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Biology and Biochemistry

D-Index
51
Citations
7523
World Ranking
17349
National Ranking
326

Overview

Nicolas Fasel is affiliated with the University of Lausanne in Switzerland. Their research is situated primarily at the intersection of medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Fasel's scholarly contributions span multiple specialized subfields, including public health, environmental and occupational health, immunology, molecular biology, infectious diseases, and epidemiology.

Their work encompasses several major topics of investigation:

  • Research on Leishmaniasis Studies
  • Viral Infections and Vectors
  • Inflammasome and immune disorders
  • Interferon and immune responses
  • Trypanosoma species research and implications
  • Cell death mechanisms and regulation
  • PARP inhibition in cancer therapy

Nicolas Fasel has published extensively and contributed to a range of scientific venues, with a notable presence in the following publication outlets:

  • Frontiers in Cellular and Infection Microbiology (4 publications)
  • Molecular Cell
  • Virology Journal
  • PLoS Pathogens
  • Pathogens

Representative recent papers include:

  • Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases, 2020, Molecular Cell
  • Viruses of protozoan parasites and viral therapy: Is the time now right?, 2020, Virology Journal
  • The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism, 2021, PLoS Pathogens
  • The Dangerous Liaisons in the Oxidative Stress Response to Leishmania Infection, 2022, Pathogens
  • Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism, 2020, Frontiers in Cellular and Infection Microbiology

Frequent collaborators in Fasel's research include:

  • Tiia Snäkä
  • Chantal Desponds
  • Florence Prével
  • Marta Reverte
  • Nathalie Isorce

The scope of Fasel's work reflects a focus on host-pathogen interactions, immune response regulation, and the molecular biology of infectious diseases, especially those caused by parasitic protozoans such as Leishmania and Trypanosoma species. Their research contributions provide insight into inflammation processes, oxidative stress responses, and immune system modulation within these disease contexts.

Best Publications

  • Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.

    Annette Ives;Catherine Ronet;Florence Prevel;Giulia Ruzzante

  • The proteolytic activity of the paracaspase MALT1 is key in T cell activation.

    Fabien Rebeaud;Stephan Hailfinger;Anita Posevitz-Fejfar;Myriam Tapernoux

  • Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration

    Caroline A. Johnson-Léger;Michel Aurrand-Lions;Nicola Beltraminelli;Nicolas Fasel

  • Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?

    H Zangger;J C Mottram;N Fasel

  • Guidelines and recommendations on yeast cell death nomenclature

    Didac Carmona-Gutierrez;Maria Anna Bauer;Andreas Zimmermann;Andrés Aguilera

  • How to master the host immune system? Leishmania parasites have the solutions!

    Matteo Rossi;Nicolas Fasel

  • Leishmania RNA virus: when the host pays the toll

    Mary-Anne Hartley;Catherine Ronet;Haroun Zangger;Stephen M. Beverley

  • The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription.

    N Fasel;K Pearson;E Buetti;H Diggelmann

  • Apoptotic markers in protozoan parasites.

    Antonio Jiménez-Ruiz;Juan Fernando Alzate;Ewan Thomas MacLeod;Carsten Günter Kurt Lüder

  • DNA methylation predicts age and provides insight into exceptional longevity of bats.

    Gerald S. Wilkinson;Danielle M. Adams;Amin Haghani;Ake T. Lu

  • Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program

    Mikhail Y. Vyssokikh;Susanne Holtze;Olga A. Averina;Konstantin G. Lyamzaev

  • A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major.

    Sima Rafati;Ali-Hatef Salmanian;Tahere Taheri;Manije Vafa

  • Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity

    Iveth J. González;Chantal Desponds;Cédric Schaff;Jeremy C. Mottram

  • Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse

    Eliane Bourreau;Marine Ginouves;Ghislaine Prévot;Mary-Anne Hartley

  • An essential role for the Leishmania major metacaspase in cell cycle progression.

    A Ambit;N Fasel;G H Coombs;J C Mottram

  • Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

    Despina Smirlis;Michael Duszenko;Antonio Jiménez Ruiz;Effie Scoulica

  • Detection of Leishmania RNA Virus in Leishmania Parasites

    Haroun Zangger;Catherine Ronet;Chantal Desponds;F. Matthew Kuhlmann

  • Induction of macrophage nitric oxide production by interferon-γ and tumor necrosis factor-α is enhanced by interleukin-10

    Sally Betz Corradin;Nicolas Fasel;Yolande Buchmüller-Rouiller;Adriana Ransijn

  • Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response.

    Haroun Zangger;Asrat Hailu;Chantal Desponds;Lon-Fye Lye

  • Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis

    Javier Moreno;Javier Nieto;S. Masina;Carmen Cañavate

Frequent Co-Authors

Stephen M. Beverley
Stephen M. Beverley Washington University in St. Louis
Giampietro Corradin
Giampietro Corradin University of Lausanne
Nicole Déglon
Nicole Déglon University of Lausanne
Sima Rafati
Sima Rafati Pasteur Institute of Iran
Jeremy C. Mottram
Jeremy C. Mottram University of York
Fabienne Tacchini-Cottier
Fabienne Tacchini-Cottier University of Lausanne
Peter J. Myler
Peter J. Myler Seattle Children's Hospital
Aubry Tardivel
Aubry Tardivel University of Lausanne
Margot Thome
Margot Thome University of Lausanne
Kenneth Stuart
Kenneth Stuart University of Washington

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