What is he best known for?
The fields of study he is best known for:
- Gene
- Transcription factor
- Enzyme
Douglas C. Dean mainly investigates Transcription factor, Molecular biology, Cell biology, E2F and Cancer research.
His Transcription factor research incorporates elements of Tumor necrosis factor alpha and Jurkat cells.
He has included themes like Histone H4, Chromatin remodeling, Histone H1 and EZH2 in his Molecular biology study.
His Cell biology research incorporates themes from Cyclin E, Histone methyltransferase, DNA repair and Histone H2A.
Douglas C. Dean combines subjects such as Psychological repression, Promoter, Cyclin D1 and Phosphorylation with his study of E2F.
Douglas C. Dean has included themes like Retinoblastoma and Regulation of gene expression in his Cell cycle study.
His most cited work include:
- The Rb/E2F pathway: expanding roles and emerging paradigms (982 citations)
- Rb Interacts with Histone Deacetylase to Repress Transcription (901 citations)
- Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1 (878 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Cell biology, Molecular biology, Cancer research, Transcription factor and Cellular differentiation.
His primary area of study in Cell biology is in the field of Stem cell.
His Molecular biology research integrates issues from E2F, Transcription, Transfection, Promoter and Binding site.
His E2F research includes elements of Cyclin D1, Retinoblastoma protein and E2F1.
Douglas C. Dean combines subjects such as Epithelial–mesenchymal transition, Cancer, Metastasis, Cancer cell and DNA repair with his study of Cancer research.
His Transcription factor research focuses on Regulation of gene expression and how it relates to Mutation.
He most often published in these fields:
- Cell biology (47.50%)
- Molecular biology (26.67%)
- Cancer research (20.00%)
What were the highlights of his more recent work (between 2017-2021)?
- Cell biology (47.50%)
- Cancer research (20.00%)
- Stem cell (12.50%)
In recent papers he was focusing on the following fields of study:
Douglas C. Dean mostly deals with Cell biology, Cancer research, Stem cell, Retinitis pigmentosa and Retinal.
His Catenin study, which is part of a larger body of work in Cell biology, is frequently linked to MERTK, bridging the gap between disciplines.
His Cancer research research is multidisciplinary, incorporating elements of Epithelial–mesenchymal transition, Cancer cell, Proinflammatory cytokine and Cornea.
His work focuses on many connections between Stem cell and other disciplines, such as Cellular differentiation, that overlap with his field of interest in Tumor progression, Progenitor cell, Cancer and Neurotrophin.
His Retinitis pigmentosa research focuses on Retinal degeneration and how it connects with Outer nuclear layer, Endoplasmic reticulum and Transplantation.
His Retinal study incorporates themes from Degeneration and Central vision.
Between 2017 and 2021, his most popular works were:
- Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa (22 citations)
- ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells (6 citations)
- Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells. (6 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Transcription factor
- Enzyme
Douglas C. Dean mainly focuses on Cell biology, Reprogramming, Retinal pigment epithelium, Interleukin and Proinflammatory cytokine.
His Cell biology research is multidisciplinary, incorporating perspectives in Epithelial–mesenchymal transition, CD44 and Retinitis pigmentosa.
The study incorporates disciplines such as Cancer cell, Cancer stem cell, Mitosis and Adult stem cell in addition to Reprogramming.
The Retinal pigment epithelium study combines topics in areas such as Protein kinase B, Hippo signaling pathway, SOX2, KLF4 and Stem cell.
Interleukin combines with fields such as DNA repair, Inflammation, Inflammatory bowel disease, Colitis and DNA glycosylase in his investigation.
His Proinflammatory cytokine study frequently links to other fields, such as Cancer research.
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