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Biology and Biochemistry

D-Index
62
Citations
14781
World Ranking
10729
National Ranking
4657

Overview

Joanne N. Engel is affiliated with the University of California, San Francisco in the United States. Their research spans multiple disciplines with primary contributions in Biochemistry, Genetics and Molecular Biology, and Medicine. These broad fields are further concentrated into specific subfields including Molecular Biology, Genetics, Epidemiology, Surgery, and Microbiology.

The scientist's work covers diverse topics such as bacterial biofilms and quorum sensing, bacterial genetics and biotechnology, reproductive tract infections research, medical imaging techniques and applications, cancer research and treatments, urinary tract infections management, and lipid membrane structure and behavior.

Engel has published extensively, with a notable presence in prominent journals and conference proceedings. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • SSRN Electronic Journal
  • Proceedings of the National Academy of Sciences
  • European Journal of Nuclear Medicine and Molecular Imaging

Their most recent and significant papers include:

  • "Mechanotaxis directs Pseudomonas aeruginosa twitching motility," 2021, Proceedings of the National Academy of Sciences
  • "Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans," 2022, European Journal of Nuclear Medicine and Molecular Imaging
  • "Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo," 2023, Journal of the American Chemical Society
  • "Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis," 2023, The EMBO Journal
  • "Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria," 2021, Antimicrobial Agents and Chemotherapy

Engel collaborates regularly with several co-authors, with frequent collaborators including:

  • Jessica Sherry
  • Henriette Macmillan
  • Cherilyn A. Elwell
  • Marco J. Kühn
  • Yuki F. Inclán

Best Publications

  • Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

    P Gunning;P Ponte;H Okayama;J Engel

  • Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

    Phyllis Ponte;Sun-Yu Ng;Joanne Engel;Peter Gunning

  • Chlamydia cell biology and pathogenesis.

    Cherilyn Elwell;Kathleen Mirrashidi;Joanne Engel

  • A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion

    Lian-Yong Gao;Su Guo;Bryant McLaughlin;Hiroshi Morisaki

  • Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa.

    Alan R. Hauser;Enesha Cobb;Maria Bodí;Dolors Mariscal

  • Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.

    Kim B Barken;Sunje J Pamp;Liang Yang;Morten Gjermansen

  • Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa

    Alexandre Persat;Yuki F. Inclan;Joanne N. Engel;Howard A. Stone

  • Role of Pseudomonas aeruginosa type III effectors in disease.

    Joanne Engel;Priya Balachandran

  • Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells

    Ama Gassama-Diagne;Ama Gassama-Diagne;Wei Yu;Martin ter Beest;Martin ter Beest;Fernando Martin-Belmonte

  • Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia

    James C. Comolli;Alan R. Hauser;Leslie Waite;Cynthia B. Whitchurch

  • Chlamydial Intracellular Survival Strategies

    Robert J. Bastidas;Cherilyn A. Elwell;Joanne N. Engel;Raphael H. Valdivia

  • Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa

    Cynthia B. Whitchurch;Andrew J. Leech;Michael D. Young;Derek Kennedy;Derek Kennedy

  • PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence.

    Alan R. Hauser;Pil Jung Kang;Joanne N. Engel

  • The Second Type VI Secretion System of Pseudomonas aeruginosa Strain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells

    Thibault G. Sana;Abderrahman Hachani;Iwona Bucior;Chantal Soscia

  • The Arginine Finger Domain of ExoT Contributes to Actin Cytoskeleton Disruption and Inhibition of Internalization of Pseudomonas aeruginosa by Epithelial Cells and Macrophages

    L. Garrity-Ryan;B. Kazmierczak;R. Kowal;J. Comolli

  • Pseudomonas aeruginosa Pili and Flagella mediate distinct binding and signaling events at the apical and basolateral surface of airway epithelium

    Iwona Bucior;Julia F. Pielage;Joanne N. Engel

  • Pseudomonas aeruginosa Induces Type-III-Secretion-Mediated Apoptosis of Macrophages and Epithelial Cells

    Alan R. Hauser;Joanne N. Engel

  • Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi.

    Jason M. Peters;Jason M. Peters;Byoung-Mo Koo;Ramiro Patino;Gary E. Heussler

  • Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

    Cherilyn A. Elwell;Shaobo Jiang;Jung Hwa Kim;Albert Lee

  • RNA Interference Screen Identifies Abl Kinase and PDGFR Signaling in Chlamydia trachomatis Entry

    Cherilyn A. Elwell;Alhaji Ceesay;Jung Hwa Kim;Daniel Kalman

Frequent Co-Authors

Keith E. Mostov
Keith E. Mostov University of California, San Francisco
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Don Ganem
Don Ganem Via Nova Therapeutics
Alan R. Hauser
Alan R. Hauser Northwestern University
Cynthia B. Whitchurch
Cynthia B. Whitchurch University of Technology Sydney
Peter W. Gunning
Peter W. Gunning University of New South Wales
Larry Kedes
Larry Kedes University of Southern California
Jeffrey R. Johnson
Jeffrey R. Johnson Icahn School of Medicine at Mount Sinai
Michael A. Matthay
Michael A. Matthay University of California, San Francisco
John S. Mattick
John S. Mattick University of New South Wales

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