World's Best Scientists 2026 revealed!
Karsten Weis

Karsten Weis

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
16627
World Ranking
10089
National Ranking
178

Research.com Recognitions

  • 2002 - Hellman Fellow

Overview

Karsten Weis is affiliated with ETH Zurich in Switzerland and focuses on research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans molecular biology, cell biology, immunology, biochemistry, and epidemiology, with a particular emphasis on RNA research and splicing, RNA modifications and cancer, mechanisms of RNA and protein synthesis, nuclear structure and function, cancer-related gene regulation, lipid metabolism and biosynthesis, and autophagy in disease and therapy.

Their recent publications reflect a broad engagement with cellular and molecular mechanisms. Notable papers include:

  • "The cellular environment shapes the nuclear pore complex architecture," 2021, published in Nature
  • "Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity," 2022, published in Nature Communications
  • "Membraneless organelles: phasing out of equilibrium," 2020, published in Emerging Topics in Life Sciences
  • "Maturation Kinetics of a Multiprotein Complex Revealed by Metabolic Labeling," 2020, published in Cell
  • "The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates," 2022, published in Annual Review of Biochemistry

Within their collaborative network, frequent co-authors include Jonas S. Fischer, Sarah Khawaja, Maria Hondele, Matthias Wojtynek, and Stephanie Heinrich. This reflects an ongoing cooperation with researchers from related fields and complementary areas of study.

Karsten Weis has contributed extensively to scientific literature, with a large number of publications appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Blood, Nature Communications, Cell Reports, and Nature. These venues highlight the interdisciplinary nature and international scope of their research outputs.

The researcher's primary fields and topics studied are:

  • Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Cell Biology
  • Immunology
  • Biochemistry
  • Epidemiology

Major topics addressed in their research include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Nuclear Structure and Function
  • Cancer-related gene regulation
  • Lipid metabolism and biosynthesis
  • Autophagy in Disease and Therapy

Karsten Weis was awarded the Hellman Fellow in 2002, an early career recognition. The award attests to their standing within the scientific community during their career.

Best Publications

  • Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

    Katrin Stade;Charleen S. Ford;Christine Guthrie;Karsten Weis

  • Regulating Access to the Genome: Nucleocytoplasmic Transport throughout the Cell Cycle

    Karsten Weis

  • Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

    Karsten Weis;Sophie Rambaud;Catherine Lavau;Joop Jansen

  • Structure of importin-beta bound to the IBB domain of importin-alpha.

    Gino Cingolani;Carlo Petosa;Karsten Weis;Christoph W. Müller

  • Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg Extracts

    Petr Kalab;Karsten Weis;Rebecca Heald

  • Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

    Maxence V Nachury;Thomas J Maresca;Wendy C Salmon;Clare M Waterman-Storer

  • Identification of hSRP1α as a Functional Receptor for Nuclear Localization Sequences

    Karsten Weis;Iain W. Mattaj;Angus I. Lamond

  • Analysis of a RanGTP-regulated gradient in mitotic somatic cells

    Petr Kaláb;Arnd Pralle;Ehud Y. Isacoff;Rebecca Heald

  • DEAD-box ATPases are global regulators of phase-separated organelles

    Maria Hondele;Ruchika Sachdev;Stephanie Heinrich;Juan Wang

  • Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.

    Christine S. Weirich;Jan P. Erzberger;Jeffrey S. Flick;Jeffrey S. Flick;James M. Berger

  • Importins and exportins: how to get in and out of the nucleus

    Karsten Weis

  • Importin-beta-like nuclear transport receptors

    Anne-Christine Ström;Karsten Weis

  • The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

    Karsten Weis;Ursula Ryder;Angus I. Lamond

  • A Rae1-Containing Ribonucleoprotein Complex Is Required for Mitotic Spindle Assembly

    Michael D. Blower;Maxence Nachury;Rebecca Heald;Karsten Weis

  • Characterization of HIV-1 Vpr Nuclear Import: Analysis of Signals and Pathways

    Yonchu Jenkins;Michele McEntee;Karsten Weis;Warner C. Greene

  • Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

    Jonathan F. Soderholm;Stephen L. Bird;Petr Kalab;Petr Kalab;Yasaswini Sampathkumar

  • A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.

    Ben Montpetit;Nathan D. Thomsen;Nathan D. Thomsen;Kara J. Helmke;Markus A. Seeliger;Markus A. Seeliger

  • The direction of transport through the nuclear pore can be inverted

    Maxence V. Nachury;Karsten Weis

  • Selectivity Mechanism of the Nuclear Pore Complex Characterized by Single Cargo Tracking

    Alan R. Lowe;Jake J. Siegel;Petr Kalab;Merek Siu

  • Nucleocytoplasmic transport: cargo trafficking across the border.

    Karsten Weis

Frequent Co-Authors

Rebecca Heald
Rebecca Heald University of California, Berkeley
Paolo Arosio
Paolo Arosio ETH Zurich
Angus I. Lamond
Angus I. Lamond University of Dundee
James M. Berger
James M. Berger Johns Hopkins University
Maxence V. Nachury
Maxence V. Nachury University of California, San Francisco
Jay T. Groves
Jay T. Groves University of California, Berkeley
W. E. Moerner
W. E. Moerner Stanford University
David Grunwald
David Grunwald University of Utah
Uwe Sauer
Uwe Sauer ETH Zurich
Iain W. Mattaj
Iain W. Mattaj Human Technopole

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