2001 - Foundation for Promotion of Cancer Research Prize
Gilbert de Murcia focuses on Poly ADP ribose polymerase, Molecular biology, DNA damage, Base excision repair and DNA repair. His study of Poly glycohydrolase is a part of Poly ADP ribose polymerase. His studies deal with areas such as Complementary DNA, Poly [ADP-Ribose] Polymerase 2, PARG and Cell biology as well as Poly glycohydrolase.
His Molecular biology study incorporates themes from Cell culture, Nitric oxide synthase, Inflammation, Mutant and Programmed cell death. His DNA damage study frequently draws connections to adjacent fields such as DNA ligase. His work deals with themes such as Genome instability and Homologous recombination, which intersect with Base excision repair.
Gilbert de Murcia spends much of his time researching Poly ADP ribose polymerase, Molecular biology, Biochemistry, Polymerase and DNA damage. His Poly ADP ribose polymerase research is multidisciplinary, incorporating elements of Apoptosis, DNA repair and Cell biology. His research on Molecular biology also deals with topics like
In the field of Biochemistry, his study on Chromatin, Complementary DNA and Ribose overlaps with subjects such as DNA polymerase II and DNA clamp. His research in Polymerase intersects with topics in Gene expression, Recombinant DNA and NAD+ kinase. The DNA damage study combines topics in areas such as Cell cycle and Poly Polymerase Inhibitor.
His primary scientific interests are in Poly ADP ribose polymerase, Molecular biology, DNA damage, Cell biology and DNA. His Poly ADP ribose polymerase study deals with the bigger picture of Biochemistry. His Molecular biology research incorporates themes from Apoptosis, Telomerase, DNA repair, Telomere and Transcription.
His Base excision repair study, which is part of a larger body of work in DNA damage, is frequently linked to Ataxia Telangiectasia Mutated Proteins, bridging the gap between disciplines. Gilbert de Murcia has researched Cell biology in several fields, including Poly glycohydrolase, Transfection and NAD+ kinase, Enzyme. His work on Polymerase as part of general DNA research is often related to NPM1, RNA polymerase I and Nucleolus, thus linking different fields of science.
His primary areas of investigation include Cell biology, Poly ADP ribose polymerase, Molecular biology, DNA damage and Homologous recombination. He has included themes like Poly glycohydrolase, DNA repair, Histone, Cathepsin B and NAD+ kinase in his Cell biology study. His research on Poly ADP ribose polymerase often connects related areas such as Ribose.
His work carried out in the field of Molecular biology brings together such families of science as Retinoic acid receptor, Promoter, Chromatin immunoprecipitation and Chromatin. His biological study spans a wide range of topics, including Autophagy, Cell, PARP inhibitor, Transfection and Programmed cell death. The study incorporates disciplines such as Base excision repair, DNA ligase and Mutation in addition to Homologous recombination.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Poly(ADP-ribose): novel functions for an old molecule.
Valérie Schreiber;Françoise Dantzer;Jean-Christophe Ame;Gilbert de Murcia.
Nature Reviews Molecular Cell Biology (2006)
The PARP superfamily.
Jean-Christophe Amé;Catherine Spenlehauer;Gilbert de Murcia.
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
Josiane Ménissier de Murcia;Claude Niedergang;Carlotta Trucco;Michèle Ricoul.
Proceedings of the National Academy of Sciences of the United States of America (1997)
XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage
Murielle Masson;Claude Niedergang;Valérie Schreiber;Sylviane Muller.
Molecular and Cellular Biology (1998)
POLY(ADP-RIBOSE) POLYMERASE : A MOLECULAR NICK-SENSOR
Gilbert de Murcia;Josiane Ménissier de Murcia.
Trends in Biochemical Sciences (1994)
Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis LESSON FROM AN UNCLEAVABLE MUTANT
F. Javier Oliver;Guadalupe de la Rubia;Véronique Rolli;M. Carmen Ruiz-Ruiz.
Journal of Biological Chemistry (1998)
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
Jean-Christophe Amé;Véronique Rolli;Valérie Schreiber;Claude Niedergang.
Journal of Biological Chemistry (1999)
Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1
Valérie Schreiber;Jean-Christophe Amé;Pascal Dollé;Inès Schultz.
Journal of Biological Chemistry (2002)
Resistance to endotoxic shock as a consequence of defective NF‐κB activation in poly (ADP‐ribose) polymerase‐1 deficient mice
F.Javier Oliver;F.Javier Oliver;Josiane Ménissier‐de Murcia;Carmela Nacci;Patrice Decker.
The EMBO Journal (1999)
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
Sydney Shall;Gilbert de Murcia.
Mutation Research-dna Repair (2000)
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