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Microbiology

D-Index
40
Citations
6757
World Ranking
5497
National Ranking
2077

Overview

Jonah B. Sacha is affiliated with Oregon Health & Science University in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a significant number of publications in these areas.

The main subfields of study include Immunology, Epidemiology, Infectious Diseases, Virology, and Molecular Biology. Their research topics cover various aspects of immunology and infection, with emphasis on:

  • HIV Research and Treatment
  • Cytomegalovirus and herpesvirus research
  • Immune Cell Function and Interaction
  • COVID-19 Clinical Research Studies
  • T-cell and B-cell Immunology
  • SARS-CoV-2 and COVID-19 Research
  • Long-Term Effects of COVID-19

Jonah B. Sacha has contributed to multiple scientific publications, with recent notable papers including:

  • CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14 (2020) in International Journal of Infectious Diseases
  • Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19 (2021) in Journal of Leukocyte Biology
  • Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19 (2020) in bioRxiv (Cold Spring Harbor Laboratory)
  • Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab (2021) in Journal of Translational Autoimmunity
  • The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques (2020) in PLoS Pathogens

Their work has been published extensively in several frequent venues such as:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • Nature Communications
  • Science Immunology

Jonah B. Sacha has collaborated frequently with a group of co-authors, including Helen L. Wu, Jason S. Reed, Scott G. Hansen, Gabriela M. Webb, and Michael K. Axthelm. Each of these colleagues has co-authored multiple publications with Sacha.

Best Publications

  • Immune clearance of highly pathogenic SIV infection

    Scott G. Hansen;Michael Piatak;Abigail B. Ventura;Colette M. Hughes

  • Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

    Stephen A. Migueles;Christine M. Osborne;Cassandra Royce;Alex A. Compton

  • Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

    Scott G. Hansen;Jonah B. Sacha;Colette M. Hughes;Julia C. Ford

  • TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

    Glen M. Chew;Tsuyoshi Fujita;Tsuyoshi Fujita;Gabriela M. Webb;Benjamin J. Burwitz;Benjamin J. Burwitz

  • Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.

    Scott G. Hansen;Helen L. Wu;Benjamin J. Burwitz;Colette M. Hughes

  • Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.

    Jonah B. Sacha;Chungwon Chung;Eva G. Rakasz;Sean P. Spencer

  • Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models

    Peter R. Rhode;Jack O. Egan;Wenxin Xu;Hao Hong

  • Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

    Ann J Hessell;Ann J Hessell;J Pablo Jaworski;Erin Epson;Kenta Matsuda

  • CCR5 Inhibition in Critical COVID-19 Patients Decreases Inflammatory Cytokines, Increases CD8 T-Cells, and Decreases SARS-CoV2 RNA in Plasma by Day 14.

    Bruce K. Patterson;Harish Seethamraju;Kush Dhody;Michael J. Corley

  • Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.

    Michael J. Corley;Alina P.S. Pang;Alina P.S. Pang;Kush Dody;Philip A. Mudd

  • Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.

    Jonah B. Sacha;Juan P. Giraldo-Vela;Matthew B. Buechler;Mauricio A. Martins

  • MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

    J M Greene;P Dash;S Roy;C McMurtrey

  • Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells

    Rebecca P. Payne;Henrik Kløverpris;Jonah B. Sacha;Zabrina Brumme

  • Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19

    Bruce Pattterson;Harish Seetthamraju;Kush Dhody;Michael Corley

  • HERV-K–specific T cells eliminate diverse HIV-1/2 and SIV primary isolates

    R. Brad Jones;Keith E. Garrison;Shariq Mujib;Vesna Mihajlovic

  • A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

    Scott G. Hansen;Emily E. Marshall;Daniel Malouli;Abigail B. Ventura

  • Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation

    Mohamed Abdel-Mohsen;Mohamed Abdel-Mohsen;Leonard Chavez;Ravi Tandon;Glen M. Chew

  • The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.

    Gabriela M. Webb;Shengbin Li;Gwantwa Mwakalundwa;Joy M. Folkvord

  • Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

    Benjamin J. Burwitz;Jochen M. Wettengel;Martin A. Mück-Häusl;Marc Ringelhan

  • Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

    L C Walters;K Harlos;S Brackenridge;D Rozbesky

  • The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

    Matthew R. Reynolds;Jonah B. Sacha;Jonah B. Sacha;Andrea M. Weiler;Gretta J. Borchardt

  • Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation

    Jonah B. Sacha;Chungwon Chung;Jason Reed;Anna K. Jonas

Frequent Co-Authors

Michael K. Axthelm
Michael K. Axthelm Oregon National Primate Research Center
Louis J. Picker
Louis J. Picker Oregon Health & Science University
Klaus Früh
Klaus Früh Oregon Health & Science University
Nancy L. Haigwood
Nancy L. Haigwood Oregon Health & Science University
David I. Watkins
David I. Watkins George Washington University
Steven G. Deeks
Steven G. Deeks University of California, San Francisco
Douglas F. Nixon
Douglas F. Nixon Cornell University
Jay A. Nelson
Jay A. Nelson Oregon Health & Science University
Lishomwa C. Ndhlovu
Lishomwa C. Ndhlovu Cornell University
Thomas C. Friedrich
Thomas C. Friedrich University of Wisconsin–Madison

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