His primary areas of investigation include Molecular biology, Biochemistry, Dihydrofolate reductase, Gene duplication and Gene. His biological study spans a wide range of topics, including DNA, Cell culture, Chinese hamster ovary cell and Methotrexate. While the research belongs to areas of Cell culture, he spends his time largely on the problem of Cell cycle, intersecting his research to questions surrounding Gene rearrangement and Cell biology.
His study looks at the relationship between Biochemistry and fields such as Oviduct, as well as how they intersect with chemical problems. His Gene duplication research is multidisciplinary, incorporating elements of Drug resistance and DNA replication. His studies in RNA integrate themes in fields like Dihydrofolate reductase activity and Messenger RNA.
Molecular biology, Biochemistry, Gene, Dihydrofolate reductase and Cell culture are his primary areas of study. The study incorporates disciplines such as Methotrexate, Chinese hamster ovary cell, DNA, Messenger RNA and Gene duplication in addition to Molecular biology. Robert T. Schimke has researched Methotrexate in several fields, including Flow cytometry and Drug resistance.
Robert T. Schimke interconnects Complementary DNA, Oviduct and Protein biosynthesis in the investigation of issues within Messenger RNA. His Gene study introduces a deeper knowledge of Genetics. His Cell culture study integrates concerns from other disciplines, such as Cell cycle, Cell and Cell growth.
Robert T. Schimke mainly investigates Molecular biology, Cell culture, Chinese hamster ovary cell, Cell cycle and Gene. His studies deal with areas such as Gene expression, DNA, DNA synthesis, Transfection and Enzyme as well as Molecular biology. His Cell culture study combines topics from a wide range of disciplines, such as Genetic transfer, Growth medium, Immunology and Cytotoxicity.
The various areas that Robert T. Schimke examines in his Chinese hamster ovary cell study include Multiple drug resistance, Methotrexate, Dihydrofolate reductase, Biochemistry and Hamster. His study in Dihydrofolate reductase is interdisciplinary in nature, drawing from both Trimetrexate, Antifolate and Drug resistance. Robert T. Schimke interconnects Cell growth and Cell biology in the investigation of issues within Cell cycle.
Robert T. Schimke spends much of his time researching Molecular biology, Cell cycle, Cell biology, Mitosis and Cell culture. His studies in Molecular biology integrate themes in fields like Gene expression, Gene, Chinese hamster ovary cell and DNA synthesis. In general Gene, his work in Gene knockdown and Gene duplication is often linked to Transmembrane protein and Peptide transport linking many areas of study.
His biological study spans a wide range of topics, including Apoptosis and Cell cycle phase. His Transfection study in the realm of Cell culture interacts with subjects such as Sodium. In his study, Antifolate is inextricably linked to Dihydrofolate reductase, which falls within the broad field of Multiple drug resistance.
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Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.
F W Alt;R E Kellems;J R Bertino;R T Schimke.
Journal of Biological Chemistry (1978)
Gene amplification in cultured animal cells
Robert T. Schimke.
Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver.
Irwin M. Arias;Darrell Doyle;Robert T. Schimke.
Journal of Biological Chemistry (1969)
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase
Annie C. Y. Chang;Jack H. Nunberg;Randal J. Kaufman;Henry A. Erlich.
Micro assay for 3-hdyroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts
David J. Shapiro;Jeffrey L. Nordstrom;Jonathan J. Mitschelen;Victor W. Rodwell.
Biochimica et Biophysica Acta (1974)
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line
Jack H. Nunberg;Randal J. Kaufman;Robert T. Schimke;Gail Urlaub.
Proceedings of the National Academy of Sciences of the United States of America (1978)
Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.
Randal J. Kaufman;Peter C. Brown;Robert T. Schimke.
Proceedings of the National Academy of Sciences of the United States of America (1979)
Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I.
M P Wickens;G N Buell;R T Schimke.
Journal of Biological Chemistry (1978)
Gene amplification and drug resistance in cultured murine cells
Robert T. Schimke;Randal J. Kaufman;Fred W. Alt;Rodney F. Kellems.
Identification and Isolation of Ovalbumin-synthesizing Polysomes I. SPECIFIC BINDING OF 125I-ANTI-OVALBUMIN TO POLYSOMES
Rafael Palacios;Richard D. Palmiter;Robert T. Schimke.
Journal of Biological Chemistry (1972)
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