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D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
16692
World Ranking
4888
National Ranking
363

Overview

Jacob Piehler is affiliated with Osnabrück University in Germany. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions to the fields of medicine as well. Subfields of study covered in their work include molecular biology, immunology, radiology, nuclear medicine and imaging, oncology, and cell biology.

Their research topics cover diverse aspects of molecular and cellular biology, including monoclonal and polyclonal antibodies research, advanced fluorescence microscopy techniques, T-cell and B-cell immunology, click chemistry and applications, cytokine signaling pathways and interactions, advanced biosensing techniques and applications, as well as immunotherapy and immune responses.

Jacob Piehler has collaborated frequently with several coauthors, including:

  • Rainer Kurre
  • Changjiang You
  • Stephan Wilmes
  • Michael Holtmannspötter
  • K. Christopher García

Their work has been published in multiple venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • eLife
  • Science Signaling
  • Nature Communications

Significant recent papers authored or coauthored by Jacob Piehler include:

  • Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations, 2020, Science
  • Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo, 2020, Cell stem cell
  • Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses, 2020, Science Signaling
  • IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein, 2022, Science Immunology
  • IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs, 2021, Science Signaling

Best Publications

  • High-affinity adaptors for switchable recognition of histidine-tagged proteins.

    Suman Lata;Annett Reichel;Roland Brock;Robert Tampé

  • Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

    Christoph Thomas;Ignacio Moraga;Doron Levin;Peter O. Krutzik

  • Helical Structures of ESCRT-III Are Disassembled by VPS4

    Suman Lata;Guy Schoehn;Ankur Jain;Ricardo Pires

  • Integrated optical Mach-Zehnder biosensor

    B.J. Luff;J.S. Wilkinson;J. Piehler;U. Hollenbach

  • Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

    Claudia Y. Janda;Luke T. Dang;Changjiang You;Junlei Chang

  • The receptor of the type I interferon family.

    G. Uzé;G. Schreiber;J. Piehler;S. Pellegrini

  • A high-density poly(ethylene glycol) polymer brush for immobilization on glass-type surfaces

    Jacob Piehler;Andreas Brecht;Ramūnas Valiokas;Bo Liedberg

  • New methodologies for measuring protein interactions in vivo and in vitro.

    Jacob Piehler

  • Differential Receptor Subunit Affinities of Type I Interferons Govern Differential Signal Activation

    Eva Jaks;Martynas Gavutis;Gilles Uzé;Jacques Martal

  • Inquiring into the Differential Action of Interferons (IFNs): an IFN-α2 Mutant with Enhanced Affinity to IFNAR1 Is Functionally Similar to IFN-β

    Diego A. Jaitin;Laila C. Roisman;Eva Jaks;Martynas Gavutis

  • Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

    Jacob Piehler;Christoph Thomas;K.Christopher Garcia;Gideon Schreiber

  • USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

    Véronique François-Newton;Gabriel Magno de Freitas Almeida;Béatrice Payelle-Brogard;Danièle Monneron

  • Surface modification for direct immunoprobes

    Jacob Piehler;Andreas Brecht;Kurt E. Geckeler;Günter Gauglitz

  • Specific and stable fluorescence labeling of histidine-tagged proteins for dissecting multi-protein complex formation

    Suman Lata;Martynas Gavutis;Robert Tampé;Jacob Piehler

  • The molecular basis for functional plasticity in type I interferon signaling.

    Gideon Schreiber;Jacob Piehler

  • Stable and functional immobilization of histidine-tagged proteins via multivalent chelator headgroups on a molecular poly(ethylene glycol) brush.

    Suman Lata;Jacob Piehler

  • New Structural and Functional Aspects of the Type I Interferon-Receptor Interaction Revealed by Comprehensive Mutational Analysis of the Binding Interface

    Jacob Piehler;Laila C. Roisman;Gideon Schreiber

  • Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria

    Patrice Rassam;Nikki A Copeland;Oliver Birkholz;Csaba Tóth

  • ISG15 deficiency and increased viral resistance in humans but not mice.

    Scott D. Speer;Zhi Li;Sofija Buta;Béatrice Payelle-Brogard

  • Determination of simazine in water samples by waveguide surface plasmon resonance

    C. Mouvet;R.D. Harris;C. Maciag;B.J. Luff

Frequent Co-Authors

K. Christopher Garcia
K. Christopher Garcia Stanford University
Robert Tampé
Robert Tampé Goethe University Frankfurt
Gideon Schreiber
Gideon Schreiber Weizmann Institute of Science
Bo Liedberg
Bo Liedberg Nanyang Technological University
James S. Wilkinson
James S. Wilkinson University of Southampton
Vijay G. Sankaran
Vijay G. Sankaran Harvard University
Giovanni Capellini
Giovanni Capellini Roma Tre University
Sandra Pellegrini
Sandra Pellegrini Institut Pasteur
Christian Ungermann
Christian Ungermann Osnabrück University
Colin Kleanthous
Colin Kleanthous University of Oxford

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