Richard M. Philpot

Overview

Best Publications

• Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3

  Dieter H. Lang;Catherine K. Yeung;Raimund M. Peter;Catherine Ibarra

  328
  Citations

• A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.

  M.P. Lawton;J.R. Cashman;T. Cresteil;C.T. Dolphin

  266
  Citations

• Cytochrome p-450: localization in rabbit lung.

  Cosette J. Serabjit-Singh;C. Roland Wolf;Richard M. Philpot;Charles G. Plopper

  254
  Citations

• Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters.

  A. Buckpitt;Ai-Min Chang;A. Weir;L. Van Winkle

  227
  Citations

• Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans

  Lila H Overby;Geraldine C Carver;Richard M Philpot

  203
  Citations

• The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components.

  C J Serabjit-Singh;C R Wolf;R M Philpot

  165
  Citations

• The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression

  R.N. Hines;J.R. Cashman;R.M. Philpot;D.E. Williams

  158
  Citations

• Cytochrome P-450 mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in Saccharomyces cerevisiae.

  David F. Callen;C.Roland Wolf;Richard M. Philpot

  154
  Citations

• Identification of Cytochrome P-450 Isozymes in Nonciliated Bronchiolar Epithelial (Clara) and Alveolar Type II Cells Isolated from Rabbit Lung

  Theodora R. Devereux;Cosette J. Serabjit-singh;Shelley R. Slaughter;C. Roland Wolf

  138
  Citations

• The Pulmonary Uptake, Accumulation, and Metabolism of Xenobiotics

  J R Bend;C J Serabjit-Singh;R M Philpot

  137
  Citations

• The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.

  D C Zeldin;J D Plitman;J Kobayashi;R F Miller

  135
  Citations

• Metabolism of Carbon Tetrachloride in Hepatic Microsomes and Reconstituted Monooxygenase Systems and Its Relationship to Lipid Peroxidation

  Wolf Cr;Harrelson Wg;Nastainczyk Wm;Philpot Rm

  135
  Citations

• The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes.

  M P Lawton;R Gasser;R E Tynes;E Hodgson

  134
  Citations

• The production and modification of cytochrome P-450 difference spectra by in vivo administration of methylenedioxyphenyl compounds

  R.M. Philpot;E. Hodgson

  132
  Citations

• The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: an ultrastructural immunocytochemical characterization.

  C. J. Serabjit-Singh;S. J. Nishio;R. M. Philpot;Charles Plopper

  128
  Citations

• Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.

  Maciej Czerwinski;Theodore L. McLemore;Richard M. Philpot;Patson T. Nhamburo

  117
  Citations

• CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid.

  Allan E. Rettie;Pamela R. Sheffels;Kenneth R. Korzekwa;Frank J. Gonzalez

  115
  Citations

• Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog.

  L. H. Overby;Alan R Buckpitt;M. P. Lawton;E. Attaasafoadjei

  113
  Citations

• Quantitation of rabbit cytochrome P-450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxidase-immunostaining procedure

  Barbara A. Domin;Cosette J. Serabjit-Singh;Richard M. Philpot

  111
  Citations

• The cytochrome P-450 monooxygenase system of rabbit lung enzyme components, activities, and induction in the nonciliated bronchiolar epithelial (Clara) cell, alveolar type II cell, and alveolar macrophage.

  B A Domin;T R Devereux;R M Philpot

  102
  Citations