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Takeshi Azuma

Takeshi Azuma

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
24408
World Ranking
3506
National Ranking
216

Overview

Takeshi Azuma is affiliated with Kobe University in Japan and has an extensive body of work primarily situated within the field of Medicine. Their research contributions span several subfields including Oncology, Pulmonary and Respiratory Medicine, Surgery, Molecular Biology, and Ophthalmology.

The scientist's research topics focus mainly on Cancer Immunotherapy and Biomarkers, Bladder and Urothelial Cancer Treatments, Retinal Diseases and Treatments, Immune Cell Function and Interaction, Renal Cell Carcinoma Treatment, Glaucoma and Retinal Disorders, and Epigenetics and DNA Methylation.

Frequent coauthors collaborating with Takeshi Azuma include:

  • Sachi Honda
  • Shohei Iwata
  • Fusako Niimi
  • Takumi Takeuchi
  • Tetsuya Danno

Azuma has published multiple papers across notable journals. Key recent papers include:

  • Serum soluble B7-H3 is a prognostic marker for patients with non-muscle-invasive bladder cancer, 2020, PLoS ONE
  • Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula, 2024, JAMA Ophthalmology (authored primarily by Kyoko Ohno-Matsui)
  • Nivolumab and Ipilimumab Combination Immunotherapy for Patients with Metastatic Collecting Duct Carcinoma, 2021, Case Reports in Urology (authored primarily by Tetsuya Danno)
  • EXTREME MACULAR SCHISIS-SIMULATING RETINAL DETACHMENT IN EYES WITH PATHOLOGIC MYOPIA, 2022, Retina (authored primarily by Kengo Uramoto)
  • Genome-Wide Association Study Adjusted for Occupational and Environmental Factors for Bladder Cancer Susceptibility, 2022, Genes (authored primarily by Takumi Takeuchi)

Azuma's work has appeared frequently in select publication venues, including:

  • Molecular and Clinical Oncology
  • PLoS ONE
  • Retina
  • Cureus
  • Annals of the Rheumatic Diseases

The integration of clinical oncology and ophthalmology illustrates the scientist's multidisciplinary approach, addressing complex diseases such as bladder cancer and retinal disorders. Their focus on immune system function and cancer immunotherapy reflects contemporary directions in medical research.

Best Publications

  • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

    Hideaki Higashi;Ryouhei Tsutsumi;Syuichi Muto;Toshiro Sugiyama

  • Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

    Naomi Ohnishi;Hitomi Yuasa;Shinya Tanaka;Hirofumi Sawa

  • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

    Hideaki Higashi;Ryouhei Tsutsumi;Akiko Fujita;Shiho Yamazaki

  • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

    Yuko Matsumoto;Hiroyuki Marusawa;Kazuo Kinoshita;Yoko Endo

  • Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

    N Murata-Kamiya;Y Kurashima;Y Teishikata;Y Yamahashi

  • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

    Takeshi Azuma;Sheng Yao;Gefeng Zhu;Andrew S. Flies

  • Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

    Iraj Saadat;Hideaki Higashi;Chikashi Obuse;Mayumi Umeda

  • Recombination and clonal groupings within Helicobacter pylori from different geographical regions.

    M Achtman;T Azuma;D E Berg;Y Ito

  • Asia-Pacific consensus guidelines on gastric cancer prevention.

    Kwong Ming Fock;Nick Talley;Paul Moayyedi;Richard Hunt

  • Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan.

    Yoshiyuki Ito;Takeshi Azuma;Shigeji Ito;Hideki Miyaji

  • Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

    Hideaki Higashi;Akihiro Nakaya;Ryouhei Tsutsumi;Kazuyuki Yokoyama

  • Distinctiveness of Genotypes of Helicobacter pylori in Calcutta, India

    Asish K. Mukhopadhyay;Dangeruta Kersulyte;Jin-Yong Jeong;Simanti Datta

  • Human CD4+ CD25+ Regulatory T Cells Suppress NKT Cell Functions

    Takeshi Azuma;Tsuyoshi Takahashi;Atsushi Kunisato;Tadaichi Kitamura

  • A Novel Serum Metabolomics-Based Diagnostic Approach for Colorectal Cancer

    Shin Nishiumi;Takashi Kobayashi;Atsuki Ikeda;Tomoo Yoshie

  • Analysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cells.

    Tsuyoshi Takahashi;Shigeru Chiba;Mie Nieda;Takeshi Azuma

  • Association between Diversity in the Src Homology 2 Domain-Containing Tyrosine Phosphatase Binding Site of Helicobacter pylori CagA Protein and Gastric Atrophy and Cancer

    Takeshi Azuma;Shiho Yamazaki;Akiyo Yamakawa;Masahiro Ohtani

  • Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

    Ryouhei Tsutsumi;Atsushi Takahashi;Takeshi Azuma;Hideaki Higashi

  • Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA

    Masanori Naito;Takeshi Yamazaki;Ryouhei Tsutsumi;Hideaki Higashi

  • Meta-analysis of the relationship between CagA seropositivity and gastric cancer.

    Takeshi Azuma;Masahiro Ohtani;Yukinao Yamazaki;Hideaki Higashi

  • Helicobacter pylori CagA protein can be tyrosine phosphorylated in the gastric epithelial cells

    Takeshi Azuma;Momoyo Asahi;Shigeji Ito;Hiroyuki Suto

Frequent Co-Authors

Tsuyoshi Fujita
Tsuyoshi Fujita University of Tokyo
Masanori Hatakeyama
Masanori Hatakeyama University of Tokyo
Tadaomi Takenawa
Tadaomi Takenawa Kobe University
Yoh Zen
Yoh Zen King's College London
Yoshiyuki Mizushina
Yoshiyuki Mizushina Shinshu University
Masato Kasuga
Masato Kasuga National Center For Global Health and Medicine
Yoshio Yamaoka
Yoshio Yamaoka Oita University
Kenji Yamamoto
Kenji Yamamoto Kyushu University
Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital
Ichizo Kobayashi
Ichizo Kobayashi University of Tokyo

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