World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
16538
World Ranking
15386
National Ranking
6424

Overview

Haifa Shen is affiliated with Houston Methodist in the United States and has a significant body of research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work extensively covers subfields such as Molecular Biology, Infectious Diseases, Immunology, Biomedical Engineering, and Oncology.

Shen's recent scholarly contributions include several papers published in reputable journals. Notable publications are:

  • Algorithm for optimized mRNA design improves stability and immunogenicity, 2023, Nature
  • MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic, 2021, Frontiers in Cell and Developmental Biology
  • Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages, 2020, Nature Communications
  • Nanoplatforms for mRNA Therapeutics, 2020, Advanced Therapeutics
  • TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells, 2022, Science Immunology

Their research interests revolve around key topics such as RNA Interference and Gene Delivery, SARS-CoV-2 and COVID-19 Research, Immunotherapy and Immune Responses, Nanoparticle-Based Drug Delivery, Animal Virus Infections Studies, Nanoplatforms for cancer theranostics, and Viral Infections and Immunology Research.

Shen frequently publishes in scientific venues including Science Advances, Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Advanced Therapeutics, and Pharmaceutics.

Collaboration plays a substantial role in Shen's research activities. Frequent coauthors include Junhua Mai, Hangwen Li, Mauro Ferrari, Yongbin Liu, and Shreya Goel, indicating an interdisciplinary and collaborative approach to scientific investigation.

Best Publications

  • Principles of nanoparticle design for overcoming biological barriers to drug delivery

    Elvin Blanco;Haifa Shen;Haifa Shen;Mauro Ferrari;Mauro Ferrari

  • XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

    Xi Chen;Dimitrios Iliopoulos;Dimitrios Iliopoulos;Qing Zhang;Qianzi Tang;Qianzi Tang

  • Safety of Nanoparticles in Medicine.

    Joy Wolfram;Motao Zhu;Yong Yang;Jianliang Shen;Jianliang Shen

  • New genes involved in cancer identified by retroviral tagging

    Takeshi Suzuki;Haifa Shen;Keiko Akagi;Herbert C Morse

  • Leukaemia disease genes: large-scale cloning and pathway predictions

    Jiayin Li;Haifa Shen;Karen L. Himmel;Adam J. Dupuy

  • An injectable nanoparticle generator enhances delivery of cancer therapeutics

    Rong Xu;Rong Xu;Rong Xu;Guodong Zhang;Guodong Zhang;Junhua Mai;Junhua Mai;Xiaoyong Deng;Xiaoyong Deng;Xiaoyong Deng

  • The nano-plasma interface: Implications of the protein corona.

    Joy Wolfram;Yong Yang;Jianliang Shen;Asad Moten

  • Nanovector delivery of siRNA for cancer therapy.

    Haifa Shen;T. Sun;Mauro Ferrari

  • Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics

    Jianliang Shen;Han Cheon Kim;Hua Su;Feng Wang

  • Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination

    Stefano Persano;Maria L. Guevara;Zhaoqi Li;Junhua Mai

  • The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth

    Haifa Shen;Philip N. Heacock;Constance J. Clancey;William Dowhan

  • Transport properties of pancreatic cancer describe gemcitabine delivery and response

    Eugene J. Koay;Mark J. Truty;Vittorio Cristini;Ryan M. Thomas;Ryan M. Thomas

  • Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

    Na Zhao;Jin Cao;Longyong Xu;Qianzi Tang

  • Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy.

    Gianfranco Pasut;Donatella Paolino;Christian Celia;Anna Mero

  • SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy.

    Feng Wang;Feng Wang;Xiaojun Xia;Xiaojun Xia;Chunying Yang;Jianliang Shen

  • Targeting Autocrine CCL5–CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity

    Yi Ban;Junhua Mai;Xin Li;Marisa Mitchell-Flack

  • Cyclic cRGDfk peptide and Chlorin e6 functionalized silk fibroin nanoparticles for targeted drug delivery and photodynamic therapy.

    Baiping Mao;Caixia Liu;Wenwen Zheng;Xiaoheng Li

  • A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

    Joy Wolfram;Joy Wolfram;Sara Nizzero;Sara Nizzero;Haoran Liu;Feng Li

  • Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics

    Jianliang Shen;Wei Zhang;Ruogu Qi;Zong Wan Mao;Zong Wan Mao

  • E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis

    Shuangtao Ma;Xiao Yu Tian;Xiao Yu Tian;Yunrong Zhang;Chaofeng Mu

Frequent Co-Authors

Mauro Ferrari
Mauro Ferrari Houston Methodist
Xuewu Liu
Xuewu Liu Houston Methodist
Zong-Wan Mao
Zong-Wan Mao Sun Yat-sen University
Yuliang Zhao
Yuliang Zhao National Center for Nanoscience and Technology, China
Cristian Rodriguez-Aguayo
Cristian Rodriguez-Aguayo The University of Texas MD Anderson Cancer Center
Xiaojing Ma
Xiaojing Ma Shanghai Jiao Tong University
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center
Jenny C. Chang
Jenny C. Chang Houston Methodist
William Dowhan
William Dowhan The University of Texas Health Science Center at Houston

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