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Medicine

D-Index
88
Citations
22707
World Ranking
13352
National Ranking
421

Overview

Serge Adnot is affiliated with Paris-Est Créteil University in France and has an extensive research record primarily focused on medicine and biochemistry, genetics, and molecular biology. Their work encompasses several subfields, including physiology, pulmonary and respiratory medicine, molecular biology, immunology, and surgery.

The researcher has contributed substantially to the understanding of telomeres, telomerase, and cellular senescence, with a significant number of publications addressing neonatal respiratory health and pulmonary hypertension. Other main topics in their research include microRNA in disease regulation, genetics and aging in model organisms, neutrophil and oxidative mechanisms, as well as interstitial lung diseases and idiopathic pulmonary fibrosis.

Serge Adnot's frequent co-authors include Larissa Lipskaia, E. Born, Élisabeth Marcos, Amal Houssaïni, and Marielle Breau, indicating collaboration in both clinical and molecular research domains.

Their articles have appeared predominantly in venues such as:

  • Revue des Maladies Respiratoires
  • American Journal of Respiratory and Critical Care Medicine
  • Aging Cell
  • Bulletin de l Académie Nationale de Médecine
  • Circulation

Recently published papers illustrate the focus on senescence and pulmonary-related pathologies:

  • "Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression" (2022, Circulation)
  • "Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging" (2021, Circulation)
  • "Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters" (2023, Nature Aging)
  • "Stereotactic Lung Irradiation in Mice Promotes Long-Term Senescence and Lung Injury" (2020, International Journal of Radiation Oncology*Biology*Physics)
  • "Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction" (2023, JCI Insight)

These publications focus on cellular senescence mechanisms, pulmonary hypertension, cardiac aging, viral infection impacts on aged organisms, and age-related tissue remodeling, reflecting an intersection of molecular and clinical pulmonary research.

Overall, Serge Adnot's body of work integrates molecular biology with clinical respiratory medicine, addressing mechanisms of aging, inflammation, and pulmonary diseases through both experimental and translational approaches.

Best Publications

  • Cellular and molecular basis of pulmonary arterial hypertension.

    Nicholas W. Morrell;Serge Adnot;Stephen L. Archer;Jocelyn Dupuis

  • Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

    Saadia Eddahibi;Marc Humbert;Elie Fadel;Bernadette Raffestin

  • A hemodynamic study of pulmonary hypertension in sickle cell disease.

    Florence Parent;Dora Bachir;Jocelyn Inamo;François Lionnet

  • Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

    Benoît Ranchoux;Fabrice Antigny;Catherine Rucker-Martin;Aurélie Hautefort

  • Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia.

    S Adnot;B Raffestin;S Eddahibi;P Braquet

  • The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.

    Armin Hatzelmann;Esteban J. Morcillo;Giuseppe Lungarella;Serge Adnot

  • Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene

    S. Eddahibi;N. Hanoun;L. Lanfumey;K.P. Lesch

  • Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

    Saadia Eddahibi;Christophe Guignabert;Anne-Marie Barlier-Mur;Laurence Dewachter

  • Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease.

    Laurent Savale;Ari Chaouat;Sylvie Bastuji-Garin;Elisabeth Marcos

  • Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice

    Laurent Savale;Ly Tu;Dominique Rideau;Mohamed Izziki

  • 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

    Margaret R MacLean;Philippe Herve;Saadia Eddahibi;Serge Adnot

  • Genetic basis of pulmonary arterial hypertension: current understanding and future directions.

    John H Newman;Richard C Trembath;Jane A Morse;Ekkehard Grunig

  • Polymorphism of the Serotonin Transporter Gene and Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease

    Saadia Eddahibi;Ari Chaouat;Nicholas Morrell;Elie Fadel

  • Induction of Serotonin Transporter by Hypoxia in Pulmonary Vascular Smooth Muscle Cells Relationship With the Mitogenic Action of Serotonin

    S. Eddahibi;V. Fabre;C. Boni;M. P. Martres

  • Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension.

    Olivier Sanchez;Elisabeth Marcos;Frédéric Perros;Elie Fadel

  • Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.

    Elisabeth Marcos;Serge Adnot;Minh Hien Pham;Anne Nosjean

  • Serotonin-Induced Smooth Muscle Hyperplasia in Various Forms of Human Pulmonary Hypertension

    Elisabeth Marcos;Elie Fadel;Olivier Sanchez;Marc Humbert

  • Role for interleukin-6 in COPD-related pulmonary hypertension.

    Ari Chaouat;Laurent Savale;Christos Chouaid;Ly Tu

  • Serotonin Transporter Inhibition Prevents and Reverses Monocrotaline-Induced Pulmonary Hypertension in Rats

    Christophe Guignabert;Bernadette Raffestin;Rima Benferhat;William Raoul

  • Telomere Dysfunction Causes Sustained Inflammation in Chronic Obstructive Pulmonary Disease

    Amsellem;Gary-Bobo G;Marcos E;Maitre B

Frequent Co-Authors

Marc Humbert
Marc Humbert University of Paris-Saclay
Michel Hamon
Michel Hamon Université Paris Cité
Christian Brun-Buisson
Christian Brun-Buisson Institut Pasteur
Gérald Simonneau
Gérald Simonneau University of Paris-Saclay
Philippe Dartevelle
Philippe Dartevelle University of Luxembourg
Alain Harf
Alain Harf Grenoble Alpes University
Roger J. Hajjar
Roger J. Hajjar Icahn School of Medicine at Mount Sinai
Marc Eloit
Marc Eloit Institut Pasteur
Robert Naeije
Robert Naeije Université Libre de Bruxelles
Laurent Brochard
Laurent Brochard St. Michael's Hospital

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