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Biology and Biochemistry

D-Index
45
Citations
6820
World Ranking
19147
National Ranking
1488

Overview

Elizabeth A. Shephard is affiliated with University College London in the United Kingdom. Their research spans multiple fields, primarily within Medicine and Biochemistry, Genetics and Molecular Biology. The scientist's work engages with several subfields including Physiology, Molecular Biology, Pediatrics, Perinatology and Child Health, Pathology and Forensic Medicine, and Cancer Research.

The research focus covers a range of topics reflecting complex biological and metabolic processes. Key areas include:

  • Metabolomics and Mass Spectrometry Studies
  • Adipose Tissue and Metabolism
  • Alcohol Consumption and Health Effects
  • Cancer, Hypoxia, and Metabolism
  • Aldose Reductase and Taurine
  • Cassava research and cyanide
  • Diet and metabolism studies

Their publication record includes collaborative work with frequent coauthors such as Ian Phillips, Sunil Veeravalli, Daniel Fatori, Guilherme V. Polanczyk, and Dorsa Varshavi. These collaborative efforts have appeared in various journals, with multiple articles published in bioRxiv (Cold Spring Harbor Laboratory), along with contributions to Drug Metabolism and Disposition, Frontiers in Physiology, PLoS ONE, and BMC Public Health.

Recent and notable papers by Elizabeth A. Shephard include:

  • "Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine" (2020) published in Drug Metabolism and Disposition
  • "Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition" (2022) published in Frontiers in Physiology
  • "Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism" (2023) published in PLoS ONE
  • "Living with trimethylaminuria and body and breath malodour: personal perspectives" (2024) published in BMC Public Health
  • "Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study" (2025) published in Development and Psychopathology

Best Publications

  • Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome

    C T Dolphin;A Janmohamed;R L Smith;E A Shephard

  • Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease

    Diede Fennema;Ian R. Phillips;Elizabeth A. Shephard

  • A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

    Anthony C. Dona;Michael Kyriakides;Flora Scott;Elizabeth A. Shephard

  • A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.

    M.P. Lawton;J.R. Cashman;T. Cresteil;C.T. Dolphin

  • Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.

    C T Dolphin;T E Cullingford;E A Shephard;R L Smith

  • Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.

    Diana Hernandez;Azara Janmohamed;Pritpal Chandan;Ian R Phillips

  • The molecular biology of the flavin-containing monooxygenases of man.

    Ian R. Phillips;Colin T. Dolphin;Philippe Clair;Mark R. Hadley

  • The Flavin-containing Monooxygenase 2 Gene (FMO2) of Humans, but Not of Other Primates, Encodes a Truncated, Nonfunctional Protein

    Colin T. Dolphin;Daniel J. Beckett;Azara Janmohamed;Timothy E. Cullingford

  • Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450.

    Azara Janmohamed;Colin T Dolphin;Ian R Phillips;Elizabeth A Shephard

  • Flavin-containing monooxygenases: mutations, disease and drug response.

    Ian R. Phillips;Elizabeth A. Shephard

  • Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics.

    Despina Smirlis;Roongsiri Muangmoonchai;Mina Edwards;Ian R. Phillips

  • The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids.

    CA CaJacob;WK Chan;EA Shephard;PR Ortiz de Montellano

  • Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos)

    Azara Janmohamed;Diana Hernandez;Ian R Phillips;Elizabeth A Shephard

  • Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1.

    Roongsiri Muangmoonchai;Despina Smirlis;Siew-Cheng Wong;Mina Edwards

  • Cytochrome P450 protocols

    Ian R. Phillips;Elizabeth A. Shephard

  • Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).

    C. Dolphin;E. A. Shephard;S. Povey;C. N. A. Palmer

  • Trimethylaminuria and a human FMO3 mutation database.

    Diana Hernandez;Sarah Addou;David Lee;Christine Orengo

  • Drug metabolism by flavin-containing monooxygenases of human and mouse

    Ian R Phillips;Elizabeth A Shephard

  • Ethnic Differences in Human Flavin-Containing Monooxygenase 2 (FMO2) Polymorphisms: Detection of Expressed Protein in African-Americans

    J.R Whetstine;M.-F Yueh;K.A Hopp;D.G McCarver

  • A methodology for global-sensitivity analysis of time-dependent outputs in systems biology modelling.

    T. Sumner;E. Shephard;I. D. L. Bogle

Frequent Co-Authors

Ian Phillips
Ian Phillips University College London
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Janet L. Stein
Janet L. Stein University of Vermont
Gary S. Stein
Gary S. Stein University of Vermont
Robert L. Smith
Robert L. Smith Imperial College London
Colin N. A. Palmer
Colin N. A. Palmer University of Dundee
David E. Williams
David E. Williams Oregon State University
Alexander C. Lichtler
Alexander C. Lichtler University of Connecticut Health Center
Ronald N. Hines
Ronald N. Hines Yale University
Maurizio Genuardi
Maurizio Genuardi Catholic University of the Sacred Heart

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