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Immunology

D-Index
71
Citations
27098
World Ranking
2274
National Ranking
1103

Overview

Susan Gilfillan is affiliated with Washington University in St. Louis in the United States. Their research spans the fields of Immunology and Microbiology as well as Medicine, with significant subfield contributions in Immunology, Neurology, Molecular Biology, Surgery, and Physiology. The scientist's work primarily addresses topics such as Neuroinflammation and Neurodegeneration Mechanisms, IL-33, ST2, and ILC Pathways, Immune Cell Function and Interaction, Eosinophilic Esophagitis, Inflammation biomarkers and pathways, Immune cells in cancer, and T-cell and B-cell Immunology.

Their publication record includes papers in prominent scientific venues, reflecting a focus on immunity and neurological disorders. Frequent publication venues include:

  • Proceedings of the National Academy of Sciences
  • The Journal of Immunology
  • Cell
  • Nature Immunology
  • Nature Medicine

Notable recent papers authored or co-authored by Susan Gilfillan include:

  • "Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease" (2020, Nature Medicine)
  • "TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy" (2020, Cell)
  • "Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model" (2020, The Journal of Experimental Medicine)
  • "Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders" (2021, Science)
  • "TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways" (2022, Cell)

Their collaborative network involves frequent co-authorship with researchers such as:

  • Marco Colonna
  • Marina Cella
  • Maxim N. Artyomov
  • José Luís Fachi
  • Tihana Tršan

The scope of the scientist's investigations covers immune mechanisms relevant to neurodegenerative diseases, with a substantial focus on cellular responses mediated by the TREM2 receptor in microglia and interaction with neuroinflammatory pathways. Their research also addresses the role of immune cells in cancer and the interplay among various immune cell populations within tissue microenvironments.

Best Publications

  • TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

    Yaming Wang;Yaming Wang;Marina Cella;Kaitlin Mallinson;Jason D. Ulrich

  • Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

    Leonid Gitlin;Winfried Barchet;Susan Gilfillan;Marina Cella

  • Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

    Emmanuel Treiner;Livine Duban;Seiamak Bahram;Mirjana Radosavljevic

  • TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.

    Tyler K. Ulland;Wilbur M. Song;Stanley Ching Cheng Huang;Jason D. Ulrich

  • IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

    Yaming Wang;Kristy J Szretter;William Vermi;William Vermi;Susan Gilfillan

  • Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

    Yingyue Zhou;Wilbur M. Song;Prabhakar S. Andhey;Amanda Swain

  • Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

    Anja Fuchs;William Vermi;William Vermi;Jacob S. Lee;Silvia Lonardi

  • Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.

    Luisa Cervantes-Barragan;Jiani N. Chai;Ma Diarey Tianero;Blanda Di Luccia

  • TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

    Yaming Wang;Yaming Wang;Tyler K. Ulland;Jason D. Ulrich;Wilbur Song

  • Cutting Edge: TREM-2 Attenuates Macrophage Activation

    Isaiah R. Turnbull;Susan Gilfillan;Marina Cella;Taiki Aoshi

  • Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

    Michelle L Robinette;Anja Fuchs;Victor S Cortez;Jacob S Lee

  • Mice lacking TdT: mature animals with an immature lymphocyte repertoire

    Susan Gilfillan;Andrée Dierich;Marianne Lemeur;Christophe Benoist

  • TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

    Martina Molgora;Ekaterina Esaulova;William Vermi;Jinchao Hou

  • NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

    Susan Gilfillan;Emily L. Ho;Marina Cella;Wayne M. Yokoyama

  • TREM2 sustains microglial expansion during aging and response to demyelination

    Pietro Luigi Poliani;Yaming Wang;Elena Fontana;Michelle L. Robinette

  • The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

    Christopher J Chan;Ludovic Martinet;Susan Gilfillan;Fernando Souza-Fonseca-Guimaraes

  • Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.

    Shoutang Wang;Meer Mustafa;Carla M. Yuede;Santiago Viveros Salazar

  • TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

    Unknown

  • Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.

    Melissa Swiecki;Susan Gilfillan;William Vermi;Yaming Wang

  • Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.

    Simone Brioschi;Wei Le Wang;Vincent Peng;Meng Wang

  • DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.

    Susan Gilfillan;Christopher J. Chan;Marina Cella;Nicole M. Haynes

  • Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.

    Laura Piccio;Cecilia Buonsanti;Margherita Mariani;Marina Cella

Frequent Co-Authors

Marco Colonna
Marco Colonna Washington University in St. Louis
Marina Cella
Marina Cella Washington University in St. Louis
William Vermi
William Vermi University of Brescia
Maxim N. Artyomov
Maxim N. Artyomov Washington University in St. Louis
Rodney D. Newberry
Rodney D. Newberry Washington University in St. Louis
Seiamak Bahram
Seiamak Bahram University of Strasbourg
Christophe Benoist
Christophe Benoist Harvard University
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Diane Mathis
Diane Mathis Harvard University
Robert D. Schreiber
Robert D. Schreiber Washington University in St. Louis

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