What is she best known for?
The fields of study she is best known for:
Josiane Ménissier-de Murcia spends much of her time researching Poly ADP ribose polymerase, Molecular biology, DNA damage, Base excision repair and Mutant.
Her study in Poly ADP ribose polymerase is interdisciplinary in nature, drawing from both Apoptosis and Nucleotide excision repair.
Josiane Ménissier-de Murcia usually deals with Apoptosis and limits it to topics linked to Gene targeting and NAD+ kinase.
Her Molecular biology study combines topics from a wide range of disciplines, such as Nitric oxide synthase, Inflammation, NF-κB, Lipopolysaccharide and 3T3 cells.
Her Base excision repair study deals with Poly glycohydrolase intersecting with Genome instability, X chromosome, Poly [ADP-Ribose] Polymerase 2, PARG and Complementary DNA.
Her work on Enzyme, Cloning, Eukaryotic cell and Endogeny as part of general Biochemistry study is frequently linked to Structure and function, bridging the gap between disciplines.
Her most cited work include:
- Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells (899 citations)
- XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage (813 citations)
- POLY(ADP-RIBOSE) POLYMERASE : A MOLECULAR NICK-SENSOR (714 citations)
What are the main themes of her work throughout her whole career to date?
Josiane Ménissier-de Murcia mainly investigates Poly ADP ribose polymerase, Molecular biology, Polymerase, DNA damage and Biochemistry.
The various areas that she examines in her Poly ADP ribose polymerase study include Apoptosis, DNA repair and Cell biology.
Her studies in Molecular biology integrate themes in fields like Base excision repair, Mutant, Zinc finger, Proliferating cell nuclear antigen and Programmed cell death.
In her research on the topic of Polymerase, DNA replication is strongly related with DNA polymerase.
Josiane Ménissier-de Murcia interconnects Ataxia Telangiectasia Mutated Proteins and Telomerase in the investigation of issues within DNA damage.
Many of her research projects under Biochemistry are closely connected to DNA polymerase II and DNA clamp with DNA polymerase II and DNA clamp, tying the diverse disciplines of science together.
She most often published in these fields:
- Poly ADP ribose polymerase (72.88%)
- Molecular biology (59.32%)
- Polymerase (37.29%)
What were the highlights of her more recent work (between 2004-2011)?
- Poly ADP ribose polymerase (72.88%)
- Cell biology (28.81%)
- Molecular biology (59.32%)
In recent papers she was focusing on the following fields of study:
Josiane Ménissier-de Murcia mainly focuses on Poly ADP ribose polymerase, Cell biology, Molecular biology, DNA damage and DNA.
Her Poly ADP ribose polymerase research includes themes of In vitro and Programmed cell death.
Her biological study spans a wide range of topics, including Endocrinology and Transfection.
Her Molecular biology study combines topics in areas such as Apoptosis and Secretion.
The DNA damage study which covers DNA repair that intersects with Epigenetics, Prophase and Synapsis.
Her research integrates issues of Ataxia Telangiectasia Mutated Proteins and Protein kinase A in her study of DNA.
Between 2004 and 2011, her most popular works were:
- PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation (501 citations)
- Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis (285 citations)
- PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure (187 citations)
In her most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Poly ADP ribose polymerase, DNA damage, Cell biology, Biochemistry and Programmed cell death.
Her Poly ADP ribose polymerase research incorporates elements of Oxidative stress, Molecular biology, DNA ligase, Cathepsin B and NAD+ kinase.
Her Oxidative stress research is multidisciplinary, relying on both Adipose tissue, Mitochondrion and Energy homeostasis.
Her DNA ligase research includes elements of Chromatin, HMG-box and DNA repair.
She works mostly in the field of NAD+ kinase, limiting it down to concerns involving Sirtuin 1 and, occasionally, Metabolism.
Her work in the fields of Programmed cell death, such as Apoptosis-inducing factor, Caspase and Bcl-2 Homologous Antagonist-Killer Protein, overlaps with other areas such as Bcl-2-associated X protein.
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