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Raymond J. Pierce

Raymond J. Pierce

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
10758
World Ranking
12712
National Ranking
475

Overview

Raymond J. Pierce is affiliated with the University of Lille in France. Their research primarily focuses on molecular biology and parasitology, with significant contributions to the fields of biochemistry, genetics, molecular biology, and medicine. The subfields of study include molecular biology, parasitology, epidemiology, public health, environmental and occupational health, and pharmacology.

The main topics of their work cover a range of biomedical and parasitological subjects such as histone deacetylase inhibitors research, parasites and host interactions, Trypanosoma species research and implications, research on leishmaniasis studies, cancer-related gene regulation, cholinesterase and neurodegenerative diseases, and signaling pathways in disease.

Raymond J. Pierce has coauthored multiple publications with several frequent collaborators. Notable frequent coauthors include Wolfgang Sippl, Julien Lancelot, Tino Heimburg, Marina de Moraes Mourão, and Ehab Ghazy.

Their recent papers highlight research on inhibitors targeting epigenetic regulators and their effects on parasitic diseases. Selected recent publications include:

  • "Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis" (2022) published in Pharmaceuticals
  • "Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni" (2020) published in PLoS neglected tropical diseases
  • "Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2" (2021) published in Cell Reports
  • "Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis" (2021) published in European Journal of Medicinal Chemistry
  • "Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis" (2020) published in Biochemical Pharmacology

Their work has been published frequently in several scientific venues, with multiple publications appearing in PLoS neglected tropical diseases and Frontiers in Microbiology, along with contributions to the European Journal of Medicinal Chemistry, Pharmaceuticals, and Cell Reports.

Best Publications

  • The genome of the blood fluke Schistosoma mansoni

    Matthew Berriman;Brian J. Haas;Brian J. Haas;Philip T. LoVerde;R. Alan Wilson

  • Ligand binding was acquired during evolution of nuclear receptors

    Hector Escriva;Rachid Safi;Catherine Hänni;Marie-Claire Langlois

  • Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection

    D. W. Dunne;A. E. Butterworth;A. J. C. Fulford;H. C. Kariuki

  • Molecular Phylogenies of Blastocystis Isolates from Different Hosts: Implications for Genetic Diversity Identification of Species and Zoonosis

    Christophe Noël;Fabienne Dufernez;Delphine Gerbod;Virginia P. Edgcomb

  • Molecular cloning of a protective antigen of schistosomes

    J M Balloul;P Sondermeyer;D Dreyer;M Capron

  • Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii.

    M F Cesbron-Delauw;B Guy;G Torpier;R J Pierce

  • Role of IgE receptors in effector function of human eosinophils.

    M Capron;H L Spiegelberg;L Prin;H Bennich

  • HDAC8: a multifaceted target for therapeutic interventions

    Alokta Chakrabarti;Ina Oehme;Olaf Witt;Guilherme Oliveira

  • A purified 28,000 dalton protein from Schistosoma mansoni adult worms protects rats and mice against experimental schistosomiasis.

    J M Balloul;J M Grzych;R J Pierce;A Capron

  • Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoni.

    D. Boulanger;G.D.F. Reid;R.F. Sturrock;I. Wolowczuk

  • Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.

    Martin Marek;Srinivasaraghavan Kannan;Alexander-Thomas Hauser;Marina de Moraes Mourão

  • Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

    Tino Heimburg;Alokta Chakrabarti;Julien Lancelot;Martin Marek

  • Inter-species variation of schistosome 28-kDa glutathione S-transferases.

    François Trottein;Claude Godin;Raymond J. Pierce;Bertrand Sellin

  • Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

    Florence Dubois;Stéphanie Caby;Stéphanie Caby;Stéphanie Caby;Frédérik Oger;Céline Cosseau

  • Serodiagnosis of toxoplasma infection using a purified parasite protein (P30).

    F Santoro;D Afchain;R Pierce;J Y Cesbron

  • Cytosolic location of an endo-N-acetyl-beta-D-glucosaminidase activity in rat liver and kidney.

    R J Pierce;G Spik;J Montreuil

  • Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni.

    Alvaro Baeza Garcia;Raymond J. Pierce;Benjamin Gourbal;Elisabeth Werkmeister

  • Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella.

    C M Khan;B Villarreal-Ramos;R J Pierce;G Riveau

  • Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

    Julien Lancelot;Stéphanie Caby;Florence Dubois-Abdesselem;Mathieu Vanderstraete

  • Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

    Ming Jang Chua;Megan S J Arnold;Weijun Xu;Julien Lancelot

Frequent Co-Authors

André Capron
André Capron Institut Pasteur
Monique Capron
Monique Capron University of Lille
Wolfgang Sippl
Wolfgang Sippl Martin Luther University Halle-Wittenberg
Manfred Jung
Manfred Jung University of Freiburg
Eric Viscogliosi
Eric Viscogliosi Institut Pasteur
Sergio Verjovski-Almeida
Sergio Verjovski-Almeida Universidade de São Paulo
Marie-France Cesbron-Delauw
Marie-France Cesbron-Delauw Grenoble Alpes University
François Trottein
François Trottein Institut Pasteur
Guillaume Mitta
Guillaume Mitta University of Montpellier
Vincent Laudet
Vincent Laudet Okinawa Institute of Science and Technology

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