein

  • On the role of fronto-striatal neural synchronization processes for response inhibition—Evidence from ERP phase-synchronization analyses in pre-manifest Huntington's disease gene mutation carriers

    Christian Beste;Vanessa Ness;Michael Falkenstein;Carsten Saft

  • Mechanisms mediating parallel action monitoring in fronto-striatal circuits.

    Christian Beste;Vanessa Ness;Carsten Lukas;Rainer Hoffmann

  • Time processing in Huntington's disease: a group-control study.

    Christian Beste;Christian Beste;Christian Beste;Carsten Saft;Jürgen Andrich;Thomas Müller

  • Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis

    Michael Föller;Andreas Hermann;Shuchen Gu;Ioana Alesutan

  • Stimulus-Response Compatibility in Huntington's Disease: A Cognitive-Neurophysiological Analysis

    Christian Beste;Carsten Saft;Jiirgen Andrich;Ralf Gold

Frequent Co-Authors

Jörg T. Epplen
Jörg T. Epplen Ruhr University Bochum
Michael Orth
Michael Orth University of Ulm
Horst Przuntek
Horst Przuntek Ruhr University Bochum
Michael Falkenstein
Michael Falkenstein TU Dortmund University
Anne Elizabeth Rosser
Anne Elizabeth Rosser Cardiff University
Robert Christian Wolf
Robert Christian Wolf Heidelberg University
Ludger Schöls
Ludger Schöls University of Tübingen
Anna Rita Bentivoglio
Anna Rita Bentivoglio Catholic University of the Sacred Heart
Martin Brüne
Martin Brüne Ruhr University Bochum

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