Charles Nicholson mainly investigates Extracellular, Biophysics, Neuroscience, Tortuosity and Volume fraction. He interconnects Neocortex, Ionic bonding and Cortical spreading depression in the investigation of issues within Extracellular. The Biophysics study combines topics in areas such as Cerebellum, Iontophoresis and Diffusion equation.
While the research belongs to areas of Neuroscience, Charles Nicholson spends his time largely on the problem of Brain tissue, intersecting his research to questions surrounding Volume, Rat brain and Sprague dawley. His Tortuosity study spans across into subjects like Tetramethylammonium and Membrane. Charles Nicholson combines subjects such as Measure and Nanotechnology with his study of Volume fraction.
His primary areas of study are Biophysics, Extracellular, Neuroscience, Tortuosity and Cerebellum. In his study, which falls under the umbrella issue of Biophysics, Extracellular fluid is strongly linked to Cerebellar cortex. The concepts of his Extracellular study are interwoven with issues in Cortical spreading depression, Tetramethylammonium, Anatomy, Iontophoresis and Intracellular.
His Cortical spreading depression research incorporates elements of Ionic bonding and Endocrinology. His research investigates the connection between Iontophoresis and topics such as Effective diffusion coefficient that intersect with problems in Diffusion equation. He has researched Cerebellum in several fields, including Stimulation, Nuclear magnetic resonance and Tetrodotoxin.
His scientific interests lie mostly in Extracellular, Effective diffusion coefficient, Biophysics, Iontophoresis and Neuroscience. His study in Extracellular is interdisciplinary in nature, drawing from both Glymphatic system and Tetramethylammonium. His biological study spans a wide range of topics, including Wakefulness, Sleep in non-human animals, Central nervous system and Interstitial fluid.
His work carried out in the field of Biophysics brings together such families of science as Cerebellum, Rat Cerebellum, Granular layer and Anomalous diffusion. His research investigates the link between Iontophoresis and topics such as Nanotechnology that cross with problems in Matrix and Small molecule. The various areas that Charles Nicholson examines in his Neuroscience study include Cognitive science and Tetraethylammonium.
His main research concerns Glymphatic system, Extracellular, Biophysics, Iontophoresis and Matrix. Glymphatic system is frequently linked to Interstitial fluid in his study. His Interstitial fluid study combines topics from a wide range of disciplines, such as Cerebral cortex, Cerebrospinal fluid, Extracellular fluid and Central nervous system.
In his work, Transgene, Wakefulness and Sleep in non-human animals is strongly intertwined with Endocrinology, which is a subfield of Cerebrospinal fluid. His Extracellular research includes elements of Blood–brain barrier, Meningeal lymphatic vessels, Astrocyte, Immunology and Neuroscience. His Biophysics research incorporates themes from Effective diffusion coefficient, Extracellular matrix, Nanotechnology and Small molecule.
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Sleep Drives Metabolite Clearance From the Adult Brain
Lulu Xie;Hongyi Kang;Qiwu Xu;Michael J. Chen.
Diffusion in brain extracellular space.
Eva Syková;Charles Nicholson.
Physiological Reviews (2008)
Extracellular space structure revealed by diffusion analysis
Charles Nicholson;Eva Syková.
Trends in Neurosciences (1998)
Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.
C Nicholson;J M Phillips.
The Journal of Physiology (1981)
Clearance systems in the brain—implications for Alzheimer disease
Jenna M. Tarasoff-Conway;Roxana O. Carare;Ricardo S. Osorio;Lidia Glodzik.
Nature Reviews Neurology (2015)
Theory of current source-density analysis and determination of conductivity tensor for anuran cerebellum
C. Nicholson;J. A. Freeman.
Journal of Neurophysiology (1975)
Experimental optimization of current source-density technique for anuran cerebellum.
J. A. Freeman;C. Nicholson.
Journal of Neurophysiology (1975)
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space
Robert G. Thorne;Charles Nicholson.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Diffusion and related transport mechanisms in brain tissue
Reports on Progress in Physics (2001)
Extracellular ionic variations during spreading depression
R.P. Kraio;C. Nicholson.
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