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Biology and Biochemistry

D-Index
60
Citations
17443
World Ranking
11758
National Ranking
5057

Overview

Stephen A. Adam is affiliated with Northwestern University in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Cell Biology, and Genetics. Their work also intersects with Biomaterials and Neurology on a smaller scale.

The scientist's research topics cover a range of areas including:

  • Nuclear Structure and Function
  • RNA Research and Splicing
  • Cellular Mechanics and Interactions
  • Skin and Cellular Biology Research
  • Genomics and Chromatin Dynamics
  • Virus-based gene therapy research
  • Biotin and Related Studies

Recent notable publications by Stephen A. Adam include:

  • Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics, 2022, Proceedings of the National Academy of Sciences
  • Nuclear lamins: Structure and function in mechanobiology, 2022, APL Bioengineering
  • Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex, 2022, Proceedings of the National Academy of Sciences
  • Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins, 2021, The Journal of Cell Biology
  • Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells, 2022, Frontiers in Cell and Developmental Biology

Stephen A. Adam frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • The Journal of Cell Biology
  • APL Bioengineering
  • Frontiers in Cell and Developmental Biology

Co-authorships with other researchers are a significant part of their scientific collaboration, often working with:

  • Robert D. Goldman
  • Ohad Medalia
  • Joseph R. Tran
  • Yixian Zheng
  • Suganya Sivagurunathan

Their research contributes to understanding critical molecular and cellular mechanisms, especially concerning nuclear structure, cytoskeletal dynamics, and gene expression regulation within cellular contexts.

Best Publications

  • Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

    Stephen A. Adam;Rachel Sterne Marr;Larry Gerace

  • Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

    Dale K. Shumaker;Thomas Dechat;Alexander Kohlmaier;Alexander Kohlmaier;Stephen A. Adam

  • Importin α: A multipurpose nuclear-transport receptor

    David S. Goldfarb;Anita H. Corbett;D. Adam Mason;Michelle T. Harreman

  • Autophagy mediates degradation of nuclear lamina

    Zhixun Dou;Caiyue Xu;Greg Donahue;Takeshi Shimi

  • mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.

    S A Adam;T Nakagawa;M S Swanson;T K Woodruff

  • The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

    Takeshi Shimi;Katrin Pfleghaar;Katrin Pfleghaar;Shin Ichiro Kojima;Chan Gi Pack

  • Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import.

    Stephen A. Adam;Stephen A. Adam;Larry Geracet

  • The role of nuclear lamin B1 in cell proliferation and senescence

    Takeshi Shimi;Veronika Butin-Israeli;Stephen A. Adam;Robert B. Hamanaka

  • Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription.

    G Dreyfuss;S A Adam;Y D Choi

  • Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope

    Ermoné J.H. Adam;Stephen A Adam

  • Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly

    Christiane Wiese;Andrew Wilde;Mary Shannon Moore;Stephen A. Adam

  • Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

    Andrew D. Stephens;Edward J. Banigan;Stephen A. Adam;Robert D. Goldman

  • Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler

    Yu Chen;Yang Zhang;Yang Zhang;Yuchuan Wang;Liguo Zhang

  • Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms DIRECT AND INDIRECT EFFECTS ON NUCLEAR/CYTOPLASMIC SHUTTLING AND DNA BINDING

    Xiaohui Zhang;Lixia Gan;Haiyun Pan;Shaodong Guo

  • Sequence and characterization of cytoplasmic nuclear protein import factor p97.

    Neil C. Chi;Ermoné J.H. Adam;Stephen A. Adam

  • A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly

    Ming Ying Tsai;Shusheng Wang;Jill M. Heidinger;Jill M. Heidinger;Jill M. Heidinger;Dale K. Shumaker;Dale K. Shumaker;Dale K. Shumaker

  • Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging

    Thomas Dechat;Takeshi Shimi;Stephen A. Adam;Antonio E. Rusinol

  • Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

    Andrew D. Stephens;Patrick Z. Liu;Edward J. Banigan;Edward J. Banigan;Luay M. Almassalha

  • Nuclear lamin functions and disease.

    Veronika Butin-Israeli;Stephen A. Adam;Anne E. Goldman;Robert D. Goldman

  • The nuclear pore complex.

    Stephen A Adam

Frequent Co-Authors

Robert D. Goldman
Robert D. Goldman Northwestern University
Yixian Zheng
Yixian Zheng Carnegie Institution for Science
John F. Marko
John F. Marko Northwestern University
Gideon Dreyfuss
Gideon Dreyfuss University of Pennsylvania
Neil C. Chi
Neil C. Chi University of California, San Diego
Larry Gerace
Larry Gerace Scripps Research Institute
Vladimir I. Gelfand
Vladimir I. Gelfand Northwestern University
John R. Yates
John R. Yates Scripps Research Institute
Andrew S. Belmont
Andrew S. Belmont University of Illinois at Urbana-Champaign
Bas van Steensel
Bas van Steensel Antoni van Leeuwenhoek Hospital

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