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Domenico Praticò

Domenico Praticò

D-Index & Metrics

Medicine

D-Index
102
Citations
45170
World Ranking
7571
National Ranking
3949

Overview

Domenico Praticò is affiliated with Temple University in the United States. Their research encompasses various aspects of medicine and biochemistry, genetics, and molecular biology, with primary contributions in the fields of physiology, molecular biology, neurology, surgery, and pharmacology.

The scientist's work focuses significantly on topics related to Alzheimer's disease research and treatments, cholesterol and lipid metabolism, cholinesterase and neurodegenerative diseases, neuroinflammation and neurodegeneration mechanisms, autophagy in disease and therapy, drug transport and resistance mechanisms, as well as Down syndrome and intellectual disability research.

Among recent publications, notable papers include:

  • "Glycogen synthase kinase-3 signaling in Alzheimer's disease," 2020, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • "Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics," 2021, Pharmacology & Therapeutics
  • "ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments," 2022, Cell Death and Disease
  • "Inflammation in atherosclerosis: pathophysiology and mechanisms," 2024, Cell Death and Disease
  • "A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles," 2020, Molecular Neurodegeneration

Domenico Praticò frequently collaborates with several researchers, including:

  • Amir Ajoolabady
  • Jun Ren
  • Nicholas N. Lyssenko
  • Elisabetta Lauretti
  • Suhad Bahijri

Their research has been published repeatedly in these venues:

  • Journal of Alzheimer s Disease
  • Annals of Neurology
  • Molecular Psychiatry
  • Pharmacology & Therapeutics
  • Ageing Research Reviews

Domenico Praticò's work integrates multiple disciplines and therapeutic approaches, focusing on molecular and cellular mechanisms underlying neurodegenerative diseases and associated pathologies. The diversity in both topics and publication venues reflects a broad engagement with neuroscience, molecular biology, and clinical therapeutic research.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

    Domenico Praticò;Kunihiro Uryu;Susan Leight;John Q. Trojanoswki

  • Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

    Domenico Praticò;Christopher M. Clark;Feyan Liun;Virginia Y.-M. Lee

  • Modulation of monocyte-endothelial cell interactions by platelet microparticles.

    Orla P. Barry;Domenico Praticò;Rashmin C. Savani;Garret A. FitzGerald

  • Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice.

    Domenico Praticò;Rajendra K. Tangirala;Daniel J. Rader;Joshua Rokach

  • Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

    Domenico Praticò

  • Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles.

    O P Barry;D Pratico;J A Lawson;G A FitzGerald

  • Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease.

    Domenico Praticò;Norman Delanty

  • Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo

    Domenico Pratico;Virginia M.-Y. Lee;John Q. Trojanowski;Joshua Rokach

  • Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

    D Praticò;L Iuliano;A Mauriello;L Spagnoli

  • Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity.

    Domenico Praticò;Christopher M. Clark;Virginia M.‐Y. Lee;John Q. Trojanowski

  • Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells.

    Monika Baj-Krzyworzeka;Marcin Majka;Domenico Pratico;Janina Ratajczak

  • Adverse cardiovascular effects of the coxibs.

    Jean-Michel Dogné;Claudiu T Supuran;Domenico Pratico

  • Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis

    Kunihiro Uryu;Helmut Laurer;Tracy McIntosh;Domenico Praticò

  • Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

    Domenico Praticò

  • Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease

    Syuan Sung;Yuemang Yao;Kunihiro Uryu;Hengxuan Yang

  • 8-Epi PGF2α Generation During Coronary Reperfusion

    N. Delanty;M.P. Reilly;D. Pratico;J.A. Lawson

  • Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α

    Domenico Pratico;John A. Lawson;Garret A. FitzGerald

  • Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions.

    Sigrid C Veasey;Christine W Davis;Polina Fenik;Guanxia Zhan

  • Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice

    Domenico Praticò;Kunihiro Uryu;Syan Sung;Sei Tang

Frequent Co-Authors

Garret A. FitzGerald
Garret A. FitzGerald University of Pennsylvania
Joshua Rokach
Joshua Rokach Florida Institute of Technology
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Francesco Violi
Francesco Violi Sapienza University of Rome
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Mony J. de Leon
Mony J. de Leon Cornell University
Christopher M. Clark
Christopher M. Clark University of Pennsylvania
Kaj Blennow
Kaj Blennow University of Gothenburg
Colin D. Funk
Colin D. Funk Queen's University
Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University

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