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Mark J. Federspiel

Mark J. Federspiel

D-Index & Metrics

Microbiology

D-Index
44
Citations
6633
World Ranking
5164
National Ranking
1978

Overview

Mark J. Federspiel is affiliated with the Mayo Clinic in the United States and conducts research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans various subfields including Genetics, Immunology, Epidemiology, Molecular Biology, and Ophthalmology.

The scientist's research topics focus prominently on virus-based gene therapy, immunotherapy and immune responses, interferon and immune responses, ocular oncology and treatments, virology and viral diseases, respiratory viral infections, and herpesvirus infections and treatments.

Recent publications by Mark J. Federspiel include:

  • Carcinoembryonic antigen-expressing oncolytic measles virus derivative in recurrent glioblastoma: a phase 1 trial (2024), Nature Communications
  • A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses (2023), Frontiers in Immunology
  • Preclinical safety assessment of MV-s-NAP, a novel oncolytic measles virus strain armed with an H. pylori immunostimulatory bacterial transgene (2022), Molecular Therapy - Methods & Clinical Development
  • Oncolytic Urabe mumps virus: A promising virotherapy for triple-negative breast cancer (2022), Molecular Therapy - Oncolytics
  • Live Attenuated Measles Virus Vaccine Expressing Helicobacter pylori Heat Shock Protein A (2020), Molecular Therapy - Oncolytics

Frequent publication venues for Federspiel include:

  • Molecular Therapy - Oncolytics
  • Nature Communications
  • Frontiers in Immunology
  • Molecular Therapy - Methods & Clinical Development
  • Journal of Medicinal Chemistry

Collaboration plays a significant role in their research output, with common coauthors being Evanthia Galanis, Kimberly Viker, Ianko Iankov, Cheyne Kurokawa, and Steven I. Robinson.

Best Publications

  • Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

    Evanthia Galanis;Lynn C. Hartmann;William A. Cliby;Harry J. Long

  • Extended analysis of the in vitro tropism of porcine endogenous retrovirus.

    Carolyn A. Wilson;Susan Wong;Matthew VanBrocklin;Mark J. Federspiel

  • The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors.

    Janet Schaefer-Klein;Iris Givol;Eugene V. Barsov;Jeannette M. Whitcomb

  • Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer.

    Maria P. De Miguel;Linzhao Cheng;Eric C. Holland;Mark J. Federspiel

  • A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors

    Mark J. Federspiel;Paul Bates;John A. T. Young;Harold E. Varmus;Harold E. Varmus

  • Oncolytic Measles Virus Expressing the Sodium Iodide Symporter to Treat Drug-Resistant Ovarian Cancer

    Evanthia Galanis;Pamela J. Atherton;Matthew J. Maurer;Keith L Knutson

  • Infected cell carriers: A new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy

    Ianko D Iankov;Boris Blechacz;Chunsheng Liu;Jeffrey D Schmeckpeper

  • Retroviral gene delivery

    Mark J. Federspiel;Stephen H. Hughes

  • Preclinical Pharmacology and Toxicology of Intravenous MV-NIS, an Oncolytic Measles Virus Administered With or Without Cyclophosphamide

    Myers Rm;Greiner Sm;Harvey Me;Griesmann G

  • Phase I trial of systemic administration of Edmonston strain of measles virus genetically engineered to express the sodium iodide symporter in patients with recurrent or refractory multiple myeloma.

    Angela Dispenzieri;Caili Tong;Betsy LaPlant;Martha Q. Lacy

  • Optimizing patient derived mesenchymal stem cells as virus carriers for a Phase I clinical trial in ovarian cancer

    Emily K. Mader;Greg Butler;Sean C. Dowdy;Andrea Mariani

  • Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma

    Boris Blechacz;Patrick L. Splinter;Suzanne Greiner;Rae Myers

  • Dual Therapy of Ovarian Cancer Using Measles Viruses Expressing Carcinoembryonic Antigen and Sodium Iodide Symporter

    Kosei Hasegawa;Linh Pham;Michael K. O'Connor;Mark J. Federspiel

  • Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects

    Pavlos Msaouel;Mateusz Opyrchal;Angela Dispenzieri;Kah Whye Peng

  • Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer

    Manish R. Patel;Blake A. Jacobson;Yan Ji;Jeremy Drees

  • Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

    Cory Allen;Mateusz Opyrchal;Ileana Aderca;Mark A. Schroeder

  • Expression of IFN-β Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma

    Candice L. Willmon;Vassiliki Saloura;Zvi G. Fridlender;Phonphimon Wongthida

  • Using clinically approved cyclophosphamide regimens to control the humoral immune response to oncolytic viruses

    Peng Kw;Myers R;Greenslade A;Mader E

  • Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth

    Hooi Tin Ong;Mark J. Federspiel;Chang M. Guo;London Lucien Ooi

  • Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas

    Rae Myers;Mary Harvey;Timothy J. Kaufmann;Suzanne M. Greiner

  • Evaluation of an Attenuated Vesicular Stomatitis Virus Vector Expressing Interferon-β for Use in Malignant Pleural Mesothelioma: Heterogeneity in Interferon Responsiveness Defines Potential Efficacy

    Vassiliki Saloura;Liang Chuan S. Wang;Zvi G. Fridlender;Jing Sun

Frequent Co-Authors

Kah Whye Peng
Kah Whye Peng Mayo Clinic
Evanthia Galanis
Evanthia Galanis Mayo Clinic
Glen N. Barber
Glen N. Barber University of Miami
Kent R. Bailey
Kent R. Bailey Mayo Clinic
David Dingli
David Dingli Mayo Clinic
Martha Q. Lacy
Martha Q. Lacy Mayo Clinic
Morie A. Gertz
Morie A. Gertz Mayo Clinic
John C. Morris
John C. Morris Washington University in St. Louis

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