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Neuroscience

D-Index
53
Citations
11072
World Ranking
5078
National Ranking
2275

Overview

Leyla deToledo-Morrell is affiliated with Rush University Medical Center in the United States. Their research focuses on biochemistry, genetics, and molecular biology, with a strong emphasis on neurology, physiology, molecular biology, genetics, and immunology. The scientist has contributed notably to the understanding of neuroinflammation, neurodegeneration mechanisms, and neurological disease mechanisms and treatments.

Key topics covered in their research include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Inflammation biomarkers and pathways
  • Neurological Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Bioinformatics and Genomic Networks
  • Prion Diseases and Protein Misfolding
  • Diet and metabolism studies

Their recent publications encompass studies related to Alzheimer's disease, cognitive decline, and neurodegeneration. Notable papers include:

  • Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration (2020), Molecular Neurodegeneration
  • Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer's disease patients (2022), Nature Aging
  • Polygenic effects on the risk of Alzheimer's disease in the Japanese population (2024), Alzheimer s Research & Therapy
  • Correction: Polygenic effects on the risk of Alzheimer's disease in the Japanese population (2024), Alzheimer s Research & Therapy

Leyla deToledo-Morrell frequently collaborates with several co-authors in the field. These co-authors include:

  • John C. Morris
  • Michael W. Weiner
  • Robert C. Green
  • Ronald C. Petersen
  • Laurel Beckett

The scientist publishes primarily in journals focused on neurological and neurodegenerative research, with repeated contributions to:

  • Alzheimer s Research & Therapy
  • Molecular Neurodegeneration
  • Nature Aging

Best Publications

  • Four distinct trajectories of tau deposition identified in Alzheimer’s disease

    Jacob W Vogel;Alexandra L Young;Neil P Oxtoby;Ruben Smith

  • MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease

    B. C. Dickerson;I. Goncharova;I. Goncharova;M. P. Sullivan;M. P. Sullivan;C. Forchetti

  • White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study.

    David Medina;Leyla deToledo-Morrell;Fabio Urresta;John D.E. Gabrieli;John D.E. Gabrieli

  • Hippocampal markers of age-related memory dysfunction: behavioral, electrophysiological and morphological perspectives.

    Yuri Geinisman;Leyla Detoledo-Morrell;Frank Morrell;Richard E. Heller

  • Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults

    B.C. Dickerson;T.R. Stoub;R.C. Shah;R.A. Sperling

  • Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

    Unknown

  • MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD

    Leyla deToledo-Morrell;T.R Stoub;M Bulgakova;R.S Wilson

  • Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities.

    Yuri Geinisman;Leyla deToledo-Morrell;Frank Morrell

  • Age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders.

    Leyla Detoledo-Morrell;Yuri Geinisman;Frank Morrell

  • Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

    Alzheimer's Disease Neuroimaging Initiative

  • Mild cognitive impairment: pathology and mechanisms

    Elliott J. Mufson;Lester Binder;Scott E. Counts;Steven T. DeKosky

  • Structural synaptic correlate of long-term potentiation: formation of axospinous synapses with multiple, completely partitioned transmission zones.

    Yuri Geinisman;Yuri Geinisman;Leyla Detoledo-Morrell;Frank Morrell;Richard E. Heller

  • MRI predictors of risk of incident Alzheimer disease: a longitudinal study.

    T. R. Stoub;M. Bulgakova;S. Leurgans;D. A. Bennett

  • Subregional neuroanatomical change as a biomarker for Alzheimer's disease

    Dominic Holland;James B. Brewer;Donald J. Hagler;Christine Fennema-Notestine

  • Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer’s disease

    Travis R. Stoub;Leyla deToledo-Morrell;Glenn T. Stebbins;Sue Leurgans

  • Gray Matter Atrophy in Patients With Ischemic Stroke With Cognitive Impairment

    Glenn T. Stebbins;David L. Nyenhuis;Changsheng Wang;Jennifer L. Cox

  • The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

    Giovanni B. Frisoni;Clifford R. Jack;Martina Bocchetta;Corinna Bauer

  • Synapse restructuring associated with the maintenance phase of hippocampal long‐term potentiation

    Yuri Geinisman;Leyla Detoledo-Morrell;Frank Morrell;Inna S. Persina

  • Visuoperceptive region atrophy independent of cognitive status in patients with Parkinson’s disease with hallucinations

    Jennifer G. Goldman;Glenn T. Stebbins;Vy Dinh;Bryan Bernard

  • Survey of protocols for the manual segmentation of the hippocampus: Preparatory steps towards a joint EADC-ADNI harmonized protocol

    Marina Boccardi;Rossana Ganzola;Martina Bocchetta;Michela Pievani

  • The Pattern of Neuropsychological Deficits in Vascular Cognitive Impairment-No Dementia (Vascular CIND)

    David L. Nyenhuis;Philip B. Gorelick;Emily J. Geenen;Clifford A. Smith

Frequent Co-Authors

Ronald J. Killiany
Ronald J. Killiany Boston University
Clifford R. Jack
Clifford R. Jack Mayo Clinic
Charles DeCarli
Charles DeCarli University of California, Davis
Jens C. Pruessner
Jens C. Pruessner University of Konstanz
Liana G. Apostolova
Liana G. Apostolova Indiana University
Giovanni B. Frisoni
Giovanni B. Frisoni University of Geneva
Marilyn S. Albert
Marilyn S. Albert Johns Hopkins University School of Medicine
Jerome A. Yesavage
Jerome A. Yesavage Stanford University
David A. Bennett
David A. Bennett Rush University Medical Center
Reisa A. Sperling
Reisa A. Sperling Brigham and Women's Hospital

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