Timothy F. Osborne

Overview

Best Publications

• Guidelines for the use and interpretation of assays for monitoring autophagy

  Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  8665
  Citations

• Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.

  Sean B. Joseph;Bryan A. Laffitte;Parthive H. Patel;Michael A. Watson

  913
  Citations

• Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

  William A. Freed-Pastor;Hideaki Mizuno;Xi Zhao;Anita Langerød

  894
  Citations

• Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

  Timothy F. Osborne

  745
  Citations

• SREBPs: Metabolic Integrators in Physiology and Metabolism

  Tae Il Jeon;Timothy F. Osborne

  626
  Citations

• HMG CoA Reductase: A Negatively Regulated Gene with Unusual Promoter and 5' Untranslated Regions

  Gary A. Reynolds;Sandip K. Basu;Timothy F. Osborne;Daniel J. Chin

  568
  Citations

• Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

  Yoko Kidani;Heidi Elsaesser;M Benjamin Hock;M Benjamin Hock;Laurent Vergnes

  558
  Citations

• Sterol Regulation of Fatty Acid Synthase Promoter COORDINATE FEEDBACK REGULATION OF TWO MAJOR LIPID PATHWAYS

  Mary K. Bennett;Jose M. Lopez;Hugo B. Sanchez;Timothy F. Osborne

  480
  Citations

• Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

  Marisa M. Magaña;Timothy F. Osborne

  476
  Citations

• Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.

  Tilla S. Worgall;Tilla S. Worgall;Stephen L. Sturley;Toru Seo;Toru Seo;Timothy F. Osborne

  448
  Citations

• Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene

  Hugo B. Sanchez;Lynn Yieh;Timothy F. Osborne

  422
  Citations

• A feed-forward loop amplifies nutritional regulation of PNPLA3.

  Yongcheng Huang;Shaoqing He;John Zhong Li;Young Kyo Seo

  414
  Citations

• Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein -1a

  Seung Soon Im;Leyla Yousef;Christoph Blaschitz;Janet Z. Liu

  397
  Citations

• Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

  Mathieu Blanc;Wei Yuan Hsieh;Kevin A. Robertson;Steven Watterson

  334
  Citations

• Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid

  Jose M. Lopez;Mary K. Bennett;Hugo B. Sanchez;John M. Rosenfeld

  333
  Citations

• Thyroid Hormone Regulation and Cholesterol Metabolism Are Connected through Sterol Regulatory Element-binding Protein-2 (SREBP-2)

  Dong Ju Shin;Timothy F. Osborne

  326
  Citations

• Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene

  Jeffrey R. Smith;Timothy F. Osborne;Joseph L. Goldstein;Michael S. Brown

  304
  Citations

• Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

  Timothy F. Osborne;Peter J. Espenshade

  286
  Citations

• A Direct Role for Sterol Regulatory Element Binding Protein in Activation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene

  Shawn Millinder Vallett;Hugo B. Sanchez;John M. Rosenfeld;Timothy F. Osborne

  280
  Citations

• Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

  Selma Masri;Paul Rigor;Marlene Cervantes;Nicholas Ceglia

  274
  Citations