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D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
25311
World Ranking
2857
National Ranking
210

Overview

Thomas E. Willnow is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research spans multiple fields, primarily within biochemistry, genetics, and molecular biology, with significant contributions to medicine as well.

The scientist's work covers several specialized subfields, including molecular biology, physiology, surgery, neurology, and genetics. These areas reflect a broad focus on both fundamental biological processes and clinical implications.

Major research topics addressed by Thomas E. Willnow include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and neurodegeneration mechanisms
  • Renal and related cancers
  • Pancreatic function and diabetes
  • Metabolism, diabetes, and cancer
  • Peroxisome proliferator-activated receptors
  • Immune cells in cancer

The scientist has published consistently in several recognized venues. Notably, these include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Glia
  • Alzheimer's & Dementia
  • Kidney International

Frequent collaborators include Vanessa Schmidt, Anna R. Malik, Annabel Christ, Sebastian Diecke, and Peter Lund Ovesen, indicating ongoing partnerships in their research efforts.

Among recent publications by Thomas E. Willnow are:

  • "Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames" (2023), published in Molecular Cell
  • "Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity" (2020), published in Nature Communications
  • "VPS10P Domain Receptors: Sorting Out Brain Health and Disease" (2020), published in Trends in Neurosciences
  • "SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis" (2020), published in Glia
  • "Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling" (2020), published in Alzheimer's & Dementia

Best Publications

  • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

    Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu

  • Sortilin is essential for proNGF-induced neuronal cell death

    Anders Nykjaer;Ramee Lee;Kenneth K. Teng;Pernille Jansen;Pernille Jansen

  • An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3

    Anders Nykjaer;Duska Dragun;Diego Walther;Henrik Vorum

  • Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

    Olav M. Andersen;Juliane Reiche;Vanessa Schmidt;Michael Gotthardt

  • Defective forebrain development in mice lacking gp330/megalin

    Thomas E. Willnow;Jan Hilpert;Scott A. Armstrong;Astrid Rohlmann

  • Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

    Thomas E. Willnow;Joseph L Goldstein;Kim A Orth;Michael S Brown

  • Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria

    Jörg-Robert Leheste;Boris Rolinski;Henrik Vorum;Jan Hilpert

  • Role of endocytosis in cellular uptake of sex steroids.

    Annette Hammes;Thomas K. Andreassen;Robert Spoelgen;Jens Raila

  • p75NTR--live or let die.

    Anders Nykjaer;Thomas E Willnow;Claus Munck Petersen

  • Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist

    Thomas E. Willnow;Zeqi Sheng;Shun Ishibashi;Joachim Herz

  • RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

    T E Willnow;A Rohlmann;J Horton;H Otani

  • Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

    Thomas E. Willnow;Scott A. Armstrong;Robert E. Hammer;Joachim Herz

  • Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

    Henrik Birn;John C. Fyfe;Christian Jacobsen;Francoise Mounier

  • Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).

    Anders Nykjaer;John C. Fyfe;Renata Kozyraki;Jörg Robert Leheste

  • Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

    Pernille Jansen;Klaus Giehl;Klaus Giehl;Jens R Nyengaard;Kenneth Teng

  • VPS10P-domain receptors — regulators of neuronal viability and function

    Thomas E. Willnow;Claus M. Petersen;Anders Nykjaer

  • Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule

    Sabine Amsellem;Jakub Gburek;Ghislaine Hamard;Rikke Nielsen

  • Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

    Renata Kozyraki;John Fyfe;Pierre J. Verroust;Christian Jacobsen

  • The low-density lipoprotein receptor gene family: a cellular Swiss army knife?

    Anders Nykjaer;Thomas E. Willnow

  • Lipoprotein receptors: New roles for ancient proteins

    Thomas E. Willnow;Anders Nykjaer;Joachim Herz

Frequent Co-Authors

Anders Nykjaer
Anders Nykjaer Aarhus University
Joachim Herz
Joachim Herz The University of Texas Southwestern Medical Center
Erik Ilsø Christensen
Erik Ilsø Christensen Aarhus University
Christian Jacobsen
Christian Jacobsen Aarhus University
Claus Munck Petersen
Claus Munck Petersen Aarhus University
Pierre J. Verroust
Pierre J. Verroust Aarhus University
Søren K. Moestrup
Søren K. Moestrup Aarhus University
Olaf Wolkenhauer
Olaf Wolkenhauer University of Rostock
Bradley T. Hyman
Bradley T. Hyman Harvard University
Michael Gotthardt
Michael Gotthardt University of Bonn

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