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Elizabeth M. J. Gillam

Elizabeth M. J. Gillam

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8897
World Ranking
18008
National Ranking
518

Overview

Elizabeth M. J. Gillam is affiliated with the University of Queensland in Australia. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in pharmacology, toxicology, and pharmaceutics. The work reflects a focus on molecular biology and pharmacology as core subfields, complemented by research in computational theory and mathematics, plant science, and endocrinology, diabetes, and metabolism.

The scientist's research topics cover several interconnected areas related to enzyme function and drug metabolism. These include pharmacogenetics and drug metabolism, enzyme catalysis and immobilization, computational drug discovery methods, steroid chemistry, genomics and phylogenetic studies, microbial metabolic engineering, and glycosylation and glycoproteins research.

Elizabeth M. J. Gillam has published extensively in several scientific journals and venues. Frequent publication venues include:

  • Drug Metabolism and Disposition
  • Journal of Biological Chemistry
  • Journal of Inorganic Biochemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Angewandte Chemie

Recent published works illustrate the focus on protein engineering, enzyme stability, and evolutionary biology. Notable papers include:

  • Engineering functional thermostable proteins using ancestral sequence reconstruction, 2022, Journal of Biological Chemistry
  • Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP), 2022, PLoS Computational Biology
  • Strigolactones and Shoot Branching: What Is the Real Hormone and How Does It Work?, 2023, Plant and Cell Physiology
  • Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability, 2020, Journal of Biological Chemistry
  • Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates, 2022, Molecular Biology and Evolution

Collaborative work is a significant aspect of their research output, with frequent co-authors including Raine E. S. Thomson, Yosephine Gumulya, Gabriel Foley, Connie M. Ross, and Mikael Bodén.

Best Publications

  • Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme

    E. M. J. Gillam;T. Baba;Bok-Ryang Kim;S. Ohmori

  • Drug metabolism by Escherichia coli expressing human cytochromes P450.

    A. Parikh;E. M. J. Gillam;F. P. Guengerich

  • Catalytic properties of polymorphic human cytochrome P450 1B1 variants

    Tsutomu Shimada;Junko Watanabe;Kaname Kawajiri;Thomas R. Sutter

  • Oxidation of indole by cytochrome P450 enzymes.

    E. M. J. Gillam;L. M. Notley;H. L. Cai;J. J. De Voss

  • Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

    H. Kim Crewe;Lisa M. Notley;Rebecca M. Wunsch;Martin S. Lennard

  • Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.

    Shimada T;Oda Y;Gillam Em;Guengerich Fp

  • Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.

    Junko Watanabe;Tsutomu Shimada;Elizabeth M. J. Gillam;Togo Ikuta

  • Oxidation of Xenobiotics by Recombinant Human Cytochrome P450 1B1

    T. Shimada;E. M. J. Gillam;T. R. Sutter;P. T. Strickland

  • Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

    T. Shimada;E. M. J. Gillam;Y. Oda;F. Tsumura

  • Expression of Modified Human Cytochrome P450 2E1 in Escherichia coli, Purification, and Spectral and Catalytic Properties

    E. M. J. Gillam;Zuyu Guo;F. P. Guengerich

  • Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies

    F Peter Guengerich;Young-Jin Chun;Donghak Kim;Elizabeth M.J Gillam

  • Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

    E. M. J. Gillam;Zuyu Guo;Yuen-Fang Ueng;H. Yamazaki

  • Formation of Indigo by Recombinant Mammalian Cytochrome P450

    Elizabeth M.J. Gillam;Anna Marie A. Aguinaldo;Lisa M. Notley;Donghak Kim

  • Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions

    H. Yamazaki;E. M. J. Gillam;M.-S. Dong;W. W. Johnson

  • Engineering highly functional thermostable proteins using ancestral sequence reconstruction

    Yosephin Gumulya;Yosephin Gumulya;Jong-Min Baek;Shun-Jie Wun;Raine E. S. Thomson

  • Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization.

    E. M. J. Gillam;Zuyu Guo;M. V. Martin;C. M. Jenkins

  • Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties.

    Zuyo Guo;E. M. J. Gillam;S. Ohmori;R. H. Tukey

  • New Applications of Bacterial Systems to Problems in Toxicology

    F. P. Guengerich;E. M. J. Gillam;T. Shimada

  • Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the ‘retro’ approach to protein engineering

    Yosephine Gumulya;Elizabeth M.J. Gillam

  • Formation of indigo by recombinant mammalian cytochrome P450

    D. Kim;E. M. J. Gillam;A. M. Aguinaldo;L. Notley

Frequent Co-Authors

Tsutomu Shimada
Tsutomu Shimada Osaka Metropolitan University
F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Hiroshi Yamazaki
Hiroshi Yamazaki Showa Pharmaceutical University
Paul V. Bernhardt
Paul V. Bernhardt University of Queensland
Peter R. Dodd
Peter R. Dodd University of Queensland
Thomas R. Sutter
Thomas R. Sutter University of Memphis
Graeme R. Hanson
Graeme R. Hanson University of Queensland
John O. Miners
John O. Miners Flinders University
Rita Bernhardt
Rita Bernhardt Saarland University
Frances H. Arnold
Frances H. Arnold California Institute of Technology

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