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Immunology

D-Index
45
Citations
6313
World Ranking
4725
National Ranking
4

Overview

Sima Rafati is affiliated with the Pasteur Institute of Iran. Their research career centers predominantly on infectious diseases, with a strong emphasis on parasitology and immunology related to Leishmaniasis and Trypanosoma species. The work contributes significantly to the fields of Medicine, Immunology and Microbiology, with published studies spanning related subfields such as Public Health, Environmental and Occupational Health, Epidemiology, Molecular Biology, Immunology, and Parasitology.

Their scientific topics encompass a range of specialized areas including:

  • Research on Leishmaniasis Studies
  • Trypanosoma species research and implications
  • Toxin Mechanisms and Immunotoxins
  • Parasites and Host Interactions
  • Insect and Pesticide Research
  • RNA Interference and Gene Delivery
  • Extracellular vesicles in disease

Sima Rafati's recent publications reflect ongoing contributions to parasite biology and host-pathogen interactions. Representative papers include:

  • Guidelines for the purification and characterization of extracellular vesicles of parasites, 2023, Journal of Extracellular Biology
  • Lactococcus lactis expressing sand fly PpSP15 salivary protein confers long-term protection against Leishmania major in BALB/c mice, 2020, PLoS neglected tropical diseases
  • Th1 concomitant immune response mediated by IFN-γ protects against sand fly delivered Leishmania infection: Implications for vaccine design, 2020, Cytokine
  • Cytokine saga in visceral leishmaniasis, 2020, Cytokine
  • Molecular signatures of anthroponotic cutaneous leishmaniasis in the lesions of patients infected with Leishmania tropica, 2020, Scientific Reports

The scientist has collaborated frequently with several researchers, including:

  • Negar Seyed
  • Tahereh Taheri
  • Sima Habibzadeh
  • Yasaman Taslimi
  • Elham Gholami

The publication outlets where Sima Rafati's work appears regularly include:

  • PLoS neglected tropical diseases
  • Cytokine
  • Expert Review of Proteomics
  • Frontiers in Immunology
  • PubMed

These affiliations and publication records reflect an established engagement with both experimental and applied aspects of infectious disease research, particularly through immunological and molecular approaches targeting parasites and their vectors.

Best Publications

  • Improvement of different vaccine delivery systems for cancer therapy.

    Azam Bolhassani;Shima Safaiyan;Sima Rafati

  • Leishmaniasis vaccine candidates for development: a global overview.

    Ali Khamesipour;Sima Rafati;Noushin Davoudi;Fereidoun Maboudi

  • Immunological and Genetic Evidence for a Crucial Role of IL-10 in Cutaneous Lesions in Humans Infected with Leishmania braziliensis

    Adnene Salhi;Virmondes Rodrigues;Ferrucio Santoro;Helia Dessein

  • Heat-shock proteins as powerful weapons in vaccine development.

    Azam Bolhassani;Sima Rafati

  • PROTECTIVE VACCINATION AGAINST EXPERIMENTAL CANINE VISCERAL LEISHMANIASIS USING A COMBINATION OF DNA AND PROTEIN IMMUNIZATION WITH CYSTEINE PROTEINASES TYPE I AND II OF L. INFANTUM

    Sima Rafati;Alireza Nakhaee;Tahere Taheri;Yasaman Taslimi

  • A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major.

    Sima Rafati;Ali-Hatef Salmanian;Tahere Taheri;Manije Vafa

  • Recombinant Leishmania tarentolae expressing the A2 virulence gene as a novel candidate vaccine against visceral leishmaniasis.

    Amir Mizbani;Tahereh Taheri;Farnaz Zahedifard;Yasaman Taslimi

  • Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis.

    Sima Rafati;Farnaz Zahedifard;Fereshteh Nazgouee

  • CD8 + T cells in Leishmania infections: friends or foes?

    Simona Stäger;Sima Rafati

  • Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice

    Majid Golkar;Mohammad-Ali Shokrgozar;Sima Rafati;Karine Musset

  • Fluorescent Leishmania species: Development of stable GFP expression and its application for in vitro and in vivo studies

    Azam Bolhassani;Tahereh Taheri;Yasaman Taslimi;Soheila Zamanilui;Soheila Zamanilui

  • Enhanced immunogenicity of HPV16E7 accompanied by Gp96 as an adjuvant in two vaccination strategies.

    Azam Bolhassani;Farnaz Zahedifard;Mohammad Taghikhani;Sima Rafati

  • Immunogenic properties of chimeric protein from espA, eae and tir genes of Escherichia coli O157:H7.

    Jafar Amani;Ali Hatef Salmanian;Sima Rafati;Seyed Latif Mousavi

  • Leishmaniasis and various immunotherapeutic approaches

    Y. Taslimi;F. Zahedifard;S. Rafati

  • Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection

    Delaram Doroud;Farnaz Zahedifard;Alireza Vatanara;Abdolhossein Rouholamini Najafabadi

  • Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis

    Azita Zadeh-Vakili;Tahere Taheri;Yasaman Taslimi;Fatemeh Doustdari

  • Enhanced protective efficacy of nonpathogenic recombinant leishmania tarentolae expressing cysteine proteinases combined with a sand fly salivary antigen.

    Farnaz Zahedifard;Elham Gholami;Tahereh Taheri;Yasaman Taslimi

  • Immunogenicity of a plant-derived edible chimeric EspA, Intimin and Tir of Escherichia coli O157:H7 in mice.

    Jafar Amani;Seyed Latif Mousavi;Sima Rafati;Ali Hatef Salmanian

  • Identification of Leishmania major cysteine proteinases as targets of the immune response in humans.

    Sima Rafati;Ali-Hatef Salmanian;Katayon Hashemi;Cedric Schaff

  • Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.

    Sima Rafati;Elham Gholami;Nafiseh Hassani;Fatemeh Ghaemimanesh

  • Development of Novel Prime-Boost Strategies Based on a Tri-Gene Fusion Recombinant L. tarentolae Vaccine against Experimental Murine Visceral Leishmaniasis

    Noushin Saljoughian;Tahereh Taheri;Farnaz Zahedifard;Yasaman Taslimi

Frequent Co-Authors

Barbara Papadopoulou
Barbara Papadopoulou Université Laval
Nicolas Fasel
Nicolas Fasel University of Lausanne
Alain Dessein
Alain Dessein Aix-Marseille University
Shaden Kamhawi
Shaden Kamhawi National Institutes of Health
Jesus G. Valenzuela
Jesus G. Valenzuela National Institutes of Health
Seyed Moayed Alavian
Seyed Moayed Alavian Baqiyatallah University of Medical Sciences
Mehdi Mohebali
Mehdi Mohebali Tehran University of Medical Sciences
Marie-France Cesbron-Delauw
Marie-France Cesbron-Delauw Grenoble Alpes University
Mohammad Ali Shokrgozar
Mohammad Ali Shokrgozar Pasteur Institute of Iran
Kenji Shibuya
Kenji Shibuya King's College London

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