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Biology and Biochemistry

D-Index
65
Citations
34091
World Ranking
8930
National Ranking
3964

Research.com Recognitions

  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Thea D. Tlsty is affiliated with the University of California, San Francisco in the United States. Their research contributions span several fields, primarily focused on medicine and biochemistry, genetics, and molecular biology. Within these domains, they have notable work in molecular biology, surgery, oncology, immunology, and pulmonary and respiratory medicine.

Their recent publications illustrate a focus on cancer biology, cell interactions, and multi-omics approaches. Notable papers include:

  • A framework for advancing our understanding of cancer-associated fibroblasts, 2020, Nature reviews. Cancer
  • Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition, 2023, Gastroenterology
  • Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution, 2022, Cell Systems
  • Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis, 2023, bioRxiv (Cold Spring Harbor Laboratory)
  • Defining precancer: a grand challenge for the cancer community, 2024, Nature reviews. Cancer

Thea D. Tlsty's main research topics cover areas such as esophageal cancer research and treatment, epigenetics and DNA methylation, cancer cells and metastasis, immune cells in cancer, single-cell and spatial transcriptomics, CAR-T cell therapy research, and cancer genomics and diagnostics.

Frequent collaborators include Philippe Gascard, Lorenzo Ferri, Sophie Camilleri-Broët, David L. Gibbs, and Veena Sangwan. Thea D. Tlsty's work has appeared repeatedly in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Gastroenterology, Cancer Research, Nature reviews. Cancer, and Cell Systems.

Thea D. Tlsty has been recognized with the title of Fellow of the American Association for the Advancement of Science (AAAS), awarded in 2001.

Best Publications

  • Integrative analysis of 111 reference human epigenomes

    Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst

  • A framework for advancing our understanding of cancer-associated fibroblasts

    Erik Sahai;Igor Astsaturov;Edna Cukierman;David G. DeNardo

  • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.

    Aria F. Olumi;Gary D. Grossfeld;Simon W. Hayward;Peter R. Carroll

  • The clonal and mutational evolution spectrum of primary triple-negative breast cancers

    Sohrab P. Shah;Andrew Roth;Rodrigo Goya;Arusha Oloumi

  • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

    Laura R. Livingstone;Alicia White;Alicia White;Jason Sprouse;Jason Sprouse;Elizabeth Livanos;Elizabeth Livanos

  • Benign breast disease and the risk of breast cancer

    Lynn C. Hartmann;Thomas A. Sellers;Marlene H. Frost;Wilma L. Lingle

  • Tumor stroma and regulation of cancer development.

    Thea D. Tlsty;Lisa M. Coussens

  • Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

    Xu-Rong Jiang;Gretchen Jimenez;Edwin Chang;Maria Frolkis

  • Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

    Philippe Gascard;Thea D. Tlsty

  • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.

    Serguei R. Romanov;B. Krystyna Kozakiewicz;Charles R. Holst;Martha R. Stampfer

  • Know thy neighbor: stromal cells can contribute oncogenic signals

    Thea D Tlsty;Patrick W Hein

  • Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins

    Alicia E. White;Elizabeth M. Livanos;Thea D. Tlsty

  • DNA replication licensing and human cell proliferation

    Kai Stoeber;Thea D. Tlsty;Lisa Happerfield;Geraldine A. Thomas

  • Stromal cells can contribute oncogenic signals

    Thea D Tlsty

  • Biomarker Expression and Risk of Subsequent Tumors After Initial Ductal Carcinoma In Situ Diagnosis

    Karla Kerlikowske;Annette M. Molinaro;Mona L. Gauthier;Hal K. Berman

  • An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

    Antonio Gualberto;Kenneth Aldape;Krystyna Kozakiewicz;Thea D. Tlsty;Thea D. Tlsty

  • Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

    Charles R. Holst;Gerard J. Nuovo;Manel Esteller;Manel Esteller;Karen Chew

  • Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis

    Thea D. Tlsty;Barry H. Margolin;Karen Lum

  • Stratification of Breast Cancer Risk in Women With Atypia: A Mayo Cohort Study

    Amy C. Degnim;Daniel W. Visscher;Hal K. Berman;Marlene H. Frost

  • Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

    P C Brown;T D Tlsty;R T Schimke

Frequent Co-Authors

Joseph F. Costello
Joseph F. Costello University of California, San Francisco
Martin Hirst
Martin Hirst University of British Columbia
Marco A. Marra
Marco A. Marra University of British Columbia
Karla Kerlikowske
Karla Kerlikowske University of California, San Francisco
Peggy J. Farnham
Peggy J. Farnham University of Southern California
Ting Wang
Ting Wang Washington University in St. Louis
Robert T. Schimke
Robert T. Schimke Stanford University
Keith L. Ligon
Keith L. Ligon Harvard University
Steven J.M. Jones
Steven J.M. Jones University of British Columbia
Richard A. Moore
Richard A. Moore BC Cancer Agency

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