Douglas C. Dean mainly investigates Transcription factor, Molecular biology, Cell biology, E2F and Cancer research. His Transcription factor research incorporates elements of Tumor necrosis factor alpha and Jurkat cells. He has included themes like Histone H4, Chromatin remodeling, Histone H1 and EZH2 in his Molecular biology study.
His Cell biology research incorporates themes from Cyclin E, Histone methyltransferase, DNA repair and Histone H2A. Douglas C. Dean combines subjects such as Psychological repression, Promoter, Cyclin D1 and Phosphorylation with his study of E2F. Douglas C. Dean has included themes like Retinoblastoma and Regulation of gene expression in his Cell cycle study.
His primary areas of investigation include Cell biology, Molecular biology, Cancer research, Transcription factor and Cellular differentiation. His primary area of study in Cell biology is in the field of Stem cell. His Molecular biology research integrates issues from E2F, Transcription, Transfection, Promoter and Binding site.
His E2F research includes elements of Cyclin D1, Retinoblastoma protein and E2F1. Douglas C. Dean combines subjects such as Epithelial–mesenchymal transition, Cancer, Metastasis, Cancer cell and DNA repair with his study of Cancer research. His Transcription factor research focuses on Regulation of gene expression and how it relates to Mutation.
Douglas C. Dean mostly deals with Cell biology, Cancer research, Stem cell, Retinitis pigmentosa and Retinal. His Catenin study, which is part of a larger body of work in Cell biology, is frequently linked to MERTK, bridging the gap between disciplines. His Cancer research research is multidisciplinary, incorporating elements of Epithelial–mesenchymal transition, Cancer cell, Proinflammatory cytokine and Cornea.
His work focuses on many connections between Stem cell and other disciplines, such as Cellular differentiation, that overlap with his field of interest in Tumor progression, Progenitor cell, Cancer and Neurotrophin. His Retinitis pigmentosa research focuses on Retinal degeneration and how it connects with Outer nuclear layer, Endoplasmic reticulum and Transplantation. His Retinal study incorporates themes from Degeneration and Central vision.
Douglas C. Dean mainly focuses on Cell biology, Reprogramming, Retinal pigment epithelium, Interleukin and Proinflammatory cytokine. His Cell biology research is multidisciplinary, incorporating perspectives in Epithelial–mesenchymal transition, CD44 and Retinitis pigmentosa. The study incorporates disciplines such as Cancer cell, Cancer stem cell, Mitosis and Adult stem cell in addition to Reprogramming.
The Retinal pigment epithelium study combines topics in areas such as Protein kinase B, Hippo signaling pathway, SOX2, KLF4 and Stem cell. Interleukin combines with fields such as DNA repair, Inflammation, Inflammatory bowel disease, Colitis and DNA glycosylase in his investigation. His Proinflammatory cytokine study frequently links to other fields, such as Cancer research.
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The Rb/E2F pathway: expanding roles and emerging paradigms
J. William Harbour;Douglas C. Dean.
Genes & Development (2000)
Rb Interacts with Histone Deacetylase to Repress Transcription
Robin X Luo;Antonio A Postigo;Douglas C Dean.
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
J.William Harbour;Robin X Luo;Angeline Dei Santi;Antonio A Postigo.
Retinoblastoma protein switches the E2F site from positive to negative element.
Steven J. Weintraub;Cheryl A. Prater;Douglas C. Dean.
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.
H.Steven Zhang;Mark Gavin;Anjali Dahiya;Antonio A Postigo.
Mechanism of active transcriptional repression by the retinoblastoma protein
Steven J. Weintraub;Kevin N. B. Chow;Robin X. Luo;Steven H. Zhang.
Rb function in cell-cycle regulation and apoptosis
J. William Harbour;Douglas C. Dean.
Nature Cell Biology (2000)
Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).
M.F. Iademarco;J.J. McQuillan;G.D. Rosen;D.C. Dean.
Journal of Biological Chemistry (1992)
Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis
Glenn D. Rosen;Joshua R. Sanes;Rhonda LaChance;Jeanette M. Cunningham.
Active Transcriptional Repression by the Rb–E2F Complex Mediates G1 Arrest Triggered by p16INK4a, TGFβ, and Contact Inhibition
H.Steven Zhang;Antonio A Postigo;Douglas C Dean.
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