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Neuroscience

D-Index
57
Citations
19887
World Ranking
4265
National Ranking
125

Overview

Keiji Imoto is affiliated with the National Institute for Physiological Sciences in Japan. Their research spans multiple fields within medicine, with a strong focus on molecular biology, surgery, cardiology and cardiovascular medicine, cellular and molecular neuroscience, and physiology.

Their primary areas of study include ion channel regulation and function, cardiac electrophysiology and arrhythmias, neuroscience and neuropharmacology research, pain mechanisms and treatments, anesthesia and pain management, and botulinum toxin and related neurological disorders. They have published extensively on these topics, contributing to a varied range of scientific disciplines.

Recent papers by Keiji Imoto include the following:

  • L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons (2020, Anesthesiology)
  • A computational analysis of the effect of sevoflurane in a human ventricular cell model of long QT syndrome: Importance of repolarization reserve in the QT-prolonging effect of sevoflurane (2020, European Journal of Pharmacology)
  • Novel KCNQ1 Q234K variant, identified in patients with long QT syndrome and epileptiform activity, induces both gain- and loss-of-function of slowly activating delayed rectifier potassium currents (2024, Frontiers in Physiology)
  • Hippocampus-related cognitive disorders develop in the absence of epilepsy and ataxia in the heterozygous Cacna1a mutant mice tottering (2022, Channels)
  • Clinical efficacy of neck stabilizer for cervical spine injury (2025, Scientific Reports)

Frequent coauthors in Keiji Imoto's body of work include:

  • Hideki Itoh
  • Daisuke Uta
  • Kohei Koga
  • Hidemasa Furue
  • Megumu Yoshimura

Regular venues for their publications encompass:

  • Anesthesiology
  • Frontiers in Physiology
  • European Journal of Pharmacology
  • Channels
  • Scientific Reports

The multidisciplinary nature of Keiji Imoto's work reflects an intersection of biochemistry, genetics, molecular biology, neuroscience, and clinical medicine. Their research advances understanding of ion channel functionality and cardiac electrophysiology, relevant to both fundamental biological processes and clinical interventions.

Best Publications

  • A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein.

    Junichi Nakai;Masamichi Ohkura;Keiji Imoto

  • Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

    Atsushi Mikami;Keiji Imoto;Tsutomu Tanabe;Tetsuhiro Niidome

  • Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

    Masayoshi Mishina;Toshiyuki Takai;Keiji Imoto;Masaharu Noda

  • PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY DNA OF A BRAIN CALCIUM CHANNEL

    Yasuo Mori;Thomas Friedrich;Man Suk Kim;Atsushi Mikami

  • LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

    Yuji Hara;Minoru Wakamori;Masakazu Ishii;Emi Maeno;Emi Maeno

  • Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance.

    Keiji Imoto;Christopher Busch;Bert Sakmann;Masayoshi Mishina

  • Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons

    Fritjof Helmchen;K. Imoto;Bert Sakmann

  • Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7 Ca2+-PERMEABLE CATION CHANNEL THAT IS CONSTITUTIVELY ACTIVATED AND ENHANCED BY STIMULATION OF G PROTEIN-COUPLED RECEPTOR

    Takaharu Okada;Ryuji Inoue;Kazuto Yamazaki;Akito Maeda

  • Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain.

    Yasuhiro Hakamata;Junichi Nakai;Hiroshi Takeshima;Keiji Imoto

  • Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2

    Yvonne M. Tallini;Masamichi Ohkura;Bum Rak Choi;Guangju Ji

  • A missense mutation of the Na+ channel αII subunit gene Nav1.2 in a patient with febrile and afebrile seizures causes channel dysfunction

    Takashi Sugawara;Yuji Tsurubuchi;Kishan Lal Agarwala;Masatoshi Ito

  • Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

    Masayoshi Mishina;Takamasa Tobimatsu;Keiji Imoto;Ken Ichi Tanaka

  • Location of a δ-Subunit Region Determining Ion Transport Through the Acetylcholine Receptor Channel

    Keiji Imoto;Keiji Imoto;Christoph Methfessel;Bert Sakmann;Masayoshi Mishina

  • Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

    Takaharu Okada;Shunichi Shimizu;Minoru Wakamori;Akito Maeda

  • Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

    Tetsuya Shiuchi;Mohammad Shahidul Haque;Shiki Okamoto;Tsuyoshi Inoue

  • Single Tottering Mutations Responsible for the Neuropathic Phenotype of the P-type Calcium Channel

    Minoru Wakamori;Kazuto Yamazaki;Hiroshi Matsunodaira;Tetsuyuki Teramoto

  • A-Type K+ Current Mediated by the Kv4 Channel Regulates the Generation of Action Potential in Developing Cerebellar Granule Cells

    Riichi Shibata;Kensuke Nakahira;Koji Shibasaki;Yoshihiko Wakazono

  • Differential nociceptive responses in mice lacking the α1B subunit of N-type Ca2+ channels

    Shinji Hatakeyama;Minoru Wakamori;Mitsuhiro Ino;Norimasa Miyamoto

  • Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs.

    Shigeru Yokoyama;Shigeru Yokoyama;Keiji Imoto;Tetsuro Kawamura;Haruhiro Higashida

  • Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))

    Yasuo Mori;Minoru Wakamori;Sen Ichi Oda;Colin F. Fletcher

Frequent Co-Authors

Hidemasa Furue
Hidemasa Furue Hyogo College of Medicine
Megumu Yoshimura
Megumu Yoshimura Kumamoto Health Science University
Yuchio Yanagawa
Yuchio Yanagawa Gunma University
Masahiko Watanabe
Masahiko Watanabe Hokkaido University
Kunihiko Obata
Kunihiko Obata The Graduate University for Advanced Studies, SOKENDAI
Ryuichi Shigemoto
Ryuichi Shigemoto Institute of Science and Technology Austria
Mami Noda
Mami Noda Kyushu University
Anthony E. Pickering
Anthony E. Pickering University of Bristol
Hiroyuki Sakagami
Hiroyuki Sakagami Kitasato University
Jun Kudoh
Jun Kudoh Keio University

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