D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 40 Citations 6,607 103 World Ranking 17116 National Ranking 508

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • Gene
  • DNA

Elizabeth M. J. Gillam mostly deals with Biochemistry, Enzyme, Cytochrome P450, Escherichia coli and Molecular biology. Her Reductase study, which is part of a larger body of work in Enzyme, is frequently linked to Recombinant expression, bridging the gap between disciplines. Elizabeth M. J. Gillam interconnects Microsome and Stereochemistry in the investigation of issues within Cytochrome P450.

Her Stereochemistry study integrates concerns from other disciplines, such as Aryl Hydrocarbon Hydroxylases, Isozyme and Pyrene. Her work carried out in the field of Escherichia coli brings together such families of science as Bacteria, Peptide sequence, Epoxide hydrolase and Benzopyrene. Her Molecular biology study which covers Recombinant DNA that intersects with Complementary DNA and Nucleic acid sequence.

Her most cited work include:

  • Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme (306 citations)
  • Drug metabolism by Escherichia coli expressing human cytochromes P450. (250 citations)
  • Catalytic properties of polymorphic human cytochrome P450 1B1 variants (249 citations)

What are the main themes of her work throughout her whole career to date?

Her primary scientific interests are in Biochemistry, Cytochrome P450, Enzyme, Stereochemistry and Escherichia coli. In her study, Nucleic acid sequence is inextricably linked to Molecular biology, which falls within the broad field of Biochemistry. Her Cytochrome P450 research integrates issues from Metabolite, Cytochrome, Drug metabolism and Heme.

The various areas that Elizabeth M. J. Gillam examines in her Enzyme study include Directed evolution, Mutant and Heterologous expression. The concepts of her Stereochemistry study are interwoven with issues in Residue, Active site, Monooxygenase and CYP1A2. Her Escherichia coli research is multidisciplinary, incorporating elements of Peptide sequence, Substrate, Genotoxicity and Benzopyrene.

She most often published in these fields:

  • Biochemistry (57.14%)
  • Cytochrome P450 (46.43%)
  • Enzyme (40.71%)

What were the highlights of her more recent work (between 2012-2020)?

  • Cytochrome P450 (46.43%)
  • Enzyme (40.71%)
  • Biochemistry (57.14%)

In recent papers she was focusing on the following fields of study:

Her scientific interests lie mostly in Cytochrome P450, Enzyme, Biochemistry, Directed evolution and Protein engineering. Her Cytochrome P450 research is multidisciplinary, incorporating perspectives in Molecular biology, Subfamily, Thermostability and Human brain. Her work on Cofactor, Reductase and Flavin adenine dinucleotide as part of general Enzyme study is frequently linked to Cytochrome c, therefore connecting diverse disciplines of science.

Biochemistry is represented through her Metabolite and Escherichia coli research. Her Escherichia coli research includes elements of Vertebrate and Recombinant DNA. Her research investigates the connection between Directed evolution and topics such as High-throughput screening that intersect with problems in Substrate.

Between 2012 and 2020, her most popular works were:

  • Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity. (45 citations)
  • Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the ‘retro’ approach to protein engineering (43 citations)
  • The evolution of cytochrome P450 enzymes as biocatalysts in drug discovery and development. (31 citations)

In her most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • DNA

Elizabeth M. J. Gillam mainly investigates Biochemistry, Directed evolution, Cytochrome P450, Enzyme and Biocatalysis. Biochemistry and Enantiomer are commonly linked in her work. Her research in Directed evolution tackles topics such as Protein engineering which are related to areas like Evolutionary biology, Genetics, Molecular evolution, Synthetic biology and Gene.

The Cytochrome P450 study combines topics in areas such as Molecular biology, Hippocampus, Cortex and Human brain. Her research integrates issues of Metabolite, Inflammasome, Stereochemistry and Escherichia coli in her study of Enzyme. Her studies deal with areas such as Vertebrate and Ancestral reconstruction as well as Escherichia coli.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme

E. M. J. Gillam;T. Baba;Bok-Ryang Kim;S. Ohmori.
Archives of Biochemistry and Biophysics (1993)

481 Citations

Drug metabolism by Escherichia coli expressing human cytochromes P450.

A. Parikh;E. M. J. Gillam;F. P. Guengerich.
Nature Biotechnology (1997)

381 Citations

Catalytic properties of polymorphic human cytochrome P450 1B1 variants

Tsutomu Shimada;Junko Watanabe;Kaname Kawajiri;Thomas R. Sutter.
Carcinogenesis (1999)

378 Citations

Oxidation of indole by cytochrome P450 enzymes.

E. M. J. Gillam;L. M. Notley;H. L. Cai;J. J. De Voss.
Biochemistry (2000)

326 Citations

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

H. Kim Crewe;Lisa M. Notley;Rebecca M. Wunsch;Martin S. Lennard.
Drug Metabolism and Disposition (2002)

305 Citations

Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.

Shimada T;Oda Y;Gillam Em;Guengerich Fp.
Drug Metabolism and Disposition (2001)

286 Citations

Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.

Junko Watanabe;Tsutomu Shimada;Elizabeth M. J. Gillam;Togo Ikuta.
Pharmacogenetics (2000)

234 Citations

Oxidation of Xenobiotics by Recombinant Human Cytochrome P450 1B1

T. Shimada;E. M. J. Gillam;T. R. Sutter;P. T. Strickland.
Drug Metabolism and Disposition (1997)

208 Citations

Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

T. Shimada;E. M. J. Gillam;Y. Oda;F. Tsumura.
Chemical Research in Toxicology (1999)

203 Citations

Expression of Modified Human Cytochrome P450 2E1 in Escherichia coli, Purification, and Spectral and Catalytic Properties

E. M. J. Gillam;Zuyu Guo;F. P. Guengerich.
Archives of Biochemistry and Biophysics (1994)

198 Citations

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