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Chemistry

D-Index
45
Citations
8442
World Ranking
16345
National Ranking
1288

Overview

Akio Ojida is affiliated with Kyushu University in Japan and has contributed extensively to the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Chemistry. Their research spans across several subfields including Molecular Biology, Organic Chemistry, Materials Chemistry, Oncology, and Physiology.

The primary topics in Akio Ojida's work include:

  • Click Chemistry and Applications
  • Peptidase Inhibition and Analysis
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Chemical Synthesis and Analysis
  • Protein Degradation and Inhibitors
  • Computational Drug Discovery Methods

Ojida's scientific output includes multiple recent papers, showcasing research in chemical biology, protein targeting, and medicinal chemistry. Notable papers include:

  • Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins, 2020, Journal of the American Chemical Society
  • Recent progress in covalent warheads for in vivo targeting of endogenous proteins, 2021, Bioorganic & Medicinal Chemistry
  • Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells, 2020, Chemical Communications
  • Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease, 2022, Journal of Medicinal Chemistry
  • Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines, 2020, ACS Medicinal Chemistry Letters

Frequent co-authors collaborating with Ojida include:

  • Naoya Shindo
  • Shohei Uchinomiya
  • Jirarut Wongkongkatep
  • Shigehiro Ohdo
  • Eiji Kawanishi

Ojida's research has appeared in various publication venues, with the most frequent being:

  • The Cambridge Structural Database
  • Journal of the American Chemical Society
  • Scientific Reports
  • Molecules
  • Journal of Medicinal Chemistry

Best Publications

  • Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

    Shigeki Kiyonaka;Kenta Kato;Motohiro Nishida;Kazuhiro Mio

  • First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution.

    Akio Ojida;Yasuko Mito-Oka;Masa Aki Inoue;Itaru Hamachi

  • Molecular recognition and fluorescence sensing of monophosphorylated peptides in aqueous solution by bis(zinc(II)-dipicolylamine)-based artificial receptors.

    Akio Ojida;Yasuko Mito-oka;Kazuki Sada;Itaru Hamachi

  • Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(II)–Dpa complexes

    Takashi Sakamoto;Akio Ojida;Itaru Hamachi

  • Turn-on fluorescence sensing of nucleoside polyphosphates using a xanthene-based Zn(II) complex chemosensor

    Akio Ojida;Ippei Takashima;Takahiro Kohira;Hiroshi Nonaka

  • Protein organic chemistry and applications for labeling and engineering in live-cell systems.

    Yousuke Takaoka;Akio Ojida;Itaru Hamachi

  • Ligand-directed acyl imidazole chemistry for labeling of membrane-bound proteins on live cells

    Sho Hei Fujishima;Ryosuke Yasui;Takayuki Miki;Akio Ojida

  • Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems

    Masayasu Taki;Shohei Iyoshi;Akio Ojida;Itaru Hamachi

  • Rational design of FRET-based ratiometric chemosensors for in vitro and in cell fluorescence analyses of nucleoside polyphosphates.

    Yasutaka Kurishita;Takahiro Kohira;Akio Ojida;Itaru Hamachi

  • Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor.

    Masayasu Taki;Mika Desaki;Akio Ojida;Shohei Iyoshi

  • Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients.

    Akio Ojida;Takashi Sakamoto;Masa Aki Inoue;Sho Hei Fujishima

  • Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip.

    Ibuki Yoshimura;Yoshifumi Miyahara;Noriyuki Kasagi;Hiroki Yamane

  • Organelle-Localizable Fluorescent Chemosensors for Site-Specific Multicolor Imaging of Nucleoside Polyphosphate Dynamics in Living Cells

    Yasutaka Kurishita;Takahiro Kohira;Akio Ojida;Itaru Hamachi

  • Oligo-Asp tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins.

    Akio Ojida;Kei Honda;Daisuke Shinmi;Shigeki Kiyonaka

  • Bis(Dpa-Zn(II)) appended xanthone: excitation ratiometric chemosensor for phosphate anions.

    Akio Ojida;Hiroshi Nonaka;Yoshifumi Miyahara;Shun Ichi Tamaru

  • pH-Responsive shrinkage/swelling of a supramolecular hydrogel composed of two small amphiphilic molecules.

    Shan Lai Zhou;Shinji Matsumoto;Huai Dong Tian;Hiroki Yamane

  • Efficient fluorescent ATP-sensing based on coordination chemistry under aqueous neutral conditions

    Akio Ojida;Sun Kyu Park;Yasuko Mito-Oka;Itaru Hamachi

  • Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

    Tomohiro Kaku;Takenori Hitaka;Akio Ojida;Nobuyuki Matsunaga

  • Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence

    Akiyuki Nishimura;Tsukasa Shimauchi;Tsukasa Shimauchi;Tomohiro Tanaka;Kakeru Shimoda;Kakeru Shimoda

  • Cross-linking strategy for molecular recognition and fluorescent sensing of a multi-phosphorylated peptide in aqueous solution.

    Akio Ojida;Masa Aki Inoue;Yasuko Mito-oka;Itaru Hamachi

  • Design of dual-emission chemosensors for ratiometric detection of ATP derivatives

    Akio Ojida;Yoshifumi Miyahara;Jirarut Wongkongkatep;Shun Ichi Tamaru

Frequent Co-Authors

Itaru Hamachi
Itaru Hamachi Kyoto University
Kazuki Sada
Kazuki Sada Hokkaido University
Nobutaka Fujii
Nobutaka Fujii Kyoto University
Mayumi Ono
Mayumi Ono Kyushu University
Hirokazu Tamamura
Hirokazu Tamamura Tokyo Medical and Dental University
Yasuo Mori
Yasuo Mori Kyoto University
Motohiro Nishida
Motohiro Nishida Kyushu University
Yoshito Kumagai
Yoshito Kumagai University of Tsukuba
Ryuichi Shigemoto
Ryuichi Shigemoto Institute of Science and Technology Austria
Michael B. Zwick
Michael B. Zwick Scripps Research Institute

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